A very simple and sensitive spectrofluorimetric method was developed for the direct determination of losartan in some commercial tablets. The suggested method is based on the linear relationship between 0.1–5.0 μg/ml of losartan and its fluorescence intensity at 400 nm in acidic medium. The detection limit and relative standard deviation (for ten repetitive measurements of 2.0 μg/ml) were obtained as 12.0 ng/ml and 1.35%, respectively. The recommended method was successfully applied for the determination of losartan in three types of commercial tablets from different brands.
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Published in Zhurnal Prikladnoi Spektroskopii, Vol. 82, No. 5, pp. 784–787, September–October, 2015.
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Taher, M.A., Asadollahzadeh, H. & Fazelirad, H. A Simple Spectrofluorimetric Method for the Determination of Losartan in Some Tablet Dosage Forms. J Appl Spectrosc 82, 842–844 (2015). https://doi.org/10.1007/s10812-015-0190-0
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DOI: https://doi.org/10.1007/s10812-015-0190-0