Abstract
Here we present Bacillus subtilis as a model system to study protein homeostasis and protein quality control in conjunction with the different layers of its stress response systems. We established a new marker to study protein aggregation in vivo. Furthermore, we observed that the transcription factor Spx, which has already been characterized as a central player to activate transcription of redox-chaperones during heat shock and oxidative stress response, was also able to simultaneously inhibit the transcription of translation-related genes as a second response to stress.
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Ingo Hantke 2010–2015 Life-Science-Studium mit Schwerpunkt Molekularbiologie und Bioprozesstechnik an der Universität Hannover. Seit 2015 Doktorand am Institut für Mikrobiologie im Rahmen der Hannover School for Biomolecular Drug Research (HSBDR).
Heinrich Schäfer 2008–2013 Biologiestudium, Schwerpunkt Molekularbiologie und Biochemie an der Universität Greifswald. Seit 2013 Doktorand am Institut für Mikrobiologie an der Universität Hannover.
Regina Kramer 2010–2015 Pflanzenbiotechnologiestudium an der Universität Hannover. Seit 2015 Doktorandin am Institut für Mikrobiologie an der Universität Hannover.
Kürşad Turgay Chemiestudium an der TU Berlin. 1991–1994 Promotion an der Universität Marburg bei Prof. Dr. M. Marahiel. 1995–1999 Postdoc am Public Health Research Institute in New York, USA, bei Prof. Dr. D. Dubnau. 1999–2004 Projektleiter bei Prof. Dr. B. Bukau an der Universität Freiburg und am ZMBH der Universität Heidelberg. 2004–2010 Juniorprofessor und 2010–2011 Heisenberg-Stipendiat der DFG an der FU Berlin. Seit 2011 Professor für Mikrobiologie (W2) an der Universität Hannover.
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Hantke, I., Schäfer, H., Kramer, R. et al. Das stressige Leben des Bacillus subtilis. Biospektrum 25, 150–152 (2019). https://doi.org/10.1007/s12268-019-1023-0
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DOI: https://doi.org/10.1007/s12268-019-1023-0