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Emerging Application of Nanocelluloses for Microneedle Devices

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Handbook of Nanocelluloses

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Abstract

In quest of an efficient delivery system and for accurate delivery of drug to the ailment site, various researchers focused on development of a versatile delivery system. In progression, investigations on novel materials gained spotlight to add new dimension in the delivery devices to provide a more compatible and innovative platform for drug delivery. For innovative delivery systems, biomaterials like nanocelluloses were exploited for designing various scaffolds and delivery devices like microneedles. Microneedle devices are current trends of drug delivery where nanocellulose has evolved as protagonist for delivery aspects and strengthen the structural integrity of device. Nanocelluloses provided a wide choice for polymers to design biodegradable microneedle device. Nanocellulose also offers wide scope in surface engineering to upsurge the applicability of polymer for desired functionality of microneedle device.

This chapter detailed the advances in microneedle exploiting nanocellulose or their combinations as well as it also illuminates current research efforts focusing on production of nanocelluloses and application for microneedle devices and their anticipated prospects.

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Abbreviations

2-[HEA]- [HSO4]:

2-hydroxyethylammonium hydrogen sulfate

AmimCl:

1-allyl-3 methylimidazolium chloride

BC:

Bacterial Cellulose

BM:

Bone marrow

BmimCl:

1-butyl- 3 methylimidazolium chloride

BmimHSO4:

1-butyl-3-methylimidazolium hydrogen sulfate

BmimOAc:

1-allyl-3 methylimidazolium chloride

BNC:

Bacterial Nanocellulose

CMC:

Carboxymethyl cellulose

CMF:

Cellulose microfibrils

CNF:

Cellulose nanofibrils

Co2+:

Cobaltous cation

Co(NO3)2:

Cobalt nitrate

Cr(NO3)3:

Chromium(III) nitrate

d:

Particle size

DMAc:

Dimethyl sulfoxide

DP:

Degree of Polymerization

Fe3+:

Ferric ion

Fe(NO3)3:

ferric nitrate

H3O+:

Hydronium ion

HBr:

Hydrogen bromide

HCl:

Hydrochloric acid

HPH:

High Pressure Homogenization

H3PO4:

Phosphoric acid

H2SO4:

Sulphuric acid

HS:

Hestrin-Schramm

ILs:

Ionic liquids

IPN:

Interpenetrating network

KGy:

Kilogray

MCC:

Microcrystalline cellulose

MimHSO4:

1-butyl-3 methylimidazolium hydrogen sulfate

MN:

Microneedle

MPa:

Megapascal

MTS:

Microstructured transdermal system

NaBr:

Sodium Bromide

NaClO:

Sodium hypochlorite

NaClO2:

Sodium chlorite

NaOH:

Sodium hydroxide

NCC:

Nanocrystalline Cellulose

NFC:

Nanofibtillar cellulose.

Ni2+:

Nickelous ion

nm:

nanometer

Ni(NO3)2:

Nickel nitrate

OP:

Organophosphate

OPi:

Opioid

P:

Pressure of homogenizer

PFI:

Papirindustriens Forsknings institutt

PVA:

Poly vinyl alcohol

PVP:

Poly vinylpyrrolidone

rpm:

Revolutions per minute

SF:

Silk fibroin

TBAA:

Tetrabutylammonium acetate

TEMPO:

2,2,6,6 tetramethylpiperidine-1-oxyl

UV:

Ultra-violet

ZP:

Zosano Pharma

γ:

Gamma

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Author information

Authors and Affiliations

  1. Lab for Multimolar Biomedical Imaging and Therapy, University of Science and Technology of China, Hefei, China

    Monika Dwivedi, Shuwei Shen, Pankaj Dwivedi & Xu Xiarong

  2. Department of Pharmacy, Pranveer Singh Institute of Technology (PSIT), Kanpur, India

    Jyotsana Dwivedi

  3. Anhui Medical University, Hefei, China

    Liu Guangli

Authors
  1. Monika Dwivedi
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  2. Jyotsana Dwivedi
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  3. Shuwei Shen
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  4. Pankaj Dwivedi
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  5. Liu Guangli
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  6. Xu Xiarong
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Corresponding author

Correspondence to Xu Xiarong .

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Editors and Affiliations

  1. NanoStruc Research Group Chemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt

    Ahmed Barhoum

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Dwivedi, M., Dwivedi, J., Shen, S., Dwivedi, P., Guangli, L., Xiarong, X. (2022). Emerging Application of Nanocelluloses for Microneedle Devices. In: Barhoum, A. (eds) Handbook of Nanocelluloses. Springer, Cham. https://doi.org/10.1007/978-3-030-89621-8_33

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