A sensitive, easy, and low-cost method used in the determination of pure forms of losartan and mebeverine hydrochloride, also in pharmaceutical preparations with derivative spectrometry using UV-Vis technology. This method depends on measuring the first derivative of the spectrum using zero cross, peak to base line, and peak area. The linear range of concentrations used was equal to 2–14 ppm for losartan, whereas for mebeverine hydrochloride it was equal to 2–16 ppm in a mixture. For losartan, in the presence of mebeverine hydrochloride, 12 ppm by utilizing peak to baseline correlation coefficients 0.9984, 0.9994, and peak area 0.9972, whereas for mebeverine hydrochloride in the presence of losartan, 12 ppm by utilizing peak to fundamental correlation coefficients 0.9952, 0.9966, 0.9957, and peak area 0.9970, 0.9971, 0.9968, 0.9971. The limit of detection for each drug, losartan and mebeverine hydrochloride, is equal to 0.0113 ppm. The accuracy and precision of the method were estimated by calculating relative standard deviation (%RSD) values less than 3% while maintaining a recovery percentage of acceptable value. The proposed method proved effective and efficient at estimating both losartan and mebeverine hydrochloride, in the presence of the other in a mixture of the two without interference, despite the closeness of their spectral absorption peaks. There are no other more accurate methods for estimating the two in a mixture than the proposed method. The proposed method is considered one of the most direct and economical methods that do not require reagents or additional materials for conducting reactions and studying the optimal conditions for those interactions. Thus, it is considered one of the green chemistry techniques that reduce the use of chemicals and reagents in the process of estimating these drugs in a mixture and in a shorter period of time. The proposed method can be used to estimate the different properties in a mixture of the two compounds whose absorption spectra are close.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Dobrina Doncheva Tsvetkova, and Stefka Achkova Ivanova, Indo Am. J. Pharm. Sci., 5, No. 8, 1–9 (2018); 10.5281/zenodo.1411659.
Antonella S. Araujo-Fernandez, José C. Uribe-Villarreal, Enma Perez-Chauca, Pedro M. Alva-Plasencia, Olga E. Caballero-Aquiño, and Mayar L. Ganoza-Yupanqui, J. Pharm. Pharm. Res., 10, No. 2, 310–317 (2022), https://doi.org/10.56499/jppres21.1212_10.2.310.
Asmaa Ghanim Dawood and Lazeeza Sattar Omer, Iraqi J. Sci., 61, No. 12, 3141–3153 (2020); https://doi.org/10.24996/ijs.2020.61.12.1.
A. Latif, F. Akbar, A. J. Khan, H. Shafi , and M. Mazhar, Pharm. Anal. Acta, 9, No. 7, 1–6 (2018); https://doi.org/10.4172/2153-2435.1000592.
Ü. Özgür and D. Erdal, Sakarya Univ. J. Sci., 25, No. 6, 1432–1437 (2021); https://doi.org/10.16984/saufenbilder.989654.
D. Nagavalli, V. Vaidhyalingam, A. Santha, A. Sankar, and O. Divya, Acta Pharm., 60, No. 2, 141–152 (2010); https://doi.org/10.2478/v10007-010-0017-8.
T. B. Tran, P. T. Le, V. H. Nguyen, D. G. Nguyen, D. L. Nguyen, and T. Q. Nguyen, J. Anal. Methods Chem., Article ID 2754133, 1–8 (2021), https://doi.org/10.1155/2021/2754133.
Maneesha C. Abeysekera, Muditha B. Herath, Shehani H. Basnagoda, and Udaya K. Jayasundara, System. Rev. Pharm., 13, No. 2, 116–121 (2022); https://doi.org/10.31858/0975-8453.13.2.116-121.
Rudy Bonlio, Lívia Botacini Favoretto, Gislaine Ribeiro Pereira, Roberta de Cássia Pimentel Azevedo, Magali Benjamim de Araújo, Braz. J. Pharm. Sci., 46, No. 1, 147–155 (2010); https://doi.org/10.1590/S1984-82502010000100017.
Rubén M. Maggio, Patricia M. Castellano, and Teodoro S. Kaufman, Anal. Bioanal. Chem., 391, No. 8, 2949–2955 (2008); https://doi.org/10.1007/s00216-008-2180-z.
Nief Rahman Ahmed, Mohammad Jassim Essa, and Muna Sobhi Abdullah, World J. Pharm. Res., 8, No. 11, 89–96 (2019) https://doi.org/10.20959/wjpr201911-15890.
Elham N. Mezaal, Maha A. Mohammed, and Kawther Ahmed Sadi, J. Med. Chem. Sci., 6, No. 5, 1112–1119 (2023); https://doi.org/10.26655/JMCHEMSCI.2023.5.16.
T. P. Aneesh, Renju Radhakrishnan, P. M. Aravind, Anuja Sasidharan, and Manisha Choyal, Int. Res. J. Pharm., 6, No. 7, 453–457 (2015); https://doi.org/10.7897/2230-8407.06793.
Q. Shuhong, L. Kai, M. Panqin, W. Menglin, C. Hongming, X. Xiaochao, H. Xiaoli, and W. Yongjun, Current Pharm. Analysis, 11, No. 1, 25–34 (2015); https://doi.org/10.2174/1573412910999141010152758.
Amna B. W. E. Mohammed, and Elsadig H. Rudwan, Int. J. Pharm. Sci. Res., 7, No. 6, 2343–2351 (2016); https://doi.org/10.13040/IJPSR.0975-8232.7(6).2343-51.
Lisa Foley, Jennifer Toney, James W. Barlow, Maura O'Connor, Deirdre Fitzgerald-Hughes, and Zebunnissa Ramtoola, Molecules, 26, No. 2, 1–9 (2021), https://doi.org/10.3390/molecules26020301.
Shereen Shalan and Jenny Jeehan Nasr, Royal Soc. Open Sci., 6, No. 4, 2–6 (2019); https://doi.org/10.1098/rsos.190310.
S. A. Soad, E. Magda, M. Khaled, and E. I. Adel, Royal Soc. Open Sci., 9, No. 6, 1–10 (2022); https://doi.org/10.1098/rsos.220250.
Tadiboyina Sirisha, Bannimath Gurupadayya, and Sridhar Siddiraju, Adv. Pharm. Bull., 5, No. 1, 133–136 (2015); https://doi.org/10.5681/apb.2015.019.
Priyanka A. Shah, Primal Sharma, Jaivik V. Shah, Mallika Sanyal, and Pranav S. Shrivastav, Turkish J. Chem., 39, 714–733 (2015); https://doi.org/10.3906/kim-1502-4.
X. L. Jun, H. M. Zhen, and Z. Wenlin, Determination of nitrosamine impurities in losartan potassium drug substance and drug product using the Xevo TQ-S micro and Atlantis premier BEH C18 AX column. Waters Corporation 720007393, 1–13 (2021).
L. Liangxing, L. Caiyun, X. Xueyi, G. Chongkai, and L. Ning, J. Chromatogr. Sci., 54, No. 8, 1415–1420 (2016); https://doi.org/10.1093/chromsci/bmw101.
Vijaya Kumari Karra, Nageswara Rao Pilli, Jaswanth Kumar Inamadugu, and J. V. L. N. Seshagiri Rao, Pharm. Methods, 3, No. 1, 18–25 (2012); https://doi.org/10.4103/2229-4708.97711.
C. Sandeep, S. Aman, M. Chandrasekar, and P. Manoj, Drug Discovery Develop., 2, 1–3 (2020).
M. Chander, B. Saikat, and V. Samir, Agilent Technol., 555, 1–4 (2020).
M. I. Walash, M. M. Sharaf El-Din, N. M. El-Enany, M. I. Eid, and S. M. Shalan, Chem. Central J., 6, No. 13, 1–12 (2012); https://doi.org/10.1186/1752-153x-6-13.
E. Souri, A. N. Aghdami, and N. Adib, Res. Pharm. Sci., 9, No. 3, 199–206 (2014).
Ahmed H. Naggar, Ahmed Kotb, Ahmed A. Gahlan, Mahmoud H. Mahross, Abd El-Aziz Y. El-Sayed, and Adel A. Abdelwahab, Chemosensors, 9, No. 2, 1–22 (2021), https://doi.org/10.3390/chemosensors9020035.
M. Abdulbari and A. Zainab, J. Phys.: Conf. Ser., 1032, No. 1, 1–9 (2018); https://doi.org/10.1088/1742-6596/1032/1/012064.
A. A. Othman, R. I. El-Bagary, E. F. Elkady, and M. M. El-Kerdawy, Pharm. Anal. Acta, 7, No. 7, 1–8 (2016); https://doi.org/10.4172/2153-2435.1000501.
Azza A. Attia, Alexandria J. Pharm. Sci., 8, No. 1, 15–18 (1994).
Farhan Ahmed Siddiqui, Nawab Sher, Najmul Hasan, Nighat Shafi , Hina Shamshad, Mansoor Ali Beg, Ali Akbar Sial, and Alisha Wafa Sial, World Appl. Sci. J., 32, No. 7, 1418–1422 (2014); https://doi.org/10.5829/idosi.wasj.2014.32.07.1120.
Safi la Naveed, Nimra Waheed, Safeena Nazeer, and Hina Rehman, Int. J. Appl. Sci.-Res. Rev., 2, No. 1, 1–5 (2015).
M. Parag and G. P. Senthilkumar, Am. J. Pharm. Res., 10, No. 1, 137–147 (2020); https://doi.org/10.46624/ajptr.2020.v10.i1.012.
Rania N. El-Shaheny and Fathalla F. Belal, J. Chem., 1, 1–9 (2015); https://doi.org/10.1155/2015/293719.
Mohamed I. Walash, Mohie M. Kh. Sharaf El-din, Nahed M. El-enany, Manal I. Eid, and Shereen M. Shalan, Chem. Central J., 6, No. 13, 1–12 (2012), https://doi.org/10.1186/1752-153X-6-13.
K. Sujana, M. Z. Hamuthal, V. S. Murthy, and N. Shravani, Pharm. Anal. Acta, 6, No. 1, 1–6 (2015); https://doi.org/10.4172/2153-2435.1000324.
A. A. Tamer, G. M. Gehad, and E. N. S. Adel, Egypt. J. Chem., 64, No. 7, 3323–3334 (2021); https://doi.org/10.21608/EJCHEM.2021.50147.3300.
H. M. K. K. Inas, J. Pure Appl. Sci., 31, No. 1, 75–87 (2018); https://doi.org/10.30526/31.1.1855.
S. T. Nagam and A. Y. Omar, Baghdad Sci. J., 18, No. 3, 565–574 (2021); https://doi.org/10.21123/bsj.2021.18.3.0565.
Nagham S. Turkey and Jalal N. Jeber, Baghdad Sci. J., 19, No. 1, 141–154 (2022); https://doi.org/10.21123/bsj.2022.19.1.0141
Nagham S. Turkey and Jalal N. Jeber, Chem. Chem. Technol., 16, No. 4, 600–613 (2022); https://doi.org/10.23939/chcht16.04.600.
V. Montazeralmahdi, A. Sheibani, and M. R. Shishehbore, J. Appl. Spectrosc., 86, 843–847 (2019); https://doi.org/10.1007/s10812-019-00904-3.
S. M. Soliman, H. M. Y. El-Agizy, and E. Abd El Aziz, J. Appl. Spectrosc., 81, 509–518 (2014); https://doi.org/10.1007/s10812-014-9963-0.
S. R. Patra, A. Bali, and M. Saha, J. Appl. Spectrosc., 88, 1088–1094 (2021); https://doi.org/10.1007/s10812-021-01284-3.
P. Singh and A. Bali, J. Appl. Spectrosc., 89, 1085–1091 (2023); https://doi.org/10.1007/s10812-023-01471-4.
I. A. Darwish, A. S. Khedr, H. F. Askal, and R. M. Mahmoud, J. Appl. Spectrosc., 73, 792–797 (2006); https://doi.org/10.1007/s10812-006-0157-2.
R. Chadha and A. Bali, J. Appl. Spectrosc., 83, No. 2, 288–293 (2016); https://doi.org/10.1007/s10812-016-0283-4.
S. K. Dash, S. K. Achariya, P. S. Das, N. K. Kumar, and Ch. N. Patra, J. Appl. Spectrosc., 88, No. 6, 1276–1283 (2022); https://doi.org/10.1007/s10812-022-01309-5.
Tanvi Gupta, Alka Bali, and Marella Mahesh, J. Appl. Spectrosc., 90, No. 4 (2023); https://doi.org/10.1007/s10812-023-01612-9.
Author information
Authors and Affiliations
Corresponding author
Additional information
Abstract of article is published in Zhurnal Prikladnoi Spektroskopii, Vol. 91, No. 3, p. 471, May–June, 2024.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Mohammed, M.A., Sadiq, K.A., Mezaal, E.N. et al. Spectrophotometric Method Using the Derivative for the Determination of the Drug Losartan. J Appl Spectrosc 91, 709–716 (2024). https://doi.org/10.1007/s10812-024-01774-0
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10812-024-01774-0