We studied the effect of α2-adrenoreceptor agonist clonidine hydrochloride in concentrations of 10—9-10—6 M on inotropy, chronotropy, and coronary flow in Langendorff-isolated heart of adult rats. It was found that α2-adrenoreceptor agonist changed all studied parameters. Left ventricular myocardium contraction force decreased after application of all tested concentrations, the maximum effect was observed at a concentration of 10—6 M. Stimulation of α2-adrenergic receptors in concentrations of 10—8, 10—7, and 10—6 M produced a two-phase effect (initial increase and a subsequent decrease) on the coronary flow. Clonidine hydrochloride in the maximum concentration (10—6 M) caused a decrease in HR in one group and an increase in the other.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 5, pp. 532-535, May, 2018.
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Ziyatdinova, N.I., Kuptsova, A.M., Faskhutdinov, L.I. et al. Effect of α2-Adrenoceptor Stimulation on Functional Parameters of Langendorff-Isolated Rat Heart. Bull Exp Biol Med 165, 593–596 (2018). https://doi.org/10.1007/s10517-018-4220-9
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DOI: https://doi.org/10.1007/s10517-018-4220-9