Abstract
Ciprofloxacin-loaded poly(vinylpyrrolidinone) (PVP) and dextran sulfate (Dex) (PVP/Dex) nanofibers were prepared using the emulsion electrospinning method. The physical and morphological characteristics of the prepared nanofibers were evaluated by conducting a Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). The polymer-polymer and polymer-drug interactions were determined using differential scanning calorimetry (DSC). Moreover, the formation of the core-shell structure was confirmed by transmission electron microscopy (TEM) and confocal laser microscopy. The sustained release behavior was evaluated using ultraviolet-visible (UV-vis) spectroscopy, and its kinetic mechanism was investigated using Korsmeyer-Peppas, Peppas-Sahlin, and Weibull models by a non-linear regression equation. The antibacterial properties were evaluated using the disc diffusion method with respect to several wound gram-positive (Methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Staphylococcus aureus, and Klebsiella pneumoniae) and gram-negative bacteria (Pseudomonas aeruginosa, Salmonella typhimurium, and Proteus vulgaris). In general, the release behavior of Ciprofloxacin from PVP/Dex is controlled by diffusion in the delivery system.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
M. S. Khil, D. I. Cha, H. Y. Kim, I. S. Kim, and N. Bhattarai, J. Biomed. Mater. Res. B Appl. Biomater., 67, 675 (2003).
L. A. Smith, X. Liu, and P. X. Ma, Soft Matter., 4, 2144 (2008).
Y. K. Luu, K. Kim, B. S. Hsiao, B. Chu, and M. Hadjiargyrou, J. Control. Release, 89, 341 (2003).
H. Jiang, Y. Hu, Y. Li, P. Zhao, K. Zhu, and W. Chen, J. Control. Release, 108, 237 (2005).
F. Zheng, S. Wang, S. Wen, M. Shen, M. Zhu, and X. Shi, Biomaterials, 34, 1402 (2013).
G. Yang, J. Wang, Y. Wang, L. Li, X. Guo, and S. Zhou, ACS Nano, 9, 1161 (2015).
G. Yang, X. Li, Y. He, J. Ma, G. Ni, and S. Zhou, Prog. Polym. Sci., 81, 80 (2018).
Y. Gao, Y. Bach Truong, Y. Zhu, and I. L. Kyratzis, J. Appl. Polym. Sci., 131, 40797 (2014).
K. A. Rieger, N. P. Birch, and J. D. Schiffman, Carbohydr. Polym., 139, 131 (2016).
C. Li, R. Fu, C. Yu, Z. Li, H. Guan, D. Hu, D. Zhao, and L. Lu, Int. J. Nanomed., 8, 4131 (2013).
C. Han, N. Cai, V. Chan, M. Liu, X. Feng, and F. Yu, Colloids Surf. A: Physicochem. Eng. Asp., 559, 104 (2018).
A. R. Unnithan, N. A. Barakat, P. B. Pichiah, G. Gnanasekaran, R. Nirmala, Y. S. Cha, C. H. Jung, M. H. El-Newehy, and H. Y. Kim, Carbohydr. Polym., 90, 1786 (2012).
K. Raghunath, K. P. Rao, B. Nagarajan, and K. T. Joseph, Eur. Polym. J., 21, 195 (1985).
A. L. Yarin, Polym. Adv. Technol., 22, 310 (2011).
N. Cai, C. Han, X. Luo, G. Chen, Q. Dai, and F. Yu, Macromol. Mater. Eng., 302, 1600364 (2017).
C. Liu, K. G. H. Desai, X. Tang, and X. Chen, Dry. Technol., 24, 769 (2006).
L. Serra, J. Doménech, and N. A. Peppas, Biomaterials, 27, 5440 (2006).
J. Siepmann and N. A. Peppas, Adv. Drug Deliv. Rev., 48, 139 (2001).
Y. Fu and W. J. Kao, Expert Opin. Drug Deliv., 7, 429 (2010).
C. Vineis and A. Varesano (Eds.), Natural Polymer-based Electrospun Fibers for Antibacterial Uses, In: Electrofluidodynamic Technologies (EFDTs) for Biomaterials and Medical Devices - Principles and Advances, Woodhead Publishing Series in Biomaterials, 275 (2018).
O. Bshena, T. Heunis, L. M. Dicks, and B. Klumperman, Future. Med. Chem., 3, 1821 (2011).
Y. Su, Q. Su, W. Liu, M. Lim, J. R. Venugopal, X. Mo, S. Ramakrishna, S. S. Al-Deyab, and M. H. El-Newehy, Acta Biomater., 8, 763 (2012).
A. M. Moydeen, M. S. A. Padusha, E. F. Aboelfetoh, S. S. Al-Deyab, and M. H. El-Newehy, Int. J. Biol. Macromol., 116, 1250 (2018).
Z. Sun, E. Zussman, A. L. Yarin, J. H. Wendorff, and A. Greiner, Adv. Mater., 15, 1929 (2003).
T. Roy, P. P. Maity, A. P. Rameshbabu, B. Das, A. John, A. Dutta, S. K. Ghorai, S. Chattopadhyay, and S. Dhara, Bioengineering, 5, 68 (2018).
D. G. Yu, X. X. Shen, C. Branford-White, K. White, L. M. Zhu, and S. W. Bligh, Nanotechnology, 20, 055104 (2009).
G. M. Kim, K. H. Le, S. M. Giannitelli, Y. J. Lee, A. Rainer, and M. Trombetta, J. Mater. Sci. Mater. Med., 24, 1425 (2013).
Y. S. Kumar, A. R. Unnithan, D. Sen, C. S. Kim, and Y. S. Lee, Colloids Surf. A: Physicochem. Eng. Asp., 477, 77 (2015).
D. Mondal, M. M. R. Mollick, B. Bhowmick, D. Maity, M. K. Bain, D. Rana, A. Mukhopadhyay, K. Dana, and D. Chattopadhyay, Prog. Nat. Sci.: Mater. Int., 23, 579 (2013).
Y. Fu, X. Li, C. Sun, Z. Ren, W. Weng, C. Mao, and G. Han, ACS Appl. Mater. Interf., 7, 25514 (2015).
M. S. Birajdar and J. Lee, Chem. Eng. Sci., 288, 1 (2016).
T. T. N. Thuy, C. Ghosh, S. G. Hwang, N. Chanunpanich, and J. S. Park, Int. J. Pharm., 439, 296 (2012).
Y. Shi, Z. Wei, H. Zhao, T. Liu, A. Dong, and J. Zhang, J. Nanosci. Nanotechnol., 13, 3855 (2013).
R. Gouda, H. Baishya, and Z. Qing, J. Devel. Drugs, 6, 1000171 (2017).
N. A. Peppas, Pharm. Acta Helv., 60, 110 (1985).
F. Rehman, P. L. O. Volpe, and C. Airoldi, Coll. Surf. B: Biointerfaces, 119, 82 (2014).
Q.-Z. Zhai, Mater. Sci. Eng. C, 32, 2411 (2012).
N. A. Peppas and J. J. Sahlin, Int. J. Pharm., 57, 169 (1989).
J. M. Unagolla and A. C. Jayasuriya, Eur. J. Pharm. Sci., 114, 199 (2018).
A. Azadi, M. Hamidi, and M.-R. Rouini, Int. J. Biol. Macromol., 62, 523 (2013).
P. Costa and J. M. S. Lobo, Eur. J. Pharm. Sci., 13, 123 (2001).
S. Dash, P. N. Murthy, L. Nath, and P. Chowdhury, Acta Pol. Pharm., 67, 217 (2010).
K. H. Ramteke, P. A. Dighe, A. R. Kharat, and S. V. Patil, Sch. Acad. J. Pharm., 3, 388 (2014).
J. Mukherjee, P. T. Wong, S. Tang, K. Gam, A. Coulter, J. R. Baker, and S. K. Choi, Mol. Pharm., 12, 4498 (2015).
K. J. Carroll, Control. Clin. Trials, 24, 682 (2003).
A. Giacometti, O. Cirioni, A. M. Schimizzi, M. S. Del Prete, F. Barchiesi, M. M. D’Errico, E. Petrelli, and G. Scalise, J. Clin. Microbiol., 38, 918 (2000).
A. Mohammed, M. E. Seid, T. Gebrecherkos, M. Tiruneh, and F. Moges, Int. J. Microbiol., 2017, 8953829 (2017).
Acknowledgement
This project was supported by Researchers Supporting Project Number (RSP-2019/65), King Saud University, Riyadh, Saudi Arabia.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Moydeen, A.M., Padusha, M.S.A., Thamer, B.M. et al. Single-nozzle Core-shell Electrospun Nanofibers of PVP/Dextran as Drug Delivery System. Fibers Polym 20, 2078–2089 (2019). https://doi.org/10.1007/s12221-019-9187-2
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12221-019-9187-2