Abstract
Cancer is one of the main causes of morbidity and mortality. Although a number of techniques are available for treatment, these methods still have a number of drawbacks, destroying healthy tissues and cells to cause various side effects. Here we present the synthesis and biological application of a composite nanomaterial, folic acid (FA)-conjugated graphene oxide (GO) nanosheets functionalized with manganese dioxide (MnO2) nanoparticles. While FA-conjugated GO nanosheets can be used for targeted photothermal therapy (PTT) when irradiated with a near infrared (NIR) light, MnO2 nanoparticles degrade hydrogen peroxide (H2O2) in the cancer microenvironment, countering hypoxia. Further the nanoparticles can be used as a contrast agent in MRI imaging. We demonstrated that MnO2-FA-GO nanosheets were uptaken by HeLa cells overexpressing FA receptors to induce NIR irradiation-mediated hyperthermia (35% viability). Therefore, this composite MnO2-FA-GO nanosheet could be a powerful carrier for cancer targeting and PTT applications.
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Acknowledgments: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (Grant number HI14C3347). This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science and ICT (MSIT) (Grant number 2015M3A9D7030461). This work was also supported by Leading Foreign Research Institute Recruitment Program through the NRF funded by the MSIT (Grant number 2013K1A4A3055268).
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Lim, J.H., Kim, D.E., Kim, EJ. et al. Functional Graphene Oxide-Based Nanosheets for Photothermal Therapy. Macromol. Res. 26, 557–565 (2018). https://doi.org/10.1007/s13233-018-6067-3
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DOI: https://doi.org/10.1007/s13233-018-6067-3