Abstract
Both leptin and ghrelin used separately at the concentrations corresponding to trimesters II–III of pregnancy increase the number of CD56bright NK cells in mononuclear cell suspension; their combination also enhances the L-selectin expression on the surface of these cells in the culture. These hormones do not affect the production of TGF-β1, IL-17А, or IFN-γ by NK cells, and they inhibit the production of IL-10. Leptin decreses the IL-4 production by NKp46+ cells, but the presence of ghrelin abrogates this effect.
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Original Russian Text © S.V. Shirshev, I.V. Nekrasova, E.G. Orlova, O.L. Gorbunova, 2016, published in Doklady Akademii Nauk, 2016, Vol. 470, No. 5, pp. 603–606.
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Shirshev, S.V., Nekrasova, I.V., Orlova, E.G. et al. Roles of leptin and ghrelin in the regulation of the phenotype and cytokine production by NK cells from peripheral blood. Dokl Biol Sci 470, 249–252 (2016). https://doi.org/10.1134/S0012496616050136
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DOI: https://doi.org/10.1134/S0012496616050136