Abstract
Purpose of Review
Maintaining positive health behaviours promotes better health outcomes for people with type 1 diabetes (T1D). However, implementing these behaviours may also lead to additional management burdens and challenges. Diabetes technologies, including continuous glucose monitoring systems, automated insulin delivery systems, and digital platforms, are being rapidly developed and widely used to reduce these burdens. Our aim was to review recent evidence to explore the influence of these technologies on health behaviours and well-being among adults with T1D and discuss future directions.
Recent Findings
Current evidence, albeit limited, suggests that technologies applied in diabetes self-management education and support (DSME/S), nutrition, physical activity (PA), and psychosocial care areas improved glucose outcomes. They may also increase flexibility in insulin adjustment and eating behaviours, reduce carb counting burden, increase confidence in PA, and reduce mental burden.
Summary
Technologies have the potential to promote health behaviours changes and well-being for people with T1D. More confirmative studies on their effectiveness and safety are needed to ensure optimal integration in standard care practices.
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
Introduction
More than 8.4 million individuals live with type 1 diabetes (T1D) globally, and the prevalence is projected to double by 2040 [1]. T1D is an autoimmune disease characterized by the destruction of pancreatic beta cells, leading to insulin deficiency, hyperglycaemia, and subsequent microvascular and macrovascular complications [2]. The aim of T1D management is to effectively deliver exogenous insulin to maintain normoglycemia in order to prevent diabetes-related complications while minimizing its psychosocial burden [3]. A recent guideline points out that to achieve these aims, cultivating positive health behaviours and promoting psychological well-being are fundamental [4]. Specifically, five areas warrant attention: diabetes self-management education and support (DSME/S), medical nutrition therapy, routine physical activity (PA), tobacco cessation counselling, and psychosocial care [4]. Integrating these strategies into daily T1D management, however, could become a substantial burden to many people living with T1D (PwT1D).
To reduce this burden, diabetes technologies are being rapidly developed and have been widely adopted across the globe [5,6,7,8,9,10]. These technologies can assist PwT1D with their self-management, including lifestyle modifications, glucose monitoring, and therapy adjustments [4]. Wearable technologies are revolutionizing diabetes care, and one example is the continuous glucose monitoring (CGM) systems which measure interstitial glucose and provide continuous information on glucose profile and dysglycaemia alerts [11]. Combination of continuous subcutaneous insulin infusion (CSII) and CGM forms sensor-augmented pump (SAP) which allows predictive low-glucose suspend feature, further reducing risks of hypoglycemia [12]. Automated insulin delivery (AID) systems, combining CGM, CSII, and a control algorithm, can automatically modulate insulin infusion to address both hypoglycaemia and hyperglycemia [13]. In this review, AID refers to single-hormone hybrid closed-loop systems, unless specified. Beyond wearable technologies, digital platforms including websites, software, and mobile applications (app) have been developed to facilitate diabetes education and support, insulin dose estimations, carb counting (CC), etc.
We reviewed recent literature (published within the past 5 years until April 2023) to explore the influence of these advanced technologies on health behaviours and psychological well-being among non-pregnant adults with T1D, and discuss future directions. We also searched the International Clinical Trials Registry for ongoing trials. A complete methodology of search strategies can be found in supplementary material 1.
Diabetes Self-Management Education and Support
The aim of DSME/S is to provide evidenced-based information and strategies to support and educate PwT1D in various aspects of diabetes management, empowering PwT1D to make confident decisions, engage in self-care behaviours, and sustain self-management [14]. Examples of technology used in DSME/S interventions include short message services, mobile and/or web apps, and social media platforms. Compared to in-person approaches, the strength of digital DSME/S interventions include increased accessibility for a larger proportion of PwT1D and availability of information at any time [15], no travel time and decreased sense of stigmatization [16]. In this section, only technologies targeting multiple positive health behaviours are considered; otherwise, they are discussed in relevant sections below.
Influence of digital DSME/S use on health outcomes varies among interventions, due to the format of delivery, type of features, program length, and population. For instance, TangTangQuan is a free mobile DSME/S app for PwT1D in China, composed of four components: personal diabetes diary, dietary panel, diabetes education modules, and a peer support community. A longitudinal cohort study including 693 adults with T1D suggested that relative to baseline, glycaemic improvements were observed after 12 months of app use (HbA1c: 6.9 ± 1.3% vs. 6.6 ± 1.3%, p < 0.001; fasting blood glucose: 7.57 ± 2.28 mmol/L vs. 7.22 ± 2.40 mmol/L, p = 0.006; postprandial blood glucose: 8.35 ± 2.25 mmol/L vs. 8.06 ± 2.47 mmol/L, p = 0.021), especially among those more engaged in peer support [17••]. Other examples of digital DSME/S interventions being investigated are the Support platform [18]. Support is a self-guided free online web app, including learning modules, discussion forums, and virtual reward points, for PwT1D in Canada. A prospective study is ongoing to evaluate users’ satisfaction, engagement, and efficacy to change the fear and the frequency of hypoglycaemia among adult PwT1D (NCT04233138) [19].
Medical Nutrition Therapy
International guidelines recommend medical nutrition therapy provided by a registered dietitian as part of diabetes care [20,21,22]. However, adopting a specialized diet (e.g., low carbohydrate) or tracking intake (e.g., CC) can amplify the burden of diabetes management. New technologies can reduce these challenges to reach treatment goals.
Wearable Technologies
A main challenge around insulin adjustments is hypoglycaemia, a common complication mainly treated with simple carbohydrates [23]. Recent literature shows significant reduction of hypoglycaemic events with the use of wearable technology [24]. In a sample of adults with T1D treated by multiple daily injections (MDI), real-time CGM (rt-CGM) users were more proactive in preventing level-2 hypoglycaemia (defined as ≤ 3.0 mmol/L) by taking carbohydrates at a higher glucose threshold (4.4 ± 0.8 vs 3.9 ± 0.8; p = 0.005) [25••]. SAP users also reported needing less carbohydrates to treat hypoglycaemia, owing to the system’s insulin suspend features [26]. These results suggest that both rt-CGM and SAP may reduce the burden of hypoglycaemia for PwT1D by allowing for earlier detection of impending hypoglycaemia and a corresponding reduced amount of rescue carbohydrate, when compared to systems without rt-CGM. Lower carbohydrate intake could reduce the risks of rebound hyperglycaemia and weight gain [26]. Moreover, the use of CGM might also influence one’s relationship with food. A qualitative study found that intermittently scanned CGM (is-CGM) use increased self-awareness of food intake, which promoted more flexible eating behaviours for some participants but led others to develop a more restrictive relationship with food [27•]. Conversely, an interventional study found that after 12 weeks of is-CGM use, neither food variety, coefficient of variance (glycemic variability), nor HbA1c changed [28]. While close monitoring of food intake is central in T1D management, it has also been shown to increase the risk of disordered eating behaviours in PwT1D [27•]. A recent systematic review, exploring the use of technology in the context of disordered eating behaviours, found limited inconclusive results, indicating that further research is required to better understand technology use in this context [29].
Postprandial glycaemic fluctuations contribute significantly to the overall glycaemic outcomes; thus, it is imperative to optimize prandial insulin administration [30]. Of the currently available commercial AID systems, CC is still required as current algorithms require meal-announcement with carbohydrate intake to provide appropriate bolus doses. A 3-week non-inferiority trial with 30 adults using AID compared glycaemic outcomes using conventional CC and a simplified qualitative meal-size estimation (based on carbohydrate content). The authors reported significantly higher time in range (TIR, 3.9 to 10.0 mmol/L) with the conventional CC method (74.1 ± 10.0% vs 70.5 ± 11.2%, p = 0.018), lower time above range (TAR > 10.0 mmol/L, 24 ± 10% vs 28 ± 11%, p = 0.014), and similar time below range (TBR, < 3.9 mmol/L) [31]. Although non-inferiority was not achieved, the meal-size estimation arm still had TIR within target (≥ 70%) and low TBR (1.6%) [31]. More recent advances may reduce the need for CC and its related burden. Algorithms such as the recently FDA approved AID device (iLET Bionic Pancreas) only requires a qualitative estimation of carbohydrate content (compared to the usual amount for the user) instead of quantitative CC. In this 13-week RCT, iLet users reported higher TIR (65 ± 9% vs. 54 ± 17%, p < 0.001) and lower TAR (33 ± 9% vs. 44 ± 18%, p < 0.001) compared to standard care (MDI or CSII with rt-CGM, or AID) without a difference in TBR [32••].
While current nutrition guidelines focus on carbohydrate intake, there is established evidence that protein and fat content also influence postprandial glycemia [33]. Earlier studies suggested that CSII offers more flexibility in insulin dose adjustment [34, 35]; however, the more recent advancement in AID has the potential to effectively manage postprandial glycemia, even with varied meal compositions as it can modulate insulin infusion in response to glucose changes [36]. A randomized cross-over study compared the glycaemic response to high fat and/or high protein meals in participants using AID [36]. The study found that high fat and high protein meals resulted in a delayed postprandial glycaemic peak and needed a higher basal rate for 5-h post-meal, compared to the standard meal. Additionally, compared to standard meal (TIR 43 [32–65] %) and high protein meal (54 [27–72] %), high fat meal (38 [23–74] %), and high fat and high protein meal (34 [16–77] %) had the lowest TIR, although statistical significance was not reached [36]. TBR was similar (0%) suggesting that postprandial hyperglycaemia with high fat meals remains challenging even with an AID. Future algorithms should be developed to account for diverse meal compositions [36].
AID systems might also offer additional support to people following special diets (e.g., low carbohydrate diet). A study assessed the association between carbohydrate intake and glycaemic management in 36 AID users by comparing the groups based on percent time spent in auto-mode and their average daily carbohydrate consumption (low (100.9 ± 69.9 g/day) vs medium (171.2 ± 53.4) vs high (222.7 ± 70.6)) [37]. Participants in the low carbohydrate group had higher TIR (77.4 ± 15.4 vs 70.4 ± 17.8, p < 0.001) and lower TAR (20.1 ± 14.7 vs 27.2 ± 18.4, p < 0.001) compared to the high carbohydrate group. The results were especially prominent among AID users who spent more than 90% of the time on auto-mode with higher TIR (82 ± 11.8 vs 73.8 ± 16.3, p < 0.001) and lower TAR (16.2 ± 11.5 vs 24.2, p < 0.001). The TBR was similar between the groups.
These results show significant potential for certain AID algorithms to reduce the burden of prandial insulin administration while maintaining effective glycaemic management. However, there remains a need to further improve these technologies to respond faster to glucose fluctuations (e.g., improved insulin pharmacodynamics and CGM accuracy, more advanced AID algorithm) to potentially reduce the need for CC by users (ACTRN12622001400752).
Digital Platforms
The use of mobile apps to help with CC and bolus estimation for T1D has been increasing due to their convenience, with a variety of mobile apps to choose from. A study surveying adults with diabetes, 1052 of whom live with T1D, found that more than half PwT1D relied on apps for their self-management (such as bolus calculator and carbohydrate intake tracking). Using the Summary of Diabetes Self-Care Activities Questionnaire [38] to measure self-care behaviours, participants who used an app reported improved overall scores, specifically in the general diet subscale and blood glucose monitoring subscale [39]. While current applications continue to rely on input from the user, future technologies integrating artificial intelligence are currently being tested to utilize food image recognition systems to replace manual CC by PwT1D (jRCTs042210167).
Physical Activity
Despite the numerous benefits of engaging in PA, only ~ 30% of PwT1D compared to ~ 50% of individuals without diabetes meet the recommended 150 min of moderate to vigorous PA per week [40, 41]. Specific barriers to PA for PwT1D, notably fear of hypoglycaemia and significant glycaemic variations [42, 43] might be alleviated by technological developments.
Wearable Technologies
Glucose management for PwT1D during PA is easier with CGM [44], and the glycaemic benefits depend on the type of CGM. A study that compared rt-CGM with is-CGM during 4 days with consecutive exercise found the former reduced TBR (6.8 ± 5.5% vs. 11.4 ± 8.6%, p = 0.018) and increased TIR (78.5 ± 10.2% vs. 69.7 ± 16%, p = 0.015) during exercise in 60 adult PwT1D using either MDI or CSII, indicating the extra benefits of alerts [45]. Whether using a CGM contributes to an increase in time spent exercising remains unclear. A prospective national registry in the Netherlands included 1365 participants with diabetes using insulin (1054 PwT1D). The study found that after 1 year of is-CGM use, 37% of participants reported exercising more frequently [46]. However, a sub-analysis of the GOLD randomized trial including 116 adult PwT1D revealed no change in amount of PA, estimated by the International PA Questionnaires (IPAQ) scale [47], between four month rt-CGM and self-monitoring blood glucose, despite improvements in hypoglycemia and fear of hypoglycaemia for CGM group [48]. This may indicate that apart from hypoglycaemia, barriers unrelated to diabetes, including lack of time and motivation, may also hinder PwT1D from PA participation.
The accuracy of CGM tends to decrease during periods of increased activity [49, 50•, 51, 52], due to rapid changes in glycaemia, increased glucose uptake by muscles, and mechanical forces applied to the sensor [49, 50•, 51, 52]. In most cases, however, the decreased accuracy is unlikely to result in a decision that could jeopardize safety [50•, 51]. Considering these data, the use of CGM data to determine insulin dosage and monitor hypoglycaemia trends during exercise can be considered while being interpreted with caution [4].
Compared with CSII + CGM therapy, AID improved overnight and whole day TIR and TAR without increasing TBR, in a small sample size (N = 13) crossover RCT evaluating a 3-day period with daily exercise interventions [53]. Using PA specific AID settings could increase those benefits, especially lowering hypoglycaemia risk. A study which evaluated the TBR during 60 min of aerobic exercise and 1 h after found that TBR was 13.0 ± 19.0% when no strategy was applied, but was reduced to 7.0 ± 12.6% when target glucose was increased 1 h prior to exercise, and was further reduced to 2.0 ± 6.2% when a 33% reduction in meal bolus was applied 1 h prior to exercise in addition to increased target p < 0.0001 and p = 0.005, respectively) [54]. Additionally, two other recent studies demonstrated the glycaemic benefits of pre-exercise strategies with increased TIR and decreased TBR when pre-exercise glucose target was increased and meal bolus was reduced 1–2 h prior to exercise with AID use [55, 56].
While the previously mentioned studies assessed the benefit of strategies applied 1–2 h prior to exercise, new and future technologies are aiming to reduce the need for PwT1D to announce planned activity to AID systems. Adding PA detection from accelerometer or physiological data (e.g., heart rate, skin moisture) could be an effective strategy to improve the performance of AID systems around unannounced PA. Detection systems have been shown to detect the start of PA within 1 min, allowing for prompt insulin reduction before significant glucose decline [57]. During a 3-day inpatient study which included six unannounced exercise sessions including moderate aerobic, high intensity interval, and resistance training, 10 PwT1D using AID with PA detection spent 0.88 ± 2.15% time below 3.0 mmol/L and 1.34 ± 1.55% time between 3.0 and 3.9 mmol/L during and 2 h after the exercise sessions [58]. An alternative approach to improving the performance of AID during activity is based on machine learning of previous exercise habits. A crossover RCT including 15 adults with T1D evaluated the effect of an AID system (APEX) which used artificial intelligence to identify existing exercise behaviours, and prospectively adjust insulin delivery [58]. Compared with a conventional AID system, the APEX system significantly reduced hypoglycaemic episodes during exercise (13 vs. 5) and the 4 h following exercise (11 vs. 2). These innovative systems, driven by artificial intelligence, are providing promising solutions that substantially alleviate glucose management burden during physical activity. Larger sample size studies investigating various exercise types and intensities will be needed to provide confirmatory results.
Another avenue for improving AID with respect to hypoglycaemia prevention around PA is dual-hormone systems, featuring liquid, stable glucagon, to increase blood glucose concentration to maintain target range. Compared to single-hormone AID, a dual-hormone AID system was associated with reduced TBR during and 4 h after unannounced exercise (8.3% [0.0–12.5] vs 0.0% [0.0–4.2], p = 0.025), but was associated with greater TAR (6.3% [0.0, 12.5] vs. 20.8% [0.0–47.9], p = 0.038), respectively [59]. In addition to intra-activity hypoglycaemia, the risk for nocturnal hypoglycaemia is high following PA, mainly due to persisting elevated insulin sensitivity. In a recent pooled analysis involving two available trials comparing dual-hormone to single-hormone AID, 41 adult participants spent 94.0 ± 11.0% and 83.1 ± 20.5% (p < 0.05) in target range and 0 (0, 20.1)% vs 0 (0,0)% (p < 0.001) TBR during the overnight period after exercise, respectively [60•]. Dual-hormone AID may also reduce fear of hypoglycaemia during exercise, although evidence remains scarce [61]. Overall, despite its costs and system complexity, dual-hormone AID warrants more attention regarding both clinical studies and product development, to offer an alternative option for PwT1D who could not attain optimal PA glucose targets or have fear of hypoglycaemia keeping them from PA despite using a single-hormone AID [62].
Digital Platforms
The online T1D and exercise education platform (ExT1D) provided effective training and education for reducing exercise related hypoglycaemic events. Compared to standard treatment, the ExT1D intervention reduced the median frequency and duration of exercise-related hypoglycaemic events by 43% and 52%, respectively [63]. Personalized digital health information such as CGM glucose, physical activity, sleep, and mood can substantiate human delivered exercise support for PwT1D as was shown in a recent study [64]. Specifically, this study of adults with T1D (n = 17) found that after 10 weeks of expert delivered feedback based on personalized data, and other informational and motivation resources (exercise videos, text based coach, self-monitoring diary), physical activity participation increased from a median of 0 to 64 min per week with no severe hypoglycaemia or ketoacidosis events [64].
Smoking Cessation: Tobacco and E-Cigarettes
The estimated global prevalence of current smokers living with T1D ranges between 10 and 30% [65], which is comparable to the general population (17%) [66]. Smoking can increase insulin resistance and is a risk factor for developing microvascular and macrovascular complications, as well as increased glycaemic variability and hypoglycaemia [67, 68]. While smoking abstinence can reduce morbidity and mortality, it can cause significant glycaemic fluctuations as it increases insulin sensitivity and leads to weight fluctuations that can impact glucose management [67, 68].
Wearable technologies such as CGMs might help reduce the unexpected glycaemic variability associated with smoking cessation. However, research is needed to explore their effectiveness in this context. There is currently a growing interest in exploring CGM as a behaviour change tool [69] with some interest to understand how the use of CGM during smoking cessation can provide further perspectives to tailor cessation interventions [70]. Digital platforms can also be used to promote and facilitate smoking cessation. While the current evidence is not specific to T1D, research suggests that technologies such as mobile apps [71] and chatbots [70] can help facilitate smoking cessation in the general population, by offering punctual and personalized support to promote cessation and abstinence [71, 72]. Further research should explore these platforms in T1D as this population has additional diabetes-specific challenges that might not be addressed in the current literature.
Psychosocial Care
The burden of daily decisions related to diabetes management often contributes to depression and mental health challenges related to diabetes. Notably, 42 to 54% of PwT1D experience diabetes distress [73] and the prevalence of major depression is double that of the general population [74]. These challenges can impair PwT1D’s ability to effectively manage T1D and thus compromise glucose outcomes [75]. Current technologies can help implement effective psychosocial care.
Wearable Technologies
Overall, the impact of CGM use on psychosocial aspects in adult PwT1D is positive. A post hoc analysis of a prospective study suggested that the rate of depressive disorder decreased after initiation of is-CGM for 12 months in 527 adult PwT1D [75]. Their mental well-being also improved with a significant increase in the Mental Component Score. Furthermore, a prospective observational multicentre study found a higher Diabetes Treatment Satisfaction Questionnaire score (28.0 [95% CI 26.1; 29.9] vs. 30.4 [28.9; 32.6]; p < 0.0001) in 1913 adults with T1D after 12-month use of is-CGM, compared with baseline (without CGM) [76]. The other quality of life scales (Health Survey questionnaire, Problem Areas in Diabetes, Hypoglycemia Fear Survey –Worry) remained unchanged, possibly due to the already high quality of life at baseline. The same group further investigated the impact of rt-CGM in a 24-month prospective observational study including 441 adult PwT1D using CSII [77]. Improvement in general quality of life, diabetes-related emotional distress, and fear of hypoglycaemia were observed at month 12 and sustained throughout the 24-month follow-up, particularly in those with impaired awareness of hypoglycaemia. While most studies suggest positive impact of CGM use, it is worth noting that a cross-sectional study including 274 adults with T1D found that is- and rt-CGM users, compared to non-CGM users, reported more diabetes-related anxiety and emotional burden, possibly due to pain and skin reactions related to CGM, despite the beneficial effect on glycaemic management and fear of hypoglycaemia [78].
Alongside CGM, AID systems help reduce some psychosocial burdens. AID reduced fear of hypoglycaemia [79,80,81,82,83] and increased overall emotional well-being [84,85,86,87] compared with either CGM + CSII or MDI, among adults with T1D. Improvement in diabetes-related distress was observed in three prospective studies [82, 88, 89••], while two other retrospective observational studies revealed no change [83, 86]. Whether AID use is associated with improved sleep quality is controversial: three studies of older adults with T1D [88, 90, 91] suggested no difference in Pittsburgh Sleep Quality Index score between AID and SAP treatment. An Australian RCT [91] comparing AID and SAP suggested a poorer sleep quality, assessed by daily diary sleep quality ratings, with AID treatment, possibly due to the more frequent alarms during AID intervention. On the other hand, two studies, including one in older adults, reported improved sleep quality [79, 81, 82]. Moreover, a large sample prospective study (N = 1435) suggested that continued use of AID resulted in a reduction in the overall impact of diabetes on participants’ lives and an improvement in device-related satisfaction [84].
Digital Platforms
Telemedicine and virtual group appointments can also play a positive role in maintaining well-being. After four visits over 12 months, two studies found that telehealth visits followed by virtual group appointments, compared to in-person medical visits and telehealth visits only, resulted in significant improvement in diabetes distress, self-efficacy, and the ability to talk about their illness [92, 93]. Neither study revealed a difference in depressive symptoms, quality of life, or self-confidence for any of the groups [92, 93].
A study investigating the impact of ten 50-min psychological therapy sessions via real-time texting over 3 months observed a significant decrease in HbA1c and anxiety, but no change in diabetes distress or depressive symptoms among 71 adults with T1D [94•]. Furthermore, a parallel RCT investigated sleep quality, diabetes distress, and glycaemic management in 14 adult PwT1D [95]. The 8-week study had two parallel arms: Sleep-Opt-In with weekly digital lessons related to sleep, phone calls with a trained sleep coach, and sleep tracking vs. the Healthy Living Attention arm with weekly general health emails and phone calls with a healthy living coach. After 8 weeks, the Sleep-Opt-In group showed an improvement in sleep regularity, daytime sleepiness, and general fatigue, while these worsened in the other group. They also had lower diabetes distress and fewer depressive symptoms [95]. Though no RCTs have evaluated the combination of both telemedicine and wearable technology yet, an upcoming RCT will evaluate the use of a telemedicine-delivered cognitive behavioural therapy program alongside the use of CGM, compared to the use of CGM only, in young adults with T1D living with anxiety and depression (NCT05734313).
In summary, there are an emerging number of original articles on technology use and its impact on psychosocial care in the adult population with T1D [96, 97]. Collectively, they highlight that the use of technology is often associated with improved well-being, reduced fear of hypoglycaemia, and reduced depressive symptoms. Research with larger sample sizes in PwT1D is needed, as most existing literature combines T1D and T2D populations, who may not share the same level of psychosocial burdens. Furthermore, several studies group adolescents and adults together. Future studies investigating the impact of technology or telehealth integration on psychosocial care into an individuals’ treatment plan during different life stages are necessary.
Conclusions
Maintaining positive health behaviours facilitate better health outcomes (glucose and well-being) for PwT1D. However, enforcing these behaviours may also lead to burdens and challenges (e.g., intensive DSME/S may cause psychosocial burden, physical activity can lead to higher risks for hypoglycemia) which impede the realization of such health goals. Advanced diabetes technologies including CGM, AID, and digital platforms alleviate some management burden and allow for more informed decisions (Fig. 1). Nevertheless, reaching optimal glycaemic and psychological outcomes in PwT1D remains challenging, even for those with access to these technologies [4, 5, 9]. Research investigating why this state persists is scarce, and therefore, implementation research studying how to translate benefits of technologies in real-life conditions warrants more attention.
Current diabetes technologies are mostly designed around insulin delivery. Considering the complexity of T1D (e.g., large intra- and interpersonal variation), pharmacotherapy may remain insufficient to achieve optimal diabetes outcomes. Positive health behaviours and well-being interventions provide huge opportunities to supplement T1D treatment [4, 98]. Technologies designed around these interventions should be encouraged and their integration with current AID systems should be a future focus of development.
Uptake of technologies does not guarantee high user engagement. Yet the benefits of technology use usually depend on the level of engagement and adherence [4]. Those having difficulty devoting time and adhering are, in most cases, also individuals prone for suboptimal health outcomes and to whom technologies can offer the most benefits. A balance between device complexity and functionality should be achieved to ensure PwT1D can obtain benefits without being overwhelming. Relevant studies should not only assess glucose outcomes, but patient-reported outcomes and patient-reported experience, to facilitate understanding of both health benefits and users’ experience and burden [99]. These studies will provide crucial information on engagement and adherence (including accessibility, usage, cost, and training), which is key to the successful implementation of these technologies. Practical barriers faced by healthcare professionals should also be assessed to provide a more rounded understanding.
Education and support play a major role [100]. Apart from comprehensive training at initiation, consistent training as well as routine clinical re-assessment of technology use should be implemented to sustain the benefits of technology, and to identify those who would benefit from alternative options. Policy-makers need to encourage opportunities for consistent diabetes education and support, by ensuring proper policies are in place to better support the integration of diabetes education in clinical practice, to both PwT1D and healthcare professionals.
Recommendations for digital platforms in managing T1D remains difficult, mainly due to the lack of high-level evidence and validations of such platforms by regulators. Cost-effectiveness studies are rare, yet will facilitate future uptake and health coverage of these digital platforms, especially mobile applications.
In summary, technologies possess the potential to promote health behaviours changes and well-being for PwT1D, and therefore facilitate the realization of favorable health outcomes. A few ongoing studies are summarized in Table 1. More confirmative studies elucidating the effectiveness and safety of these technologies in a broad and diverse population, along with implementation and cost-effectiveness studies, are urgently needed to ensure optimal integration of technologies in standard care practices. Collaborative engagement involving researchers, healthcare professionals, PwT1D, industry, and government remains vital and should be encouraged to accelerate this process.
Data Availability
All data generated or analyzed during this study are included in this published article [and its supplementary information files].
References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Gregory GA, Robinson TIG, Linklater SE, Wang F, Colagiuri S, de Beaufort C, et al. Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study. Lancet Diabetes Endocrinol. 2022;10(10):741–60.
Nathan DM. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: overview. Diabetes Care. 2014;37(1):9–16.
Holt RIG, DeVries JH, Hess-Fischl A, Hirsch IB, Kirkman MS, Klupa T, et al. The management of type 1 diabetes in adults A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) Diabetes Care. 2021;44(11):2589–625
American Diabetes Association. Standards of medical care in diabetes-2023. Diabetes Care. 2023;46(Suppl 1):S1-291.
Brazeau AS, Messier V, Talbo MK, Gagnon C, Taleb N, Fortier I, et al. Self-reported severe and nonsevere hypoglycemia in type 1 diabetes: population surveillance through the BETTER Patient Engagement Registry: development and baseline characteristics. Can J Diabetes. 2022;46(8):813–21.
Wu ZK, Jin TR, Weng JP. A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope. Sci China Life Sci. 2019;62(1):46–62.
Miller KM, Hermann J, Foster N, Hofer SE, Rickels MR, Danne T, et al. Longitudinal changes in continuous glucose monitoring use among individuals with type 1 diabetes: international comparison in the German and Austrian DPV and U.S. T1D Exchange Registries. Diabetes Care. 2020;43(1):e1-e2
Beck RW, Bergenstal RM, Laffel LM, Pickup JC. Advances in technology for management of type 1 diabetes. Lancet. 2019;394(10205):1265–73.
Nc F, Rw B, Km M, Ma C, Mr R, La D, et al. State of type 1 diabetes management and outcomes from the T1D Exchange in 2016–2018. Diabetes Technol Ther. 2019;21(2):66–72.
Ling P, Yan J, Yang D, Luo S, Zheng X, Wu Z, et al. Current state of type 1 diabetes in China: an analysis from a mobile health application TangTangQuan based database. Diabetologia. 2019;62:S394-S
Garg SK. Past, present, and future of continuous glucose monitors. Diabetes Technol Ther. 2023;25(S3):S1–4. https://doi.org/10.1089/dia.2023.0041.
Bergenstal RM, Tamborlane WV, Ahmann A, Buse JB, Dailey G, Davis SN, et al. Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes. N Engl J Med. 2010;363(4):311–20.
Braune K, Lal RA, Petruzelkova L, Scheiner G, Winterdijk P, Schmidt S, et al. Open-source automated insulin delivery: international consensus statement and practical guidance for health-care professionals. Lancet Diabetes Endocrinol. 2022;10(1):58–74.
Powers MA, Bardsley J, Cypress M, Duker P, Funnell MM, Fischl AH, et al. Diabetes self-management education and support in type 2 diabetes: a joint position statement of the American Diabetes Association, the American Association of Diabetes Educators, and the Academy of Nutrition and Dietetics. J Acad Nutr Diet. 2015;115(8):1323–34.
Rankin D, Cooke DD, Elliott J, Heller SR, Lawton J, the UKNDSG. Supporting self-management after attending a structured education programme: a qualitative longitudinal investigation of type 1 diabetes patients’ experiences and views. BMC Public Health. 2012;12(1):652.
Winkley K, Evwierhoma C, Amiel SA, Lempp HK, Ismail K, Forbes A. Patient explanations for non-attendance at structured diabetes education sessions for newly diagnosed Type 2 diabetes: a qualitative study. Diabet Med. 2015;32(1):120–8.
•• Liu Z, Wang C, Yang D, Luo S, Ding Y, Xu W, et al. High engagement in mobile peer support is associated with better glycemic control in type 1 diabetes: a real-world study. J Diabetes Investig. 2022;13(11):1914–24. A large sample study suggesting that 12 months’ use of a mobile application improved glucose management, especially among those more engaged in peer support
Xie LF, Roy-Fleming A, Haag S, Costa DD, Brazeau AS. Development of the support self-guided, web application for adults living with type 1 diabetes in Canada by a multi-disciplinary team using a people-oriented approach based on the Behaviour Change Wheel. Digit Health. 2023;9:20552076231152760.
Xie L. Design, evaluation, optimization, and adaptation of a web application for type 1 diabetes self-management. https://escholarship.mcgill.ca/concern/theses/j67319489. Accessed 23 Aug 2023.
Lane W, Lambert E, George J, Rathor N, Thalange N. Exploring the burden of mealtime insulin dosing in adults and children with type 1 diabetes. Clin Diabetes. 2021;39(4):347–57.
Evert AB, Dennison M, Gardner CD, Garvey WT, Lau KHK, MacLeod J, et al. Nutrition therapy for adults with diabetes or prediabetes: a consensus report. Diabetes Care. 2019;42(5):731–54.
ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, et al. 5 Facilitating positive health behaviors and well-being to improve health outcomes: standards of care in diabetes-2023. Diabetes Care. 2023;46(Supple 1):S68-s96.
Yale JF, Paty B, Senior PA. Hypoglycemia. Can J Diabetes. 2018;42(Suppl 1):S104–8.
American Diabetes Association. 7. Diabetes technology: standards of medical care in diabetes—2021. Diabetes Care. 2020;44(Supplement_1):S85-S99
•• Waldenmaier D, Freckmann G, Pleus S, Hermanns N, Ehrmann D, Heinemann L, et al. Therapy adjustments in people with type 1 diabetes with impaired hypoglycemia awareness on multiple daily injections using real-time continuous glucose monitoring: a mechanistic analysis of the HypoDE study. BMJ Open Diabetes Res Care. 2021;9(1). First large RCT showing additional possible benefit of rt-CGM to intercept an upcoming hypoglycaemia while reducing the amount of simple carbohydrate needed.
Pinsker JE, Bartee A, Katz M, Lalonde A, Jones R, Dassau E, et al. Predictive low-glucose suspend necessitates less carbohydrate supplementation to rescue hypoglycemia: need to revisit current hypoglycemia treatment guidelines. Diabetes Technol Ther. 2021;23(7):512–6.
• Wallace T, Heath J, Koebbel C. The impact of flash glucose monitoring on adults with type 1 diabetes’ eating habits and relationship with food. Diabetes Res Clin Pract. 2023;196:110230. A novel qualitative study exploring the impact of isCGM on people with type 1 diabetes’ relationship with food.
Ida S, Kaneko R, Imataka K, Okubo K, Shirakura Y, Azuma K, et al. Effects of flash glucose monitoring on dietary variety, physical activity, and self-care behaviors in patients with diabetes. J Diabetes Res. 2020;2020:9463648.
Priesterroth L, Grammes J, Clauter M, Kubiak T. Diabetes technologies in people with type 1 diabetes mellitus and disordered eating: a systematic review on continuous subcutaneous insulin infusion, continuous glucose monitoring and automated insulin delivery. Diabet Med. 2021;38(7):e14581.
Ketema EB, Kibret KT. Correlation of fasting and postprandial plasma glucose with HbA1c in assessing glycemic control; systematic review and meta-analysis. Arch Public Health. 2015;73:43.
Haidar A, Legault L, Raffray M, Gouchie-Provencher N, Jafar A, Devaux M, et al. A randomized crossover trial to compare automated insulin delivery (the artificial pancreas) with carbohydrate counting or simplified qualitative meal-size estimation in type 1 diabetes. Diabetes Care. 2023;46(7):1372–8.
•• Russell SJ, Beck RW, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro CA, et al. Multicenter, randomized trial of a bionic pancreas in type 1 diabetes. N Engl J Med. 2022;387(13):1161–72. Large RCT assessing a novel technology (bionic pancreas) requiring minimal input from the user
Al Balwi R, Al Madani W, Al GA. Efficacy of insulin dosing algorithms for high-fat high-protein mixed meals to control postprandial glycemic excursions in people living with type 1 diabetes: A systematic review and meta-analysis. Pediatr Diabetes. 2022;23(8):1635–46.
Metwally M, Cheung TO, Smith R, Bell KJ. Insulin pump dosing strategies for meals varying in fat, protein or glycaemic index or grazing-style meals in type 1 diabetes: a systematic review. Diabetes Res Clin Pract. 2021;172:108516.
McKnight JA, Ochs A, Mair C, McKnight O, Wright R, Gibb FW, et al. The effect of DAFNE education, continuous subcutaneous insulin infusion, or both in a population with type 1 diabetes in Scotland. Diabet Med. 2020;37(6):1016–22.
Gingras V, Bonato L, Messier V, Roy-Fleming A, Smaoui MR, Ladouceur M, et al. Impact of macronutrient content of meals on postprandial glucose control in the context of closed-loop insulin delivery: a randomized cross-over study. Diabetes Obes Metab. 2018;20(11):2695–9.
Lehmann V, Zueger T, Zeder A, Scott S, Bally L, Laimer M, et al. Lower daily carbohydrate intake is associated with improved glycemic control in adults with type 1 diabetes using a hybrid closed-loop system. Diabetes Care. 2020;43(12):3102–5.
Toobert DJ, Hampson SE, Glasgow RE. The summary of diabetes self-care activities measure: results from 7 studies and a revised scale. Diabetes Care. 2000;23(7):943–50.
Kebede MM, Pischke CR. Popular diabetes apps and the impact of diabetes app use on self-care behaviour: a survey among the digital community of persons with diabetes on social media. Front Endocrinol (Lausanne). 2019;10:135.
Bohn B, Herbst A, Pfeifer M, Krakow D, Zimny S, Kopp F, et al. Impact of physical activity on glycemic control and prevalence of cardiovascular risk factors in adults with type 1 diabetes: a cross-sectional multicenter study of 18,028 patients. Diabetes Care. 2015;38(8):1536–43.
Center for Surveillance and Applied Research, Public Health Agency of Canada. Physical Activity, Sedentary Behaviour and Sleep (PASS) indicators, 2023 Edition. 2023. https://health-infobase.canada.ca/pass/. Accessed 30th Aug 2023.
Brazeau AS, Rabasa-Lhoret R, Strychar I, Mircescu H. Barriers to physical activity among patients with type 1 diabetes. Diabetes Care. 2008;31(11):2108–9.
Parent C, Lespagnol E, Berthoin S, Tagougui S, Heyman J, Stuckens C, et al. Barriers to physical activity in children and adults living with type 1 diabetes: a complex link with real-life glycemic excursions. Can J Diabetes. 2023;47(2):124–32.
Moser O, Riddell MC, Eckstein ML, Adolfsson P, Rabasa-Lhoret R, van den Boom L, et al. Glucose management for exercise using continuous glucose monitoring (CGM) and intermittently scanned CGM (isCGM) systems in type 1 diabetes: position statement of the European Association for the Study of Diabetes (EASD) and of the International Society for Pediatric and Adolescent Diabetes (ISPAD) endorsed by JDRF and supported by the American Diabetes Association (ADA). Diabetologia. 2020;63(12):2501–20.
Hásková A, Radovnická L, Petruželková L, Parkin CG, Grunberger G, Horová E, et al. Real-time CGM is superior to flash glucose monitoring for glucose control in type 1 diabetes: the CORRIDA randomized controlled trial. Diabetes Care. 2020;43(11):2744–50.
Marion F, van Peter D, Mireille E, Eglantine B, Jeanine M, Robbert S, et al. Improved well-being and decreased disease burden after 1-year use of flash glucose monitoring (FLARE-NL4). BMJ Open Diabetes Res Care. 2019;7(1):e000809.
Mannocci A, Masala D, Mei D, Tribuzio AM, Villari P, LA Torre G. International physical activity questionnaire for adolescents (IPAQA): reliability of an Italian version. Minerva Pediatr (Torino). 2021;73(5):383–390. https://doi.org/10.23736/S2724-5276.16.04727-7.
Nystrom T, Schwarz E, Dahlqvist S, Wijkman M, Ekelund M, Holmer H, et al. Evaluation of effects of continuous glucose monitoring on physical activity habits and blood lipid levels in persons with type 1 diabetes managed with MDI: an analysis based on the GOLD randomized trial (GOLD 8). J Diabetes Sci Technol. 2022:19322968221101916
Biagi L, Bertachi A, Quirós C, Giménez M, Conget I, Bondia J, Vehí J. Accuracy of continuous glucose monitoring before, during, and after aerobic and anaerobic exercise in patients with type 1 diabetes mellitus. Biosensors (Basel). 2018;8(1):22. https://doi.org/10.3390/bios8010022.
• Da Prato G, Pasquini S, Rinaldi E, Lucianer T, Donà S, Santi L, et al. Accuracy of CGM systems during continuous and interval exercise in adults with type 1 diabetes. J Diabetes Sci Technol. 2022;16(6):1436–43. Prospective study suggesting concerning findings that commercially available systems showed lower accuracy than claimed during inpatient exercise testing, especially for continuous exercise.
Fokkert M, van Dijk PR, Edens MA, Díez Hernández A, Slingerland R, Gans R, Delgado Álvarez E, Bilo H. Performance of the Eversense versus the Free-Style Libre Flash glucose monitor during exercise and normal daily activities in subjects with type 1 diabetes mellitus. BMJ Open Diabetes Res Care. 2020;8(1):e001193. https://doi.org/10.1136/bmjdrc-2020-001193.
Fokkert MJ, van Dijk PR, Edens MA, Díez A, Slingerland RJ, Gans ROB, et al. Performance of continuous glucose monitoring devices during intensive exercise conditions in people with diabetes: the Mont Blanc experience. Diabet Med. 2020;37(7):1204–5.
Hanaire H, Franc S, Borot S, Penfornis A, Benhamou P-Y, Schaepelynck P, et al. Efficacy of the Diabeloop closed-loop system to improve glycaemic control in patients with type 1 diabetes exposed to gastronomic dinners or to sustained physical exercise. Diabetes Obes Metab. 2020;22(3):324–34.
Tagougui S, Taleb N, Legault L, Suppere C, Messier V, Boukabous I, et al. A single-blind, randomised, crossover study to reduce hypoglycaemia risk during postprandial exercise with closed-loop insulin delivery in adults with type 1 diabetes: announced (with or without bolus reduction) vs unannounced exercise strategies. Diabetologia. 2020;63(11):2282–91.
Paldus B, Morrison D, Zaharieva DP, Lee MH, Jones H, Obeyesekere V, et al. A randomized crossover trial comparing glucose control during moderate-intensity, high-intensity, and resistance exercise with hybrid closed-loop insulin delivery while profiling potential additional signals in adults with type 1 diabetes. Diabetes Care. 2022;45(1):194–203.
Myette-Cote E, Molveau J, Wu Z, Raffray M, Devaux M, Tagougui S, et al. A randomized crossover pilot study evaluating glucose control during exercise initiated 1 or 2 h after a meal in adults with type 1 diabetes treated with an automated insulin delivery system. Diabetes Technol Ther. 2023;25(2):122–30.
Cho S, Aiello EM, Ozaslan B, Riddell MC, Calhoun P, Gal RL, Doyle FJ 3rd. Design of a real-time physical activity detection and classification framework for individuals with type 1 diabetes. J Diabetes Sci Technol. 2023;17:19322968231153896. https://doi.org/10.1177/19322968231153896.
Turksoy K, Hajizadeh I, Hobbs N, Kilkus J, Littlejohn E, Samadi S, et al. Multivariable artificial pancreas for various exercise types and intensities. Diabetes Technol Ther. 2018;20(10):662–71.
Wilson LM, Jacobs PG, Ramsey KL, Resalat N, Reddy R, Branigan D, et al. Dual-hormone closed-loop system using a liquid stable glucagon formulation versus insulin-only closed-loop system compared with a predictive low glucose suspend system: an open-label, outpatient, single-center, crossover, randomized controlled trial. Diabetes Care. 2020;43(11):2721–9.
• Wu Z, Yardley JE, Messier V, Legault L, Grou C, Rabasa-Lhoret R. Comparison of nocturnal glucose after exercise among dual-hormone, single-hormone algorithm-assisted insulin delivery system and usual care in adults and adolescents living with type 1 diabetes: a pooled analysis. Diabetes Technol Ther. 2022;24(10):754–62. Pooled analysis including all available studies suggesting that dual-hormone automated insulin delivery (AID) systems allow improved postexercise nocturnal glycaemic management than single-hormone AID or usual care among adults with type 1 diabetes.
Taleb N, Quintal A, Rakheja R, Messier V, Legault L, Racine E, et al. Perceptions and expectations of adults with type 1 diabetes for the use of artificial pancreas systems with and without glucagon addition: results of an online survey. Nutr Metab Cardiovasc Dis. 2021;31(2):658–65.
Wu Z, Lebbar M, Taleb N, Legault L, Messier V, Rabasa-Lhoret R. Comparing dual-hormone and single-hormone automated insulin delivery systems on nocturnal glucose management among children and adolescents with type 1 diabetes: a pooled analysis. Diabetes, Obes Metab. 2022;25(1):310–3.
Piotrowicz AK, McGill MJ, Overland J, Molyneaux L, Johnson NA, Twigg SM. An on-line support tool to reduce exercise-related hypoglycaemia and improve confidence to exercise in type 1 diabetes. J Diabetes Complications. 2019;33(9):682–9.
Ash GI, Nally LM, Stults-Kolehmainen M, De Los Santos M, Jeon S, Brandt C, Gulanski BI, Spanakis EK, Baker JS, Weinzimer SA, Fucito LM. Personalized digital health information to substantiate human-delivered exercise support for adults with type 1 diabetes. Clin J Sport Med. 2023;33(5):512–20. https://doi.org/10.1097/JSM.0000000000001078.
Durlach V, Vergès B, Al-Salameh A, Bahougne T, Benzerouk F, Berlin I, et al. Smoking and diabetes interplay: a comprehensive review and joint statement. Diabetes Metab. 2022;48(6):101370.
World Health Organization. WHO global report on trends in prevalence of tobacco use 2000-2025, 4th edn. Geneva: World Health Organization; 2021.
Campagna D, Alamo A, Di Pino A, Russo C, Calogero AE, Purrello F, et al. Smoking and diabetes: dangerous liaisons and confusing relationships. Diabetol Metab Syndr. 2019;11(1):85.
Jensen MH, Cichosz SL, Hirsch IB, Vestergaard P, Hejlesen O, Seto E. Smoking is associated with increased risk of not achieving glycemic target, increased glycemic variability, and increased risk of hypoglycemia for people with type 1 diabetes. J Diabetes Sci Technol. 2021;15(4):827–32.
Ehrhardt N, Al ZE. Continuous glucose monitoring as a behavior modification tool. Clin Diabetes. 2020;38(2):126–31.
Nail K, Martinez S, Terry R, Ice S, Keener S, Ritter T, Nolan D. Feasibility of using biomarkers to examine associations between commercial cigarette smoking and glycemic levels during a smoking cessation attempt. In: Poster presented at Research Week. Tulsa, OH: Oklahoma State University Center for Health Sciences; 2023.
Barroso-Hurtado M, Suárez-Castro D, Martínez-Vispo C, Becoña E, López-Durán A. Smoking cessation apps: a systematic review of format, outcomes, and features. Int J Environ Res Public Health. 2021;18(21):11664. https://doi.org/10.3390/ijerph182111664.
Olano-Espinosa E, Avila-Tomas JF, Minue-Lorenzo C, Matilla-Pardo B, Serrano ME, Martinez-Suberviola FJ, et al. Effectiveness of a conversational chatbot (Dejal@bot) for the adult population to quit smoking: pragmatic, multicenter, controlled, randomized clinical trial in primary care. JMIR Mhealth Uhealth. 2022;10(6):e34273.
Fisher L, Hessler D, Polonsky W, Strycker L, Masharani U, Peters A. Diabetes distress in adults with type 1 diabetes: prevalence, incidence and change over time. J Diabetes Complications. 2016;30(6):1123–8.
Trief PM, Xing D, Foster NC, Maahs DM, Kittelsrud JM, Olson BA, et al. Depression in adults in the T1D Exchange Clinic Registry. Diabetes Care. 2014;37(6):1563–72.
Bakker JJ, Lameijer A, Flores Guerrero JL, Bilo HJG, van Dijk PR. Commencement of flash glucose monitoring is associated with a decreased rate of depressive disorders among persons with diabetes (FLARE-NL7). BMJ Open Diabetes Res Care. 2022;10(3):e002769. https://doi.org/10.1136/bmjdrc-2022-002769.
Charleer S, De Block C, Van Huffel L, Broos B, Fieuws S, Nobels F, et al. Quality of life and glucose control after 1 year of nationwide reimbursement of intermittently scanned continuous glucose monitoring in adults living with type 1 diabetes (FUTURE): a prospective observational real-world cohort study. Diabetes Care. 2019;43(2):dc191610.
Charleer S, De Block C, Nobels F, Radermecker RP, Lowyck I, Mullens A, Scarnière D, Spincemaille K, Strivay M, Weber E, Taes Y, Vercammen C, Keymeulen B, Mathieu C, Gillard P; RESCUE Trial Investigators. Sustained impact of real-time continuous glucose monitoring in adults with type 1 diabetes on insulin pump therapy: results after the 24-month RESCUE study. Diabetes Care. 2020;43(12):3016–23. https://doi.org/10.2337/dc20-1531.
Lukacs A, Szerencsi LB, Barkai L. Continuous glucose monitoring (CGM) satisfaction and its effect on mental health and glycemic control in adults with type 1 diabetes. Physiol Int. 2022;109(4):501–10.
Beato-Vibora PI, Gallego-Gamero F, Ambrojo-Lopez A, Gil-Poch E, Martin-Romo I, Arroyo-Diez FJ. Amelioration of user experiences and glycaemic outcomes with an Advanced Hybrid Closed Loop System in a real-world clinical setting. Diabetes Res Clin Pract. 2021;178:108986.
Boscari F, Ferretto S, Cavallin F, Bruttomesso D. Switching from predictive low glucose suspend to advanced hybrid closed loop control: effects on glucose control and patient reported outcomes. Diabetes Res Clin Pract. 2022;185:109784.
Kubilay E, Trawley S, Ward GM, Fourlanos S, Grills CA, Lee MH, et al. Lived experience of older adults with type 1 diabetes using closed-loop automated insulin delivery in a randomised trial. Diabet Med. 2023;40(4):e15020.
Wong JJ, Hood KK, Hanes SJ, Lal RA, Naranjo D. Psychosocial effects of the loop open-source automated insulin delivery system. J Diabetes Sci Technol. 2023;17(6):1440–7. https://doi.org/10.1177/19322968221105288.
Wu Z, Luo S, Zheng X, Bi Y, Xu W, Yan J, et al. Use of a do-it-yourself artificial pancreas system is associated with better glucose management and higher quality of life among adults with type 1 diabetes. Ther Adv Endocrinol Metab. 2020;11:2042018820950146.
Pinsker JE, Müller L, Constantin A, Leas S, Manning M, McElwee Malloy M, et al. Real-world patient-reported outcomes and glycemic results with initiation of control-IQ technology. Diabetes Technol Ther. 2021;23(2):120–7.
Matejko B, Juza A, Kieć-Wilk B, Cyranka K, Krzyżowska S, Chen X, et al. Transitioning of people with type 1 diabetes from multiple daily injections and self-monitoring of blood glucose directly to MiniMed 780G advanced hybrid closed-loop system: a two-center, randomized, controlled study. Diabetes Care. 2022;45(11):2628–35.
Patel R, Crabtree TSJ, Taylor N, Langeland L, Gazis AT, Mendis B, Wilmot EG, Idris I. Safety and effectiveness of do-it-yourself artificial pancreas system compared with continuous subcutaneous insulin infusions in combination with freestyle libre in people with type 1 diabetes. Diabet Med. 2022;39(5):e14793. https://doi.org/10.1111/dme.14793.
Cyranka K, Matejko B, Juza A, Kieć-Wilk B, Krzyżowska S, Cohen O, et al. Improvement of selected psychological parameters and quality of life of patients with type 1 diabetes mellitus undergoing transition from multiple daily injections and self-monitoring of blood glucose directly to the MiniMed 780G advanced hybrid closed-loop system: post hoc analysis of a randomized control study. JMIR Form Res. 2023;7:e43535.
Bisio A, Gonder-Frederick L, McFadden R, Chernavvsky D, Voelmle M, Pajewski M, et al. The impact of a recently approved automated insulin delivery system on glycemic, sleep, and psychosocial outcomes in older adults with type 1 diabetes: a pilot study. J Diabetes Sci Technol. 2022;16(3):663–9.
•• Polonsky WH, Hood KK, Levy CJ, MacLeish SA, Hirsch IB, Brown SA, et al. How introduction of automated insulin delivery systems may influence psychosocial outcomes in adults with type 1 diabetes: findings from the first investigation with the Omnipod R 5 System. Diabetes Res Clin Pract. 2022;190:109998. Large sample study suggesting that using an automated insulin delivery system for 3 months significantly improved confidence in hypoglycaemia management and diabetes distress.
Thabit H, Boughton C, Mubita W, Rubio J, Mader JK, Narendran P, et al. Impact of the CamAPS FX hybrid closed-loop insulin delivery system on sleep traits in older adults with type 1 diabetes. Diabetes Obes Metab. 2023;25(3):889–93.
Chakrabarti A, Trawley S, Kubilay E, Mohammad Alipoor A, Vogrin S, Fourlanos S, et al. Closed-loop insulin delivery effects on glycemia during sleep and sleep quality in older adults with type 1 diabetes: results from the ORACL trial. Diabetes Technol Ther. 2022;24(9):666–71.
Bisno DI, Reid MW, Fogel JL, Pyatak EA, Majidi S, Raymond JK. Virtual group appointments reduce distress and improve care management in young adults with type 1 diabetes. J Diabetes Sci Technol. 2022;16(6):1419–27.
Bakhach M, Reid MW, Pyatak EA, Berget C, Cain C, Thomas J, et al. Home telemedicine (CoYoT1 Clinic): a novel approach to improve psychosocial outcomes in young adults with diabetes. Diabetes Educ. 2019;45(4):420–30.
• Doherty AM, Herrmann-Werner A, Rowe A, Brown J, Weich S, Ismail K. Feasibility study of real-time online text-based CBT to support self-management for people with type 1 diabetes: the Diabetes On-line Therapy (DOT) Study. BMJ Open Diabetes Res. 2021;9(1):01. The only recent study investigated that integrating online text–based therapy into the treatment plan of adults with T1D improved glycaemic management and anxiety.
Martyn-Nemeth P, Duffecy J, Quinn L, Steffen A, Baron K, Chapagai S, et al. Sleep-opt-in: a randomized controlled pilot study to improve sleep and glycemic variability in adults with type 1 diabetes. Sci Diabetes Self Manag Care. 2023;49(1):11–22.
Talbo MK, Katz A, Peters T, Yale J-F, Wu Z, Brazeau A-S. 660-P: the effect of real-time continuous glucose monitors on fear of hypoglycemia in people with type 1 diabetes: a systematic review and meta-analysis. Diabetes. 2022;71(Supplement_1):660–P. https://doi.org/10.2337/db22-660-P.
Talbo MK, Katz A, Hill L, Peters TM, Yale JF, Brazeau AS. Effect of diabetes technologies on the fear of hypoglycaemia among people living with type 1 diabetes: a systematic review and meta-analysis. EClinicalMedicine. 2023;62:102119.
Chinese Diabetes Society, Chinese Endocrinologist Association, Chinese Society of Endocrinology, Chinese Pediatric Society. Guidelines for the diagnosis and treatment of type 1 diabetes mellitus in China (2021 edition). Chin J Diabetes Mellitus. 2022;14(11):1143–250.
Wu Z, Bandini A, Brazeau AS, Rabasa-Lhoret R. Patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs), it’s time to give more credits to patients’ voice in research: the example of assessing hypoglycemia burden. Diabetes Metab. 2023;49(2):101417.
Wu Z, Talbo M, Lebbar M, Messier V, Courchesne A, Brazeau AS, et al. Characteristics associated with having a hemoglobin A1c ≤ 7 % (≤53 mmol/mol) among adults with type 1 diabetes using an automated insulin delivery system. Diabetes Res Clin Pract. 2023;206:111006.
Acknowledgements
We would like to thank Dr. Lifeng Xie at McGill University for her contribution in discussion, writing, and reviewing.
Funding
Z. W. is supported by fellowships from Canadian Institutes of Health Research and Fonds de Recherche du Québec—Santé. He also receives grants from the Canadian Institutes of Health Research, Juvenile Diabetes Research Foundation, and Société Francophone du Diabète.
Author information
Authors and Affiliations
Contributions
R.M and M.T are the first authors and Z.W is the corresponding author for the manuscript. All authors contributed to the design and drafting of the paper, reviewed and approved the manuscript for scholarly content.
Corresponding author
Ethics declarations
Competing Interests
The authors declare no competing interests.
Conflict of Interest
All authors declare no conflict of interests.
Human and Animal Rights and Informed Consent.
This article does not contain any studies with human or animal subjects performed by any of the authors.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Reid D. McClure and Meryem K. Talbo are co-first authors.
Supplementary Information
Below is the link to the electronic supplementary material.
11892_2024_1534_MOESM2_ESM.xlsx
Supplementary file2 Supplementary Table 1: Extracted studies from literature search for the categories of DSME/S, medical nutrition, physical activity, and psychosocial care among adults with type 1 diabetes. (XLSX 62 KB)
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
McClure, R.D., Talbo, M.K., Bonhoure, A. et al. Exploring Technology’s Influence on Health Behaviours and Well-being in Type 1 Diabetes: a Review. Curr Diab Rep 24, 61–73 (2024). https://doi.org/10.1007/s11892-024-01534-6
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11892-024-01534-6