Abstract
We synthesized pH-responsive chitosan-coated mesoporous silica nanoparticles. The morphological characterization conveyed that the mesoporous silica was encapsulated within pH-responsive cationic chitosan. Further, the average diameter of chitosan-coated mesoporous silica nanoparticles was approximately 230 nm. The doxorubicin, an anticancer drug, was loaded into the cavities of mesoporous chitosan-coated silica nanoparticles. pH played an important role in regulating the release of doxorubicin from chitosan-coated mesoporous silica nanoparticles, indicating that 53% and 90% doxorubicin were released from chitosan-coated mesoporous silica nanoparticles within 48 h at pH 7.4 and pH 4.4, respectively. We also demonstrated the endocytosis of chitosan-coated mesoporous silica nanoparticles in MCF-7 breast cancer cells. Therefore, this chitosan-coated mesoporous silica nanoparticle could be a powerful tool for pH-responsive controlled release of the anticancer drug.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
P. S. Stayton, T. Shimoboji, C. Long, A. Chilkoti, G. Ghen, J. M. Harris, and A. S. Hoffman, Nature, 378, 472 (1995).
D. Roy, J. N. Cambre, and B. S. Sumerlin, Prog. Polym. Sci., 35, 278 (2010).
N. Bhattarai, J. Gunn, and M. Zhang, Adv. Drug Deliv. Rev., 62, 83 (2010).
Y. S. Lin and C. L. Haynes, J. Am. Chem. Soc., 132, 4834 (2010).
I. I. Slowing, B. G. Trewyn, and V. S. Y. Lin, J. Am. Chem. Soc., 129, 8845 (2007).
S. C. Warren, F. J. DiSalvo, and U. Wiesner, Nat. Mater., 6, 156 (2007).
Y. Zhu, J. Shi, W. Shen, X. Dong, J. Feng, M. Ruan, and Y. Li, Angew. Chem. Int. Ed., 44, 5083 (2005).
X. Jiang, T. L. Ward, Y. S. Cheng, J. Liu, and C. J. Brinker, Chem. Commun., 46, 3019 (2010).
J. Zhu, J. Tang, L. Zhao, X. Zhou, Y. Wang, and C. Yu, Small, 6, 276 (2010).
C. E. Ashley, E. C. Carnes, G. K. Phillips, D. Padilla, P. N. Durfee, P. A. Brown, T. N. Hanna, J. Liu, B. Phillips, M. B. Carter, N. J. Carroll, X. Jiang, D. R. Dunphy, C. L. Willman, D. N. Petsev, D. G. Evans, A. N. Parikh, B. Chackerian, W. Wharton, D. S. Peabody, and C. J. Brinker, Nat. Mater., 10, 389 (2011).
M. Gary-Bobo, O. Hocine, D. Brevet, M. Maynadier, L. Raehm, S. Richeter, V. Charasson, B. Loock, A. Morère, P. Maillard, M. Garcia, and J. O. Durand, Int. J. Pharm., 423, 509 (2012).
S. H. Cheng, C. H. Lee, C. S. Yang, F. G. Tseng, C. Y. Mou, and L. W. Lo, J. Mater. Chem., 19, 1252 (2009).
A. J. Di Pasqua, K. K. Sharma, Y. L. Shi, B. B. Toms, W. Ouellette, J. C. Dabrowiak, and T. Asefa, J. Inorg. Biochem., 102, 1416 (2008).
W. Lin, Y. W. Huang, X. D. Zhou, and Y. Ma, Toxicol. Appl. Pharm., 217, 252 (2006).
L. Sun, Y. Li, X. Liu, M. Jin, L. Zhang, Z. Du, C. Guo, P. Huang, and Z. Sun, Toxicol. In Vitro, 25, 1619 (2011).
D. Napierska, L. C. J. Thomassen, V. Rabolli, D. Lison, L. Gonzalez, M. Kirsch-Volders, J. A. Martens, and P. H. Hoet, Small, 5, 846 (2009).
T. Xia, M. Kovochich, M. Liong, H. Meng, S. Kabehie, S. George, J. I. Zink, and A. E. Nel, ACS Nano, 3, 3273 (2009).
R. Liu, P. Liao, J. Liu, and P. Feng, Langmuir, 27, 3095 (2011).
J. H. Jang, Y. M. Choi, Y. Y. Choi, M. K. Joo, M. H. Park, B. G. Choi, E. Y. Kang, and B. Jeong, J. Mater. Chem., 21, 5484 (2011).
Z. Deng, Z. Zhen, X. Hu, S. Wu, Z. Xu, and P. K. Chu, Biomaterials, 32, 4976 (2011).
J. Wu, Z.-G. Su, and G.-H. Ma, Int. J. Pharm., 315, 1 (2006).
J. Wu and M. J. Sailor, Adv. Funct. Mater., 19, 733 (2009).
Y. Wan and D. Zhao, Chem. Rev., 107, 2821 (2007).
J. Rejman, V. Oberle, I. S. Zuhorn, and D. Hoekstra, Biochem. J., 377, 159 (2004).
M. Gulfam, J. Kim, J. M. Lee, B. Ku, B. H. Chung, and B. G. Chung, Langmuir, 28, 8216 (2012).
H. Ge, Y. Hu, X. Jiang, D. Cheng, Y. Yuan, H. Bi, and C. Yang, J. Pharm. Sci., 91, 1463 (2002).
S. W. Song, K. Hidajat, and S. Kawi, Chem. Commun., 4396 (2007).
F. Danhier, O. Feron, and V. Préat, J. Control. Release, 148, 135 (2010).
Author information
Authors and Affiliations
Corresponding author
Additional information
The image from this article is used as the cover image of the Volume 22, Issue 4.
Rights and permissions
About this article
Cite this article
Gulfam, M., Chung, B.G. Development of pH-responsive chitosan-coated mesoporous silica nanoparticles. Macromol. Res. 22, 412–417 (2014). https://doi.org/10.1007/s13233-014-2063-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13233-014-2063-4