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Biopolymers for microneedle synthesis: from then to now

  • Original Article
  • Published:
Biomanufacturing Reviews

Abstract

Biopolymeric microneedles have emerged as an efficient tool for transdermal drug delivery system. Being operational alternative to hypodermic needles and non-biopolymeric microneedles, they offer plethora of advantages and ease in drug administration over conventional tools. Needles/microneedles used in medical practise can be disposable devices but may not necessarily be biodegradable, whereas biopolymeric microneedles completely serves for the green technology approach at medical/pharmaceutical outlet. Over a decade, investigation has been engrossed on leveraging biopolymers for microneedle synthesis, however, it seems to be growing more towards synthetic biopolymers than those of non-synthetic/natural biopolymers, may be due to their inherent physico-chemical properties. Nonetheless the outcomes bestowed from the investigations on natural biopolymeric microneedles are surely pertinent to the future practical applications. Henceforth, with the purpose of having insight, illuminating their potential and encouraging their utilisation for developing drug delivery devices, this review summarizes them from then to now with their implicational advancement and clinical potential.

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Fig. 1

Adapted by permission from [43, 72]. Copyright 2005, 2007 Springer Nature

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Adapted by permission from [57]. Copyright 2009 Elsevier

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Adapted by permission from [109]. Copyright 2018 Elsevier

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Adapted by permission from [4, 26]. Copyright 2015, 2016 Elsevier

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Adapted by permission from [23]. Copyright 2009 Taylor & Francis

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Adapted by permission from [56, 80]. Copyright 2008 Elsevier and 2016 Springer Nature

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Adapted by permission from [87]. Copyright 2010 John Wiley and Sons

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Adapted by permission from [47]. Copyright 2015 Springer Nature

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Adapted by permission from [38]. Copyright 2015 RSC Publishing

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Adapted by permission from [58]. Copyright 2013 Acta Materialia Inc. Published by Elsevier

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Adapted by permission from [33]. Copyright 2012 Elsevier

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References

  1. Akers MJ (2002) Excipient-drug interactions in parenteral formulations. J Pharm Sci 91(11):2283–2300

    Article  Google Scholar 

  2. Alarcón-Payán DA, Koyani RD, Vazquez-Duhalt R (2017) Chitosan-based biocatalytic nanoparticles for pollutant removal from waste water. Enzyme Microb Technol 100:71–78

    Article  Google Scholar 

  3. Apollo NV, Jiang J, Cheung W, Baquier S, Lai A, Mirebedini A, Foroughi J, Wallace GG, Shivdasani MN, Prawer S, Chen S, Williams R, Cook MJ, Nayagam DAX, Garrett DJ (2018) Development and characterization of a sucrose microneedle neural electrode delivery system. Adv Biosys 2:1700187

    Article  Google Scholar 

  4. Arya JM, Dewitt K, Scott-Garrard M, Chiang YW, Prausnitz MR (2016) Rabies vaccination in dogs using a dissolving microneedle patch. J Control Release 239:19–26

    Article  Google Scholar 

  5. Bachy V, Hervouet C, Becker PD, Chorro L, Carlin LM, Herath S et al (2013) Langerin negative dendritic cells promote potent CD8+ T cell priming by skin delivery of live adenovirus vaccine microneedle arrays. Proc Nat Acad Sci USA 110(8):3041–3046

    Article  Google Scholar 

  6. Bariya SH, Gohel MC, Mehta TA, Sharma OP (2012) Microneedles: an emerging transdermal drug delivery system. J Pharm Pharmacol 64:11–29

    Article  Google Scholar 

  7. Brogden NK, Milewski M, Ghosh P, Hardi L, Crofford LJ, Stinchcomb AL (2012) Diclofenac delays micropore closure following microneedle treatment in human subjects. J Control Release 163:220–229

    Article  Google Scholar 

  8. Camović M, Biščević A, Brčić I, Borčak K, Bušatlić S, Ćenanović N, Dedović A, Mulalić A, Osmanlić M, Sirbubalo M, Tucak A, Vranić E (2020) Coated 3D printed PLA microneedles as transdermal drug delivery systems. In: Badnjevic A, Škrbić R, Gurbeta Pokvić L (eds) CMBEBIH 2019. CMBEBIH 2019. IFMBE Proceedings, vol 73, pp 735–742, Springer

  9. Chen MC, Lai KY, Ling MH, Lin CW (2018) Enhancing immunogenicity of antigens through sustained intradermal delivery using chitosan microneedles with a patch-dissolvable design. Acta Biomater 65:66–75

    Article  Google Scholar 

  10. Chen BZ, Ashfaq M, Zhang XP, Zhang JN, Guo XN (2018) Invitro and invivo assessment of polymer microneedles for controlled transdermal drug delivery. J Drug Target 26(8):720–729

    Article  Google Scholar 

  11. Chen Y, Chen BZ, Wang QL, Jin X, Guo XD (2017) Fabrication of coated polymer microneedles for transdermal drug delivery. J Control Release 265:14–21

    Article  Google Scholar 

  12. Chen MC, Huang SF, Lai KY, Ling MH (2013) Fully embeddable chitosan microneedles as a sustained release depot for intradermal vaccination. Biomaterials 34:3077–3086

    Article  Google Scholar 

  13. Chen MC, Ling MH, Lai KY, Pramudityo E (2012) Chitosan microneedle patches for sustained transdermal delivery of macromolecules. Biomacromolecules 13(12):4022–4031

    Article  Google Scholar 

  14. Choi HJ, Yoo DG, Bondy BJ, Quan FS, Compans RW, Kang SM, Prausnitz MR (2012) Stability of influenza vaccine coated onto microneedles. Biomaterials 33:3756–3769

    Article  Google Scholar 

  15. Choi SY, Kwon HJ, Ahn GR, Ko EJ, Yoo KH, Kim BJ, Lee C, Kim D (2017) Hyaluronic acid microneedle patch for the improvement of crow's feet wrinkles. Dermatol Ther 30:e12546

    Article  Google Scholar 

  16. Chiu YH, Chen MC, Wan SW (2018) Sodium Hyaluronate/chitosan composite microneedles as a single-dose intradermal immunization system. Biomacromolecules 19(6):2278–2285

    Article  Google Scholar 

  17. Choi JT, Park S, Park JH (2018) Microneedles containing cross-linked hyaluronic acid particulates for control of degradation and swelling behaviour after administration into skin. J Drug Target 26:884–894

    Article  Google Scholar 

  18. Chu LY, Prausnitz MR (2011) Separable arrowhead microneedles. J Control Release 149(3):242–249

    Article  Google Scholar 

  19. Coppola S (2016) Doctoral Thesis, ISASI CNR—Institute of Applied Sciences and Intelligent Systems of Naples, in Manipulation of multiphase materials for touch-less nanobiotechnology: a pyrofluidic platform, Pozzuoli, Italy, Springer Switzerland, Ch. 6, pp 85–97

  20. Demir YK, Akan Z, Kerimoglu O (2013) Characterization of polymeric microneedle arrays for transdermal drug delivery. PLoS One 8(10):e77289

    Article  Google Scholar 

  21. Demir YK, Akan Z, Kerimoglu O (2013) Sodium alginate microneedle arrays mediate the transdermal delivery of bovine serum albumin. PLoS One 8(5):e63819

    Article  Google Scholar 

  22. Donnelly RF, Douroumis D (2015) Microneedles for drug and vaccine delivery and patient monitoring. Drug Deliv Trans Res 5:311–312

    Article  Google Scholar 

  23. Donnelley RF, Morrowm DI, Singh TR, Migalska K, McCarron PA, O’Mahony C, Woolfson AD (2009) Processing difficulties and instability of carbohydrate microneedle arrays. Drug Dev Ind Pharm 35:1242–1254

    Article  Google Scholar 

  24. Donnelly RF, Singh TRR, Woolfson AD (2010) Microneedle-based drug delivery systems: microfabrication, drug delivery, and safety. Drug Deliv 17:187–207

    Article  Google Scholar 

  25. Duverger E, Carpentier V, Roche AC, Monsigny M (1993) Sugar-dependent nuclear import of glycoconjugates from the cytosol. Exp Cell Res 207:197–201

    Article  Google Scholar 

  26. Edens C, Collins ML, Goodson JL, Rota PA, Prausnitz MR (2015) A microneedle patch containing measles vaccine is immunogenic in non-human primates. Vaccine 33(37):4712–4718

    Article  Google Scholar 

  27. Edens C, Dybdahl-Sissoko NC, Weldon WC, Oberste MS, Prausnitz MR (2015) Inactivated polio vaccination using a microneedle patch is immunogenic in the rhesus macaque. Vaccine 33(37):4683–4690

    Article  Google Scholar 

  28. Gaines AR, Pierce LR, Bernhardt PA (2008) Fatal iatrogenic hypoglycemia: falsely elevated blood glucose readings with a point-of-care meter due to a maltose-containing intravenous immune globulin product, 2008-US Food and Drug Adminstration, 2015

  29. Gerstel MS, Place VA (1976) US Patent No. 3,964,482. Washington, DC: US Patent and Trademark Office

  30. Gill HS, Prausnitz MR (2007) Coated microneedles for transdermal delivery. J Control Release 117(2):227–237

    Article  Google Scholar 

  31. González-Vázquez P, Larrañeta E, McCrudden MTC, Jarrahian C, Rein-Weston A, Quintanar-Solares M, Zehrung D, McCarthy H, Courtenay AJ, Donnelly RF (2017) Transdermal delivery of gentamicin using dissolving microneedle arrays for potential treatment of neonatal sepsis. J Control Release 265:30–40

    Article  Google Scholar 

  32. Hiraishi Y, Nandakumar S, Choi SO, Lee JW, Kim YC, Posey JE, Sable SB, Prausnitz MR (2011) Bacillus Calmette-Guerin vaccination using a microneedle patch. Vaccine 29:2626–2636

    Article  Google Scholar 

  33. Hiraishi Y, Nakagawa T, Quan Y, Kamiyama F, Hirobe S, Okada N, Nakagawa S (2013) Performance and characteristics evaluation of a sodium hyaluronate based microneedle patch for a transcutaneous drug delivery system. Int J Pharm 441:570–579

    Article  Google Scholar 

  34. Hreczuk-Hirst D, Chicco D, German L, Duncan R (2001) Dextrins as potential carriers for drug targeting: tailored rates of dextrin degradation by introduction of pendant groups. Int J Pharm 230:57–66

    Article  Google Scholar 

  35. Hwa KY, Chang VHS, Cheng YY, Wang YD, Jan PS, Subramani BW, Wu MJ, Wang BK (2017) Analyzing polymeric matrix for fabrication of a biodegradable microneedle array to enhance transdermal delivery. Biomed Microdevices 19(4):84 (1–13)

    Article  Google Scholar 

  36. Indermun S, Luttge R, Choonara YE, Kumar P, du Toit LC, Modi G, Pillay V (2014) Current advances in the fabrication of microneedles for transdermal delivery. J Control Release 185:130–138

    Article  Google Scholar 

  37. Ito Y, Yoshimitsu JI, Shiroyama K, Sugioka N, Takada K (2006) Self-dissolving microneedles for the percutaneous absorption of EPO in mice. J Drug Target 14(5):255–261

    Article  Google Scholar 

  38. Justin R, Roman S, Chen D, Tao K, Geng X, Grant RT, MacNeil S, Sunb K, Chen B (2015) Biodegradable and conductive chitosan–grapheme quantum dot nanocomposite microneedles for delivery of both small and large molecular weight therapeutics. RSC Adv 5:51934–51946

    Article  Google Scholar 

  39. Kim S, Lee J, Shayan FL, Kim S, Huh I, Ma Y, Yang H, Kang G, Jung H (2018) Physicochemical study of ascorbic acid 2-glucoside loaded hyaluronic acid dissolving microneedles irradiated by electron beam and gamma ray. Carbohydr Polym 180:297–303

    Article  Google Scholar 

  40. Kim HK, Lee SH, Lee BY, Kim SJ, Sung CY, Jang NK, Kim JD, Jeong DH, Ryuc HY, Lee S (2018) A comparative study of dissolving hyaluronic acid microneedles with trehalose and poly(vinyl pyrrolidone) for efficient peptide drug delivery. Biomater Sci 6(10):2566–2570

    Article  Google Scholar 

  41. Kim YC, Park JH, Prausnitz MR (2012) Microneedles for drug and vaccine delivery. Adv Drug Deliv Rev 64:1547–1568

    Article  Google Scholar 

  42. Kim YC, Quan FS, Compans RW, Kang SM, Prausnitz MR (2010) Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity. J Control Release 142:187–195

    Article  Google Scholar 

  43. Kolli CS, Banga AK (2008) Characterization of solid maltose microneedles and their use for transdermal delivery. Pharma Res 25(1):104–113

    Article  Google Scholar 

  44. Kommareddy S, Baudner BC, Oh S, Kwon SY, Singh M, Ohagan DT (2012) Dissolvable microneedle patches for the delivery of cell-culture-derived influenza vaccine antigens. J Pharma Sci 101:1021–1027

    Article  Google Scholar 

  45. Koutsonanos DG, Esser ES, McMaster SR, Kalluri P, Lee JW, Prausnitz MR et al (2015) Enhanced immune responses by skin vaccination with influenza subunit vaccine in young hosts. Vaccine 33(37):4675–4682

    Article  Google Scholar 

  46. Koyani RD, Andrade M, Quester K, Gaytan P, Huerta-Sequero Vazquez-Duhalt R (2018) Surface modification of protein enhances encapsulation in chitosan nanoparticles. Appl Nanosci 8:1197–1203

    Article  Google Scholar 

  47. Lahiji SF, Dangol M, Jung H (2015) A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery. Sci Rep 5:7914

    Article  Google Scholar 

  48. Langer R (2004) Transdermal drug delivery: past progress, current status, and future prospects. Adv Drug Deliv Rev 56:557–558

    Article  Google Scholar 

  49. Larrañeta E, Lutton REM, Woolfson AD, Donnelly RF (2016) Microneedle arrays as transdermal and intradermal drug delivery systems: materials science, manufacture and commercial development. Mater Sci Eng Rep 104:1–32

    Article  Google Scholar 

  50. Lee IC, Wu YC, Tsai SW, Chen CH, Wu MH (2017) Fabrication of two-layer dissolving polyvinylpyrrolidone microneedles with different molecular weights for in vivo insulin transdermal delivery. RSC Adv 7(9):5067–5075

    Article  Google Scholar 

  51. Lee IC, Lin WM, Shu JC, Tsai SW, Chen CH, Tsai MT (2017) Formulation of two-layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice. J Biomed Mater Res 105A:84–93

    Article  Google Scholar 

  52. Lee H, Song C, Hong YS, Kim MS, Cho HR, Kang T, Shin K, Choi SH, Hyeon T, Kim DH (2017) Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module. Science 3:e1601314

    Google Scholar 

  53. Lee SG, Jeong JH, Lee KM, Jeong KH, Yang H, Kim M, Jung H, Lee S, Choi YW (2014) Nanostructured lipid carrier-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule. Int J Nanomed 9:289–299

    Google Scholar 

  54. Lee K, Lee CY, Jung H (2011) Dissolving microneedles for transdermal drug administration prepared by stepwise controlled drawing of maltose. Biomaterials 32(11):3134–3140

    Article  Google Scholar 

  55. Lee JW, Choi SO, Felner EI, Prausnitz MR (2011) Dissolving microneedle patch for transdermal delivery of human growth hormone. Small 7(4):531–539

    Article  Google Scholar 

  56. Lee W, Park JH, Prausnitz MR (2008) Dissolving microneedles for transdermal drug delivery. Biomaterials 29:2113–2124

    Article  Google Scholar 

  57. Li G, Badkar A, Nema S, Kolli CS, Banga AK (2009) In vitro transdermal delivery of therapeutic antibodies using maltose microneedles. Int J Pharma 368:109–115

    Article  Google Scholar 

  58. Ling MH, Chen MC (2013) Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats. Acta Biomater 9:8952–8961

    Article  Google Scholar 

  59. Littauer EQ, Mills LK, Brock N et al (2018) Stable incorporation of GM-CSF into dissolvable microneedle patch improves skin vaccination against influenza. J Control Release 276:1–16

    Article  Google Scholar 

  60. Liu S, Jin MN, Quan YS, Kamiyama F, Katsumi H, Sakane T, Yamamoto A (2012) The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin. J Control Release 161(3):933

    Article  Google Scholar 

  61. Liu D, Mori A, Huang L (1992) Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposome. Biochem Biophys Acta 1104:95–101

    Article  Google Scholar 

  62. Loizidou EZ, Williams NA, Barrow DA, Eaton MJ, McCrory J, Evans SL, Allender CJ (2015) Structural characterisation and transdermal delivery studies on sugar microneedles: experimental and finite element modelling analyses. Eur J Pharma Biopharma 89:224–231

    Article  Google Scholar 

  63. Luo Z, Sun W, Fang J, Lee K, Li S, Gu Z, Dokmeci MR, Khademhosseini A (2019) Biodegradable gelatin methacryloyl microneedles for transdermal drug delivery. Adv Healthc Mater 8:1801054

    Article  Google Scholar 

  64. Luzuriaga MA, Berry DR, Reagan JC, Smaldone RA, Gassensmith JJ (2018) Biodegradable 3D printed polymer microneedles for transdermal drug delivery. Lab Chip 18:1223–1230

    Article  Google Scholar 

  65. Ma G, Wu C (2017) Microneedle, bio-microneedle and bio-inspired microneedle: a review. J Control Release 251:11–23

    Article  Google Scholar 

  66. Marin A, Andrianov AK (2011) Carboxymethylcellulose–Chitosan-coated microneedles with modulated hydration properties. J Appl Polym Sci 12:395

    Article  Google Scholar 

  67. Martin CJ, Allender CJ, Brain KR, Morrissey A, Birchall JC (2012) Low temperature fabrication of biodegradable sugar glass microneedles for transdermal drug delivery applications. J Control Release 158(1):93–101

    Article  Google Scholar 

  68. Matsuo K, Yokota Y, Zhai Y, Quan YS, Kamiyama F, Mukai Y, Okada N, Nakagawa S (2012) A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens. J Control Release 161:10–17

    Article  Google Scholar 

  69. Matsuo K, Hirobe S, Yokota Y, Ayabe Y, Seto M, Quan YS (2012) Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza. J Control Release 160:495–501

    Article  Google Scholar 

  70. McGrath MG, Vucen S, Vrdoljak A, Kelly A, O’Mahony C, Crean Anne Moore AM (2014) Production of dissolvable microneedles using an atomised spray process: effect of microneedle composition on skin penetration. Eur J Pharm Biopharm 86:200–211

    Article  Google Scholar 

  71. Mistilis MJ, Bommarius AS, Prausnitz MR (2015) Development of a thermostable microneedle patch for influenza vaccination. J Pharma Sci 104:740–749

    Article  Google Scholar 

  72. Miyano T, Tobinaga Y, Kanno T, Matsuzaki Y, Takeda H, Wakui M, Hanada K (2005) Sugar micro needles as transdermic drug delivery system. Biomed Microdevices 7(3):185–188

    Article  Google Scholar 

  73. Mönkäre J, Pontier M, van Kampen EEM, Du G, Leone M, Romeijn S, Reza Nejadnik M, O’Mahony C, Slütter B, Jiskoot W, Bouwstra JA (2018) Development of PLGA nanoparticle loaded dissolving microneedles and comparison with hollow microneedles in intradermal vaccine delivery. Eur J Pharm Biopharm 129:111–121

    Article  Google Scholar 

  74. Moreira S, Da Costa RMG, Guardao L, Gartne F, Vilanova M, Gama M (2010) In vivo biocompatibility and biodegradability of dextrin-based hydrogels. J Bioact Compat Polym 25:141–153

    Article  Google Scholar 

  75. Morrow D, McCarron P, Gallagher M, Migalska K, Thakur RS, Morrissey R, Woolfson D, Donnelly R (2008) Assessment of galactose microneedles for enhanced transdermal drug delivery. J Pharma Pharma 60:A38–A39

    Google Scholar 

  76. Nguyen HX, Banga AK (2017) Fabrication, characterization and application of sugar microneedles for transdermal drug delivery. Ther Deliv 8(5):249–264

    Article  Google Scholar 

  77. Ono A, Ito S, Sakagami S, Asada H, Saito M, Quan YS, Kamiyama F, Hirobe S, Okada N (2017) Development of novel faster-dissolving microneedle patches for transcutaneous vaccine delivery. Pharmaceutics 9(3):E27

    Article  Google Scholar 

  78. Park Y, Kim B (2017) Skin permeability of compounds loaded within dissolving microneedles dependent on composition of sodium hyaluronate and carboxymethyl cellulose. Korean J Chem Eng 34(1):133–138

    Article  Google Scholar 

  79. Park Y, Kim K, Chung M, Sung JH, Kim B (2016) Fabrication and characterization of dissolving microneedle arrays for improving skin permeability of cosmetic ingredients. J Ind Eng Chem 39:121–126

    Article  Google Scholar 

  80. Park YH, Ha SK, Choi I, Kim KS, Park J, Choi N, Kim B, Sung JH (2016) Fabrication of degradable carboxymethyl cellulose (CMC) microneedle with laser writing and replica molding process for enhancement of transdermal drug delivery. Biotechnol Bioprocess Eng 21:110

    Article  Google Scholar 

  81. Park JH, Allen MG, Praunitz MR (2005) Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery. J Control Relaease 104(1):51–66

    Article  Google Scholar 

  82. Pissinato Pere CP, Sophia NE, Lall G, Ziraud C, Boateng JS, Alexander BD, Lamprou DA, Douroumis D (2018) 3D printed microneedles for insulin skin delivery. Int J Pharm 544(2):425–432

    Article  Google Scholar 

  83. Prausnitz MR, Langer R (2008) Transdermal drug delivery. Nat Biotechnol 26:1261–1268

    Article  Google Scholar 

  84. Prausnitz MR, Mitragotri S, Langer R (2004) Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov 3:115–124

    Article  Google Scholar 

  85. Quan FS, Kim YC, Yoo DG, Compans RW, Prausnitz MR, Kang SM (2009) Stabilization of influenza vaccine enhances protection by microneedle delivery in the mouse skin. PLoS One 4:e7152

    Article  Google Scholar 

  86. Raphael AP, Crichton ML, Falconer RJ, Chen SMX, Fernando GJP, Huang H, Kendall MAF (2016) Formulations for microprojection/microneedle vaccine delivery: structure, strength and release profiles. J Control Release 225:40–52

    Article  Google Scholar 

  87. Raphael AP, Prow TW, Crichton ML, Chen X, Fernando GJ, Kendall MA (2010) Targeted, needle-free vaccinations in skin using multilayered, densely-packed dissolving microprojection arrays. Small 6:1785

    Article  Google Scholar 

  88. Ryota N, Hirofumi M, Shigeki T (2017) A novel microneedle device having flexible substrate and strong needles using PVA and gelatin. Internat. In: Symposium micro-nano mechatronics human science (MHS), Nagoya, pp 1–6

  89. Sachiko H, Risa O, Hiroshi I, Ying Q, Fumio K, Hideo A, Naoki O, Shinsaku N (2017) Clinical study of a retinoic acid-loaded microneedle patch for seborrheic keratosis or senile lentigo. Life Sci 168:24–27

    Article  Google Scholar 

  90. Schipper P, van der Maaden K, Groeneveld V, Ruigrok M, Romeijn S, Uleman S, Omens CO, Kersten G, Jiskoot W, Bouwstra J (2017) Diphtheria toxoid and N-trimethyl chitosan layer-by-layer coated pH-sensitive microneedles induce potent immune responses upon dermal vaccination in mice. J Control Release 262:28–36

    Article  Google Scholar 

  91. Sullivan SP, Koutsonanos DG, Martin MP, Lee JW, Zarnitsyn V, Murthy N, Compans RW, Skountzou I, Prausnitz MR (2010) Dissolving polymer microneedle patches for influenza vaccination. Nat Med 16(8):915–920

    Article  Google Scholar 

  92. Sun W, Araci Z, Inayathullah M, Manickam S, Zhang X, Bruce MA, Marinkovich MP, Lane AT, Milla C, Rajadas J, Butte M (2013) Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications. Acta Biomater 9(8):7767–7774

    Article  Google Scholar 

  93. Takakura Y, Hashida M (1995) Macromolecular drug carrier systems in cancer chemotherapy: macromolecular prodrugs. Crit Rev Oncol Hematol 18:207–231

    Article  Google Scholar 

  94. Tsai YS, Chen MY, Lan SK, Tsai HT, Chen MC, Tzai TS (2017) Transdermal delivery of leuprolide acetate with chitosan microneedles: a promising tool for androgen deprivation therapy. Eur Urol Suppl 16(3):e130

    Article  Google Scholar 

  95. Vassilieva EV, Kalluri H, McAllister D, Taherbhai MT, Esser ES, Pewin WP et al (2015) Improved immunogenicity of individual influenza vaccine components delivered with a novel dissolving microneedle patch stable at room temperature. Drug Deliv Transl Re 5(4):360–371

    Article  Google Scholar 

  96. Wang QL, Zhu DD, Liu XB, Chen BZ, Guo XD (2016) Microneedles with controlled bubble sizes and drug distributions for efficient transdermal drug delivery. Sci Rep 6:38755

    Article  Google Scholar 

  97. Wang C, Yangi Y, Gabrielle MH, Sadeghifar H, Gu Z (2016) Enhanced cancer immunotherapy by microneedle patch-assisted delivery of anti-PD1 antibody. Nano Lett 16(4):2334–2340

    Article  Google Scholar 

  98. Wang QL, Zhu DD, Chen Y, Guo XD (2016) Fabrication method of microneedle molds with controlled microstructures. Mater Sci Eng C 65(1):135–142

    Article  Google Scholar 

  99. Weldon WC, Martin MP, Zarnitsyn V, Wang B, Koutsonanos D, Skountzou I, Prausnitz MR, Compans RW (2011) Microneedle vaccination with stabilized recombinant influenza virus hemagglutinin induces improved protective immunity. Clin Vaccine Immunol 18:647–654

    Article  Google Scholar 

  100. Widera G, Johnson J, Kim L, Libiran L, Nyam K, Daddona PE, Cormier M (2006) Effect of delivery parameters on immunization to ovalbumin following intracutaneous administration by a coated microneedle array patch system. Vaccine 24:1653–1664

    Article  Google Scholar 

  101. Wu X, Chen Y, Gui S, Wu X, Chen L, Cao Y, Yin D, Ping M (2016) Sinomenine hydrochloride-loaded dissolving microneedles enhanced its absorption in rabbits. Pharm Dev Technol 21(7):787–793

    Google Scholar 

  102. Wu D, Quan YS, Kamiyama F, Kusamori K, Katsumi H, Sakane T, Yamamoto A (2015) Improvement of transdermal delivery of sumatriptan succinate using a novel self-dissolving microneedle array fabricated from sodium hyaluronate in rats. Biol Pharm Bull 38:365–373

    Article  Google Scholar 

  103. Xie Y, Xu B, Gao Y (2005) Controlled transdermal delivery of model drug compounds by MEMS microneedle array. Nanomed Nanotechnol Biol Med 1:184–190

    Article  Google Scholar 

  104. Yu W, Jiang G, Zhang Y, Liu D, Xu B, Zhou J (2017) Polymer microneedles fabricated from alginate and hyaluronate for transdermal delivery of insulin. Mater Sci Eng C 80:1987–1996

    Article  Google Scholar 

  105. Yu W, Jiang G, Liu D, Li L, Chen H, Liu Y, Huang Q, Tong Z, Yao J, Kong X (2017) Fabrication of biodegradable composite microneedles based on calcium sulfate and gelatin for transdermal delivery of insulin. Mater Sci Eng C 71:725–734

    Article  Google Scholar 

  106. Yu W, Jiang G, Liu D, Li L, Tong Z, Yao J, Kong X (2017) Transdermal delivery of insulin with bioceramic composite microneedles fabricated by gelatin and hydroxyapatite. Mater Sci Eng C 73:425–428

    Article  Google Scholar 

  107. Yu J, Zhang Y, Ye Y, DiSanto R, Sun W, Ranson D, Ligler FS, Busec JB, Gu Z (2015) Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery. PNAS 112(27):8260–8265

    Article  Google Scholar 

  108. Yu J, Qian C, Zhang Y, Cui Z, Zhu Y, Shen Q, Ligler FS, Buse JB, Gu Z (2017) Hypoxia and H2O2 dual-sensitive vesicles for enhanced glucoseresponsive insulin delivery. Nano Lett 17:733–739

    Article  Google Scholar 

  109. Zhang Y, Jiang G, Yu W, Liu D, Xua B (2018) Microneedles fabricated from alginate and maltose for transdermal delivery of insulin on diabetic rats. Mater Sci Eng C 85:18–26

    Article  Google Scholar 

  110. Zhang JN, Chen BZ, Ashfaq M, Zhang XP, Guo XD (2018) Development of a BDDE-crosslinked hyaluronic acid based microneedles patch as a dermal filler for anti-ageing treatment. J Ind Eng Chem 65:363

    Article  Google Scholar 

  111. Zhong H, Chan G, Hu Y, Hu H, Ouyang D (2018) A comprehensive map of FDA-approved pharmaceutical products. Pharmaceutics 10:263

    Article  Google Scholar 

  112. Zhu Z, Ye X, Ku Z, Liu Q, Shen C, Luo H (2016) Transcutaneous immunization via rapidly dissolvable microneedles protects against hand-foot-and-mouth disease caused by enterovirus 71. J Control Release 243:291–302

    Article  Google Scholar 

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  1. School of Pharmacy, The University of Texas at El Paso, 500 W University Ave, El Paso, TX, 79968, USA

    Rina D. Koyani

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Koyani, R.D. Biopolymers for microneedle synthesis: from then to now. Biomanuf Rev 4, 1 (2019). https://doi.org/10.1007/s40898-019-0006-8

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