Abstract
In order to characterize hydroxyapatite (HAP) as a possible carrier of medicinal drugs and radionuclides, the possibility of using HAP modified with zinc ions (HAP-Zn) for the sorption of albumin, in particular, bovine serum albumin (BSA), was considered, using the latter as an intermediate binding protein in complex with a heterocyclic ligand of medical purpose. The kinetics of sorption of albumin correspond to the pseudo-second order, and the parameters of the sorption isotherm can be described using calculations based on the Langmuir theory of monolayer adsorption. The results of experiments on the sequential and joint sorption of a heterocyclic ligand on HAP-Zn in the presence of BSA are ambiguous about the sorption binding of this ligand to the sorbent, however, an interaction (binding) between the starting BSA and the ligand was present.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
B. V. Egorova, O. A. Fedorova, S. N. Kalmykov, Russ. Chem. Rev., 2019, 88, 901.
F. Sun, H. Zhou, J. Lee, Acta Biomaterialia, 2011, 7, 3813; DOI: https://doi.org/10.1016/j.actbio.2011.07.002.
D. W. Hitmacher, J. T. Schantz, C. X. F. Larn, K. C. Tan, T. C. Lim, J. Tissue Eng. Regenerative Med., 2007, 1, 245; DOI: https://doi.org/10.1002/term.24.
M. A. Orlova, A. L. Nikolaev, T. P. Trofimova, A. P. Orlov, A. V. Severin, S. N. Kalmykov, Bull. RSMU (Engl. Transl.), 2018, 6, 86; DOI: https://doi.org/10.24075/vrgmu.2018.075.
M. A. Orlova, A. D. Nikolaev, T. P. Trofimova, A. V. Severin, A. V. Gopin, N. S. Zolotova, V. K. Dolgova, A. P. Orlov, Russ. Chem. Bull., 2019, 68, 1102; DOI: https://doi.org/10.1007/s11172-019-2526-z.
A. Ezerskyte-Miseviciene, I. Bogdanoviciene, A. Zilinskas, A. Beganskiene, A. Kareiva, J. Austral. Cer. Soc., 2020, 56, 839; DOI: https://doi.org/10.1007/s41779-019-00402-x.
M. A. Orlova, T. P. Trofimova, A. P. Orlov, I. A. Ivanov, A. V. Severin, G. Yu. Aleshin, S. S. Belyshev, A. N. Vasil´ev, S. N. Kalmykov, Russ. Chem. Bull., 2018, 67, 774; DOI: https://doi.org/10.1007/s11172-018-2136-1.
M. A. Orlova, T. P. Trofimova, N. S. Zolotova, I. A. Ivanov, V. V. Spiridonov, A. N. Proshin, A. A. Borodkov, A. A. Iaroslavov, A. P. Orlov, Russ. Chem. Bull., 2019, 68, 1933; DOI: https://doi.org/10.1007/s11172-019-2649-2.
A. V. Severin, M. A. Orlova, E. S. Shalamova, T. P. Trofimova, I. A. Ivanov, Russ. Chem. Bull., 2017, 66, 9; DOI: https://doi.org/10.1007/s11172-017-1692-0.
A. V. Severin, G. A. Badun, M. G. Chernysheva, Moscow Univ. Chem. Bull. (Engl. Transi), 2011, 66, 371; DOI: https://doi.org/10.3103/S0027131411060083.
Author information
Authors and Affiliations
Corresponding author
Additional information
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 2014–2018, October, 2021.
This work was financially supported by the Russian Foundation for Basic Research (Project No. 19-08-00055).
This paper does not contain descriptions of studies on animals or humans.
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Shalamova, E.S., Severin, A.V., Trofimova, T.P. et al. Specific features of sorption of bovine serum albumin on hydroxyapatite doped with zinc ions, and the possibilities of its use as an intermediate binding protein for heterocyclic ligands. Russ Chem Bull 70, 2014–2018 (2021). https://doi.org/10.1007/s11172-021-3309-x
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11172-021-3309-x