Threaded implants with bioactive coatings were studied. The implants under consideration were standard titanium screws modified with single- and bilayer coatings based on calcium phosphates and anatase. The effectiveness of their osseointegration was assessed in experiments on model animals using a biomechanical testing method and by computerized microtomography (micro-CT). The studies showed that the coatings not only stimulated the growth of bone tissue, but also increased the critical torque (to ~3.8-6.3 N·cm), at which point implant failure occurred.
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References
Isaacson, B. M. and Jeyapalina, S., “Osseointegration: A review of the fundamentals for assuring cementless skeletal fixation,” Orthoped. Res. Rev., 6, 55-65 (2014).
Spriano, S., Yamaguchi, S., Baino, F., and Ferraris, S., “A critical review of multifunctional titanium surfaces: New frontiers for improving osseointegration and host response, avoiding bacteria contamination,” Acta Biomaterialia, 79, 1-22 (2018).
Liu, Y., Rath, B., Tingart, M., and Eschweiler, J., “Role of implants surface modification in osseointegration: A systematic review,” J. Biomed. Mater. Res., 108A, No. 3, 470-484 (2020).
Biomedical Materials, R. Narayan (ed.), Springer: New York (2009).
Biological and Biomedical Coatings Handbook. Processing and Characterization, S. Zhang (ed.), CRC Press, Boca Raton (2011).
Kononovich, N. A., Stogov, M. V., Popkov, A. V., Gorbach, E. N., Kireeva, E. A., Tushina, N. V., and Popkov, D. A., “Kinetics of calcium and phosphate release from the surface of implants coated using different techniques,” Biomed. Eng., 53, 190-193 (2019).
Lyasnikov, V. N., Lyasnikova, A. V., Pivovarov, A. V., Antonov, I. N., and Papshev, V. A., “Study of structure of bioceramic coatings obtained by plasma spraying of hydroxyapatites of synthetic and biological origins,” Biomed. Eng., 45, Article No. 119 (2011).
Lopez-Valverde, N., Lopez-Valverde, A., Aragones, J. M., de Sousa, B. M., Rodrigues, M. J., and Ramirez, J. M., “Systematic review and meta-analysis of the effectiveness of calcium-phosphate coating on the osseointegration of titanium implants,” Materials, 14, No. 11, 3015 (2021).
Skriabin, A. S., Tsygankov, P. A., Vesnin, V. R., Parshin, B. A., Zaitsev, V. V., and Lukina, Yu. S., “Physicochemical properties and osseointegration of titanium implants with bioactive calcium phosphate coatings produced by detonation spraying,” Inorg. Mater., 58, No. 1, 71-77 (2022).
He, T., Cao, C., Xu, Z., Li, G., Cao, H., Liu, X., Zhang, C., and Dong, Y., “A comparison of micro-CT and histomorphometry for evaluation of osseointegration of PEO-coated titanium implants in a rat model,” Sci. Rep., 7, Article 16270 (2017).
Swami, V. and Vij ayaraghavan, V., “Current trends to measure implant stability,” J. Indian Prosthodont. Soc., 16, No. 2, 124-130 (2016).
Cho, S. A. and Park, K. T., “The removal torque of titanium screw inserted in rabbit tibia treated by dual acid etching,” Biomaterials, 24, No. 20, 3611-3617 (2003).
Simeone, S. G., Rios, M., and Simonpietri, J., “Reverse torque of 30 Ncm applied to dental implants as test for osseointegration – A human observational study,” Int. J. Implant Dent., 2, Article 26 (2016).
Tsygankov, P. A., Skryabin, A. S., Krikorov, A. A., Chelmodeev, R. I., Vesnin, V. R., and Parada-Becerra, F. F., “Formation of a combined bioceramics layer on titanium implants,” J. Phys. Conf. Ser., 1386, No. 1, Article 012011 (2019).
Klui, N. I., Choryi, V. S., Zatovsky, I. V., Tsabiy, L. I., Buryanov, A. A., Protsenko, V. V., Temchenko, V. P., Skryshevsky, V. A., Glasmacher, B., and Gryshkov, O., “Properties of gas detonation ceramic coatings and their effect on the osseointegration of titanium implants for bone defect replacement,” Ceram. Int., 47, No. 18, 25,425-25,439 (2021).
Tsygankov, P. A., Skriabin, A. S., Telekh, V. D., Loktionov, E. Yu., and Chelmodeev, R. Yu., “Interaction between dusty shock waves and three-dimensional scaffolds of carbon nanocomposites upon the deposition of biocompatible coatings,” Bull. Russ. Acad. Sci. Phys., 82, No. 4, 380-385 (2018).
Rakhadilov, B. and Baizhanov, D., “Creation of bioceramic coatings on the surface of Ti-6Al-4V alloy by plasma electrolytic oxidation followed by gas detonation spraying,” Coatings, 11, No. 12, Article 1433 (2021).
Kalita, V. I., Komlev, D. I., Radyuk, A. A., Komlev, V. S., Shamrai, V. F., Sirotkin, V. P., and Fedotov, A. Yu., “Dependence of the phase composition of phosphate plasma coatings on support temperature and hydrothermal processing,” Neorgan. Materialy, 57, No. 6, 627-631 (2021).
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Skryabin, A.S., Shakurov, A.V., Chelmodeev, R.I. et al. Biomechanical and Microtomographic Assessment of the Effectiveness of Osseointegration of Threaded Titanium Implants with Single- and Bilayer Bioceramic Coatings. Biomed Eng 56, 142–145 (2022). https://doi.org/10.1007/s10527-022-10185-4
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DOI: https://doi.org/10.1007/s10527-022-10185-4