Abstract
Thyroid carcinoma is a common endocrine organ cancer associated with abnormal hormone secretion, leading to the disorder of metabolism. The intestinal microbiota is vital to maintain digestive and immunologic homeostasis. The relevant information of the microbial community in the gut and thyroid, including composition, structure, and relationship, is unclear in thyroid carcinoma patients. A total of 93 samples from 25 patients were included in this study. The results showed that microbial communities existed in thyroid tissue; gut and thyroid had high abundance of facultative anaerobes from the Proteobacteria phyla. The microbial metabolism from the thyroid and gut may be affected by the thyroid carcinoma cells. The cooccurrence network showed that the margins of different thyroid tissues were unique areas with more competition; the stabilization of microcommunities from tissue and stool may be maintained by several clusters of species that may execute different vital metabolism processes dominantly that are attributed to the microenvironment of cancer.
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Acknowledgements
This study was supported by the Yunnan Province Innovation Team of Intestinal Microecology Related Disease Research and Technological Transformation (China) (202005AE160010) and Yunnan Digestive Endoscopy Clinical Medical Center Foundation for Health Commission of Yunnan Province (2019LCZXKF-XH01).
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The protocol for the original treatment study was approved by the Medical ethics committee of Kunming University of Science and Technology (number: KMUST-MEC-081). All research methods were performed by the relevant guidelines and regulations. For the consent process, we contacted patients or their family members and explained the study in detail.
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Liu, CJ., Chen, SQ., Zhang, SY. et al. The comparison of microbial communities in thyroid tissues from thyroid carcinoma patients. J Microbiol. 59, 988–1001 (2021). https://doi.org/10.1007/s12275-021-1271-9
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DOI: https://doi.org/10.1007/s12275-021-1271-9