Abstract
Ischemic stroke is a serious cerebrovascular disease with high morbidity and mortality. As a result of ischemia-reperfusion, a cascade of pathophysiological responses is triggered by the imbalance in metabolic supply and demand, resulting in cell loss. These cellular injuries follow various molecular mechanisms solely or in combination with this disorder. Mitochondria play a driving role in the pathophysiological processes of ischemic stroke. Once ischemic stroke occurs, damaged cells would respond to such stress through mitophagy. Mitophagy is known as a conservatively selective autophagy, contributing to the removal of excessive protein aggregates and damaged intracellular components, as well as aging mitochondria. Moderate mitophagy may exert neuroprotection against stroke. Several pathways associated with the mitochondrial network collectively contribute to recovering the homeostasis of the neurovascular unit. However, excessive mitophagy would also promote ischemia-reperfusion injury. Therefore, mitophagy is a double-edged sword, which suggests that maximizing the benefits of mitophagy is one of the direction of future efforts. This review emphasized the role of mitophagy in ischemic stroke, and highlighted the crosstalk between mitophagy and apoptosis/necroptosis.
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Author Kun XIONG is a member of the Young Editorial Board for Current Medical Science. The paper was handled by the other editor and has undergone rigorous peer review process. Author Kun XIONG was not involved in the journal’s review of, or decision related to, this manuscript.
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This work was supported by grants from the National Natural Science Foundation of China (No. 81971891, No. 82172196, No. 81772134 and No. 81571939), Key Laboratory of Emergency and Trauma (Hainan Medical University) of Ministry of Education (No. KLET-202108), and the College Students’ Innovation and Entrepreneurship Project (No. S20210026020013).
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Yang, Yd., Li, Zx., Hu, Xm. et al. Insight into Crosstalk Between Mitophagy and Apoptosis/Necroptosis: Mechanisms and Clinical Applications in Ischemic Stroke. CURR MED SCI 42, 237–248 (2022). https://doi.org/10.1007/s11596-022-2579-3
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DOI: https://doi.org/10.1007/s11596-022-2579-3