Abstract
The effect of kisspeptin at concentrations typical of pregnancy on the functional activity of isolated cytokine-primed NK cells has been investigated. The hormone has been shown to promote an increase in the proportion of CD56bright NK cells, as well as an increase in the L-selectin expression on the cell surface. Assessment of cytokine levels has shown that kisspeptin suppresses the production of IL-4, IL-10, and IFN-γ while stimulating the production of TGF-β by isolated NK cells. The overall effect of the hormone investigated consisted in the formation of a phenotype and a cytokine spectrum characteristic of the regulatory NK3 subpopulation of NK cells in pregnancy.
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Original Russian Text © S.V. Shirshev, I.V. Nekrasova, O.L. Gorbunova, E.G. Orlova, I.L. Maslennikova, 2015, published in Doklady Akademii Nauk, 2015, Vol. 464, No. 5, pp. 633–635.
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Shirshev, S.V., Nekrasova, I.V., Gorbunova, O.L. et al. The effect of kisspeptin on the functional characteristics of isolated NK cells. Dokl Biol Sci 464, 267–269 (2015). https://doi.org/10.1134/S0012496615050129
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DOI: https://doi.org/10.1134/S0012496615050129