A stable preparation of agaricinic acid nanoparticles was obtained. The mean hydrodynamic size of nanoparticles according to photon correlation spectroscopy was 200 nm and zeta potential was -57 mV. Cytotoxic activity of agaricinic acid nanoparticles against human HepG2 hepatoma cells was evaluated. Nanoparticles with a low concentration of agaricinic acid stimulated and with high concentration — suppressed metabolic activity and viability of hepatoma cells. The EC50 for the stimulating effect was 32.8 μg/ml, and the IC50=602.1 mg/ml. The preparation of agaricinic acid nanoparticles can be used in medicine as a potential antitumor agent.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 4, pp. 495-498, April, 2020
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Gudkova, O.I., Demchenko, A.G., Shvets, A.V. et al. Biological Activity of Agaricinic Acid Nanoparticles against Human Hepatoma HepG2 Cells. Bull Exp Biol Med 169, 508–511 (2020). https://doi.org/10.1007/s10517-020-04919-1
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DOI: https://doi.org/10.1007/s10517-020-04919-1