Introduction

Approximately 35% of patients with non-small cell lung cancer (NSCLC) are diagnosed with stage I–IIIA disease [1, 2] and eligible to undergo curative-intent therapy through a combination of lung cancer resection surgery, definitive radiation, or concurrent chemoradiation. The number of earlier stage lung cancer is expected to increase [3] given the findings of the US National Lung Screening Trial [4], and many professional societies [5,6,7,8,9] endorsing lung cancer screening with low-dose computed tomography in high-risk individuals. Immediately following curative-intent therapy, lung cancer patients are at risk for worsening health due to the toxicities and side effects of treatment. Depending on the extent of resection, a loss of 10–15% of lung function is expected at 3–6 months following lung cancer resection surgery and may persist at 1 year [10]. In addition, perioperative pulmonary [11] and cardiopulmonary [12] complications occur in 15% and 35% of patients, respectively, and can lead to negative health consequences beyond the perioperative period. In those undergoing definitive radiation, 5–15% will develop radiation pneumonitis [13] and worsening respiratory symptoms. Patients undergoing chemotherapy including adjuvant therapy can experience neutropenia, cardiac ischemia, heart failure (HF), neuropathy, and worsening fatigue. Also, lung cancer patients have major comorbidities including chronic obstructive pulmonary disease (COPD, present in approximately 50% of patients) due to tobacco exposure and heart failure (approximately 13%) [14], the health effects of which can be exacerbated by lung cancer treatment.

The identification and quantification of peri-treatment changes in health may identify important decrements which can be prevented and/or minimized to improve lung cancer morbidity and mortality. In addition, peri-treatment efforts to optimize cardiopulmonary function and reduce symptom burden may improve lung cancer survivors’ quality of life (QoL) and survival. In this project, we assessed the changes in health as reflected by functional exercise testing and patient-reported outcomes (PROs). We hypothesized that curative-intent therapy of stage I–IIIA lung cancer is associated with decrements in health as reflected by functional exercise capacity (EC) and cancer-specific QoL.

Methods

Study overview

We performed a prospective, observational cohort study of patients undergoing curative-intent therapy for lung cancer. We identified eligible patients from a weekly list of consecutive cases presented at the VA San Diego Healthcare System (VASDHS) chest tumor board (CTB). We included adult lung cancer patients with clinical stage I–IIIA disease who are recommended by the CTB to undergo lung cancer resection surgery, definitive radio-ablation, or concurrent chemoradiation as the primary mode of the treatment. We excluded patients undergoing concurrent systemic therapy for other cancers or those physically unable to perform functional EC evaluation (e.g., quadriplegia or amputees) (Fig. 1).

Fig. 1
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Flow diagram of enrolled participants

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Between August 2016 and March 2018, we mailed informational letters to eligible patients after CTB management plans were communicated to patients and followed up with a telephone call approximately 1 week later to gauge their interest. Patients who were interested and willing to participate in our study were scheduled in-person visits, during which all were provided written informed consent prior to study procedures. Outcome assessments were performed between August 2016 and May 2018, both before and at 1 to 3 months after completion of therapy. We followed the STROBE guideline recommendations to report our findings [15]. The VASDHS Institutional Review Board approved this protocol (#H150158).

Covariates

We collected baseline clinical characteristics and potential confounders important in lung cancer and cardiopulmonary health and QoL, including age, sex, body mass index, tobacco exposure, comorbidities (including COPD, HF, and psychiatric illness), lung function, and echocardiographic findings where available; lung cancer–related information included histologic subtype, clinical stage, and primary treatment modality. All covariates were abstracted from the electronic health records and verified by a board-certified physician with subspecialty training in pulmonology (DH).

Functional EC and PRO assessments

Our primary endpoint was functional EC as assessed by the six-minute walk test (6MWT) distance (6MWD). We chose the 6MWT [16] based on practical considerations of availability, ease of performance for testing, and the likelihood that daily activities of living are performed at submaximal exercise intensity. In lung cancer survivors, the 6MWD has concurrent validity against cardiopulmonary fitness [17], discriminant validity compared to age-, sex-, height-, and weight-matched adults [18], predictive validity for cancer-specific QoL [18], responsiveness to treatment [19], and a defined minimal clinically important difference (MCID) for interpretation (22–42 m, or a change of 9.5%) [19]. We performed the 6MWT according to the standard protocol at the VASDHS which follows the American Thoracic Society recommendations [20].

Our secondary endpoint was a validated composite score of cancer-specific QoL, assessed by the European Organization for Research and Treatment of Cancer QoL Questionnaire Core 30 (EORTC-QLQ-C30) summary score [21]. We chose the EORTC-QLQ-C30 [22] based on availability, inclusion of core domains of QoL and other subdomains relevant to lung cancer (e.g., dyspnea, fatigue, pain), and a validated summary score [21] to avoid multiple testing of individual health domains. We also performed exploratory PRO assessments for lung cancer-specific symptoms, generic health, sleep quality, dyspnea, fatigue, and anxiety/depression using the EORTC-QLQ-Lung Cancer Module 13 (LC13) [23], EuroQoL-5 Dimensions/visual analogue scale (EQ-5D/VAS) [24], Pittsburgh Sleep Quality Index (PSQI) [25], University California San Diego Shortness of Breath Questionnaire (UCSD SOBQ) [26], Brief Fatigue Inventory (BFI) [27], and Hospital Anxiety and Depression Scale (HADS) [28] questionnaires, respectively. We used separate PRO questionnaires and not the EORTC subscales to assess dyspnea and fatigue because these two symptoms are assessed by only one and three questions, respectively, on the EORTC-QLQ-C30 [22], and three and zero questions, respectively, on the LC13 [23]. We administered all questionnaires in-person when possible and on printed forms without modifications; all questionnaires were scored as per their respective instruction manuals.

We interpreted results using the MCIDs (for the respective questionnaires) where available, 0.06 points (EQ-5D US-index [29]), 7 points (EQ-5D VAS [29]), 3 points (PSQI [30]) 5 points (UCSD SOBQ [31]), 7 points (BFI [27]), and 1.5 points (HADS subscales [32]). Since the MCID for the EORTC-QLQ-C30 summary score is not yet established, we calculated a range of MCID using 0.2 to 0.5 standard deviations of the mean [33] using the data from a previous study [18] of lung cancer survivors following curative intent therapy, 3.6 to 9.0 points.

Sample size

We calculated sample sizes assuming a significance level of p < 0.05 in two-tailed tests, and 80% power to detect a difference in outcomes. For our primary endpoint, we calculated that a sample size of 29 participants will be needed, using a MCID in the 6MWD of 40 m [34] and standard deviation (SD) of 74 m as reported by previous literature [19]. For our secondary endpoint, we calculated a sample size of 30 participants based on a decline of 9 EORTC-QLQ-C30 summary score points following surgical lung cancer treatment [35] and SD of 17 as reported by previous literature [21]. These calculations were performed using PS Power and Sample Size Calculations software, version 3.0.

Statistical analyses

We summarized descriptive statistics as appropriate. All outcomes were recorded and analyzed as continuous variables. To examine the distribution of outcome variables, we visually inspected all histograms and used skewness and kurtosis distribution statistics of ± 2 to define normal distribution [36]. We interpreted the 6MWD using the reference equations in healthy adults [37] and PROs using reference values where available [38]. We used the paired sample t tests and multivariable generalized estimating equations (GEE) models to assess and analyze the effects of time and/or treatment on outcomes. We chose GEE models as they generally provide better model fits compared with linear mixed effects models for studies with a relatively large sample size (N > 30) and few follow-up assessments [39]. To identify potential confounders, we used univariable (UVA) and multivariable (MVA) linear regression analyses to assess the relationship between baseline characteristics and the outcome of interest. We performed MVAs using stepwise backward selection modeling including all baseline characteristics with p < 0.20. We used model R-squared and adjusted R-squared values to gauge model fitting, and defined overfitting as a difference of ≥ 20% in adjusted and unadjusted R-squared [40]; those in the final MVA models were selected to enter multivariable GEE models. We further selected for covariates included in the final GEE models using stepwise backwards selection and p value cutoff < 0.20. To investigate the effect of treatment on outcomes, the effect of time (pre-/post-treatment) was forced into the model regardless of statistical significance. We also performed a pre-specified subgroup analysis of stage I lung cancer patients to compare the effects of surgery vs definitive radio-ablation on outcomes. We used beta coefficients (β) and 95% CIs to describe effect size and defined statistical significance as p < 0.05 in two-tailed tests. All data were analyzed using IBM® SPSS® Statistics software version 24.0.

Results

Participants

We screened 55 stage I–IIIA lung cancer patients, mailed recruitment letters to 50 eligible, and had a final enrollment of 35 participants (Fig. 1); their baseline characteristics are summarized in Table 1. Most had a tobacco exposure history (32 participants, 91%), COPD (25, 71%), and stage I disease (29, 83%). There were no significant differences in baseline clinical characteristics for participants compared with non-participants except for a higher proportion of non-participants having stage II–IIIA disease (E-Table 1).

Table 1 Participant characteristics
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Baseline functional EC and PRO assessments

Participants’ baseline functional EC was low (mean 6MWD = 370 m (69% predicted) and impaired in 24 participants (69%) (Table 2)). Cancer-specific QoL was also reduced (mean = 72.0 points on scale range 0–100). Approximately, half of the participants reported abnormal physical function, pain, insomnia, appetite loss, or dyspnea on the EORTC-QLQ-C30/LC-13 (Table 2) questionnaire (defined as raw scores < mean reference value for functional scales and raw scores > mean reference value for symptom scales [38]). Baseline exploratory outcome assessments are summarized in Table 2.

Table 2 Baseline functional EC and PRO assessments (N = 35)
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Curative-intent treatment

All but two participants underwent either surgical resection, definitive radio-ablative therapy, or concurrent chemoradiation for treatment. Of the 18 (51%) participants who underwent surgical resection, all but two received lobectomy; one underwent pneumonectomy due a central tumor location, and another underwent wedge resection due to poor lung function and planned stereotactic body radiotherapy (SBRT) for a synchronous primary lung cancer (follow-up outcome assessments were obtained after wedge resection in this participant); no participant received adjuvant chemo- or radiotherapy. Among the 12 (34%) participants who underwent definitive radio-ablative therapy, all but two received SBRT; one received cryoablation due to a history of pneumonitis following radiotherapy for a previous primary lung cancer, and another received radiofrequency ablation (RFA) and SBRT for synchronous primary lung cancers (follow-up outcome assessments were obtained following completion of SBRT and RFA). Of the 5 (14%) participants undergoing concurrent chemoradiation, two received tri-modality therapy (follow-up assessments were performed at 1 to 3 months following completion lobectomy in these participants). No participant with stage I disease received adjuvant (chemo- or radio-) therapy. We provided in-depth treatment-associated morbidities in our online data supplements.

Completion of follow-up assessments

Following treatment, 28 (80%) of the 35 participants completed the follow-up 6MWT and 31 (89%) completed the PRO questionnaires. Two participants had transportation challenges and declined the follow-up 6MWT but completed PRO questionnaires remotely (one via mail and another via telephone). Three participants did not have regular follow-up clinic visits and/or transportation challenges and, therefore, did not complete either 6MWT or PRO re-assessments within the 1–3-month post-treatment period. One participant suffered medical complications following treatment and died during the follow-up period.

Effect of treatment on outcomes

Following curative-intent therapy, there was a possibly clinically meaningful (and statistically non-significant) decrease in the primary outcome functional EC (mean change (95% CI) 6MWD = − 25.5 m (− 58.4, + 7.3), p = 0.12)) (Fig. 2a (i), as well as possibly clinically meaningful (and statistically non-significant) decrease in the secondary outcome cancer-specific QoL (EORTC-QLQ-C30 summary score = − 3.89 (− 10.9, + 3.08), p = 0.26)) (Fig. 2a (ii) as assessed by the paired sample t tests. Exploratory outcome assessments showed that dyspnea (mean change (95% CI) UCSD SOBQ = + 12.9 (+ 4.77, + 21.0), p = 0.003) (Fig. 2a (iii) and fatigue (BFI = + 10.4 points (+ 2.87, + 17.9), p = 0.008) (Fig. 2a (iv) scores were clinically higher/worse following treatment and no clinically meaningful changes in other exploratory outcomes listed in Table 2.

Fig. 2
figure 2

a Changes in primary, secondary, and significant exploratory outcomes associated with curative-intent lung cancer treatment. i Functional EC (primary outcome); complete follow-up data in 28 participants; mean difference (post-/pre-treatment) = − 25.5 m (95% CI – 58.4, + 7.29), p = 0.12. ii Cancer-specific QoL (secondary outcome); complete follow-up data in 31 participants; mean difference (post-/pre-treatment) = − 3.89 points (95% CI – 10.9, + 3.08), p = 0.26. iii Dyspnea (UCSD SOBQ, significant exploratory outcome) complete data in 30 participants; mean difference (post-/pre-treatment) = + 12.9 points (95% CI + 4.77, + 21.0), p = 0.003. iv Fatigue (BFI, significant exploratory outcome); complete data in 31 participants; mean difference (post-/pre-treatment) = + 10.4 points (95% CI + 2.87, + 17.9), p = 0.008. b Changes in primary, secondary, and significant exploratory outcomes for stage I lung cancer stratified by treatment. i Functional EC (primary outcome); complete response and follow-up in 13 participants for surgical resection and 11 for definitive radio-ablation; no significant between-treatment effect (p = 0.77). ii Cancer-specific QoL (secondary outcome); complete response and follow-up in 14 participants for surgical resection and 12 for definitive radio-ablation; significant between-treatment effect (p = 0.04). iii Dyspnea (UCSD SOBQ, exploratory outcome); complete response and follow-up in 14 participants for surgical resection and 12 for definitive radio-ablation; no significant between-treatment effect (p = 0.77). iv Fatigue (BFI, exploratory outcome); complete response and follow-up in 14 participants for surgical resection and 12 for definitive radio-ablation; no significant between-treatment effect (p = 0.45). Horizontal lines inside the boxes represent the median values, ends of boxes represent upper and lower quartiles, and whiskers represent highest and lowest observations. BFI, brief fatigue inventory; EC, exercise capacity; QoL, quality of life; UCSD SOBQ, University of California San Diego Shortness of Breath Questionnaire

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Results of UVAs and MVAs to identify baseline clinical characteristics associated with the endpoints are shown in E-Tables 2–5. In multivariable GEEs adjusting for all confounders associated with the outcomes, the effect of time (pre-/post-treatment) was associated with possibly clinically meaningful decrements in functional EC (mean 6MWD change − 25.4 m, p = 0.096) (Table 3) and no clinically meaningful decrease in cancer-specific QoL (mean EORTC-QLQ-C30 summary score change − 3.39 points, p = 0.30) (Table 4); dyspnea (mean UCSD SOBQ increase 13.1 points, p = 0.001) (Table 5) and fatigue (mean BFI increase 9.97 points, p = 0.006) (Table 6) symptoms were clinically higher/worse following treatment.

Table 3 Multivariable GEE analyses of the effects of curative-intent lung cancer treatment on outcomes (N = 35). Functional EC (primary outcome, 6MWD)
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Table 4 Multivariable GEE analyses of the effects of curative-intent lung cancer treatment on outcomes (N = 35). Cancer-specific QoL (secondary outcome, EORTC-QLQ-C30 summary score)
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Table 5 Multivariable GEE analyses of the effects of curative-intent lung cancer treatment on outcomes (N = 35). Dyspnea (significant exploratory outcome, UCSD SOBQ)
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Table 6 Multivariable GEE analyses of the effects of curative-intent lung cancer treatment on outcomes (N = 35). Fatigue (significant exploratory outcome, BFI)
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In a pre-specified subgroup analysis of stage I patients (N = 29) to compare the effects of surgical resection (n = 17, 59%) vs definitive radio-ablation (n = 12, 41%) on outcomes (Fig. 2b), surgical treatment resulted in a clinically meaningful higher decrement in the secondary outcome cancer-specific QoL following treatment (mean change − 15.1 points (− 0.83, − 29.4), p = 0.04) (Table 7), but no clinically meaningful differences in the primary outcome functional EC (Table 8) or exploratory outcomes dyspnea or fatigue as assessed by the UCSD SOBQ (Table 9) or BFI (Table 10), respectively. The effects of time (pre-/post-treatment) for stage I patients are also shown in Tables 7, 8, 9, and 10.

Table 7 Subgroup multivariable GEE analyses on the effects of surgical treatment compared with definitive radio-ablation on outcomes in stage I patients (N = 29). Cancer-specific QoL (secondary outcome, EORTC-QLQ-C30 summary score)
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Table 8 Subgroup multivariable GEE analyses on the effects of surgical treatment compared with definitive radio-ablation on outcomes in stage I patients (N = 29). Functional EC (primary outcome, 6MWD)
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Table 9 Subgroup multivariable GEE analyses on the effects of surgical treatment compared with definitive radio-ablation on outcomes in stage I patients (N = 29). Dyspnea (exploratory outcome, UCSD SOBQ)
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Table 10 Subgroup multivariable GEE analyses on the effects of surgical treatment compared with definitive radio-ablation on outcomes in stage I patients (N = 29). Fatigue (exploratory outcome, BFI)
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Discussion

In a prospective, observational cohort study of stage I–IIIA lung cancer patients undergoing curative-intent therapy, we observed (1) a possibly clinically meaningful decline in functional EC, the primary outcome; (2) no clinically meaningful change in the secondary outcome, cancer-specific QoL; and (3) clinically meaningful worsening of exploratory outcomes dyspnea and fatigue symptoms at 1 to 3 months following treatment completion.

Much of the attention on the effects of curative-intent lung cancer therapy focuses on physiological (i.e., lung function and maximal/peak EC) and clinical (i.e., perioperative morbidity and mortality) outcomes [41]. Currently, there is a lack of clinical emphasis on patient-centered outcomes (e.g., functional EC and cancer-specific QoL) which may be more important than survival for some patients [42]. As such, in its most recent clinical guideline for follow-up and surveillance after curative-intent therapy of lung cancer, the American College of Chest Physicians called for additional research to clarify which curative-intent treatment modalities affect QoL the most and to identify patients who are at the most risk for impairments after treatment [43].

The 6MWD is an important patient-centered and functional outcome associated with perioperative complications [44] and survival [45] in patients with early stage lung cancer [16]. To the best of our knowledge, only two previous studies (both by Granger and colleagues [34, 46]) examined the effects of stage I–III lung cancer treatment on functional EC. In both studies, the authors reported clinically and statistically significant declines in the 6MWD following lung cancer resection surgery. While our study did not detect a statistically significant change, the 25-m reduction is likely clinically significant as suggested by another analysis reporting 6MWD changes of 22–42 m as the MCID in the lung cancer population [19]. Our study also provides complementary information to a study by Granger and colleagues which reported a 43-m reduction in 6MWD in a cohort of 40 stage I–IIIB lung cancer survivors at 10 weeks following diagnosis. In contrast to their study, we excluded patients with stage IIIB disease and those undergoing palliative therapy or sequential chemoradiation, thereby targeting a different patient population (i.e., those undergoing curative-intent therapy). Moreover, whereas some of the follow-up assessments in the study by Granger and colleagues were performed before or during the course of treatment [34]; all our follow-up assessments were performed after completion of curative-intent therapy, providing additional insights into their post-treatment course.

While lacking long-term follow-up, our study adds to existing literature [47,48,49,50,51,52,53,54] on the effects of curative-intent lung cancer treatment on PROs and QoL. Among the largest studies to date, Brunelli and colleagues [52] reported that in 156 consecutive patients undergoing lung cancer resection surgery, the physical composite scale in the generic QoL was significantly reduced at 1 month but completely recovered at 3 months, and the mental composite scale remained unchanged. In the same study, the authors also found poor correlation (coefficients < 0.2) between these generic health measures and FEV1, DLCO, and EC as assessed by the height reached on the stair-climbing test [52]. In contrast, in a study with 2-year follow-up, Ilonen and colleagues [53] observed that in 53 patients undergoing lung cancer resection surgery, the generic QoL was decreased compared with preoperative values at 3, 12, and 24 months following surgery. They also found no correlation between preoperative FEV1 or DLCO and QoL at any of the follow-up assessment time points [53]. Similarly, in a prospective cohort study of 131 lung cancer patients undergoing lobectomy or bilobectomy, Schulte and colleagues [54] found that most health domains, including physical function, pain, and dyspnea, were significantly impaired after surgery and remained so for up to 24 months following treatment.

While these contrasting findings may partly be due to differences in baseline characteristics of included patients and surgical techniques used (open thoracotomy vs video-/robotic-assisted thoracoscopy), standard physiological outcome assessments including pulmonary function testing do not appear to adequately capture all the effects of curative-intent lung cancer treatment on health. Also, these studies suggest that results may vary depending on the PRO or QoL instruments used, possibly due to a lack of a validated questionnaire for lung cancer patients undergoing curative-intent therapy, variations in psychometric properties between instruments including sensitivity to change, or the availability of a composite score to avoid multiple testing and minimize chance bias. To the best of our knowledge, our study is among the first to examine the effects of curative-intent lung cancer therapy on cancer-specific QoL using a validated, composite, summary score [21], suggested to be more sensitive to change compared with traditional QoL scores [35].

In contrast to previous studies that used a cross-sectional design [18, 55,56,57], our study is among the first to use the UCSD SOBQ and BFI questionnaires to prospectively assess changes in dyspnea and fatigue, respectively, in patients undergoing curative-intent therapy. While the EORTC-QLQ-C30 [22]/LC13 [23] questionnaires are commonly used cancer-/lung cancer–specific PRO instruments, dyspnea and fatigue—two important and commonly abnormal symptoms in lung cancer patients—are assessed by only one and three questions, respectively, in the 30-question EORTC-QLQ-C30, and only three and zero questions, respectively, in the 13-question EORTC-QLQ-LC13. While there are ongoing efforts to create a novel EORTC-QLQ-LC29 instrument with a summary score [58] to more accurately capture lung cancer-specific health, we used separate PRO questionnaires with more questions specifically on these two important symptoms (24 items in the UCSD SOBQ and 9 in the BFI). In this small sample, we detected clinically meaningful and statistically significant increases/worsening in dyspnea and fatigue symptoms following treatment.

Curative-intent therapy of stage I–IIIA lung cancer is heterogenous and uses a combination of treatment modalities and varies according to stage and clinical assessment of fitness to tolerate treatment. To this end, we performed a pre-specified subgroup analysis of stage I patients to compare the effects of surgical vs radio-ablative therapy. Similar to the entire cohort, our subgroup analysis showed a possibly clinically meaningful decline in functional EC and clinically meaningful higher/worsening of dyspnea and fatigue associated with stage I lung cancer treatment. Compared with radio-ablation, surgical resection may lead to greater decrement in cancer-specific QoL at 1 to 3 months following treatment. While the sample sizes are small and selected, these findings are similar to a recent exploratory analysis of a RCT involving 22 stage IA NSCLC patients to investigate the effects of surgical resection vs SBRT on global QoL [59]. To the best of our knowledge, our subgroup analysis is among the first to prospectively examine the effects of surgical vs definitive radio-ablative therapy in stage I lung cancer patients using a validated, composite, cancer-specific QoL score. As the number of early stage lung cancer survivors increases due to advances in screening and treatment techniques, these findings have implications in future studies involving the shared decision-making, treatment selection, and/or post-treatment care for these patients.

Many adult cancer survivors can experience reduced QoL as the result of physical impairments which can go undetected and untreated and result in disability [60]. In lung cancer patients, systematic reviews suggest that preoperative exercise training improves cardiopulmonary fitness and may reduce surgical complications [61], while postoperative training may improve exercise capacity and QoL [62]. While these findings support the utility of exercise to improve lung cancer–related outcomes, these studies can be affected by volunteer and selection bias and inadequate sample size [61, 62]. Our exploratory PRO assessments suggest that decreasing symptom burden due to dyspnea and fatigue (e.g., through optimizing medical therapy for cardiopulmonary disease) may be important to improve exercise, function, and/or QoL in these patients (E-Fig. 1).

Our study has limitations. First, the small sample size may not be adequately powered to detect statistically significant differences in the primary or secondary outcomes and pre-disposes our multivariable models to overfitting. Second, the range of 1 to 3 months for follow-up assessments may lead to additional variations in the outcomes measured and, therefore, diminished statistical power. Third, the absence of long-term follow-up assessments limits our ability to draw conclusions on the effect of time on outcomes including exploratory variables following treatment. For instance, it is possible that some of the worsening in dyspnea and fatigue may improve spontaneously after the 3-month follow-up period. Finally, our findings may have limited generalizability due to it being a single-institutional study involving a predominantly white male veteran patient population with a significant tobacco exposure and higher than expected prevalence of comorbidities, including coronary artery disease and COPD [14].

The strengths of our study include pre-specified primary, secondary, and exploratory outcomes to minimize chance bias. In addition, all baseline and most follow-up functional EC and PRO assessments were performed in-person by one observer (DH), maximizing the completeness and accuracy of the data collected and minimizing inter-observer variability. Equally important, we had a high completion rate (at least 80%) on all outcomes measured, maximizing the validity of our findings. In addition, unlike many of the published studies to date, we used multivariable GEE analyses to adjust for baseline characteristics including lung function associated with the outcomes enhancing our conclusions. Finally, we provided detailed descriptions of important clinical events following curative-intent lung cancer treatment and interpreted outcome changes using MCIDs, facilitating translation to the clinical setting.

We conclude that in a prospective observational cohort study of lung cancer patients undergoing curative-intent therapy, there were clinically meaningful and statistically significant worsening of dyspnea and fatigue symptoms, possible decreases in functional EC, but no significant change in cancer-specific QoL at 1 to 3 months following treatment. In stage I lung cancer patients, surgical treatment may lead to a greater decrement in cancer-specific QoL compared with definitive radio-ablative therapy. These results provide a proof-of-concept on the information provided by physio-psychological assessments in this patient population and may facilitate future studies to reduce symptom burden, and/or improve functional EC and QoL.