Abstract
Purpose
Since the relationship between postoperative platelet count and prognosis is still unclear, we designed a standardized index of platelet count to predict the prognosis of gastric cancer (GC).
Methods
We designed a development validation cohort for the pre/post platelet ratio. We determined the ability of PPR to predict mortality in gastric cancer patients and validated them by a separate cohort. Survival was assessed by Kaplan–Meier analysis and associations explored by multivariate and multivariate analyses. The usefulness of the prediction was estimated by measuring the time-dependent ROC. Decision-curve analysis was used to validate the net clinical benefit.
Results
The sample distribution was similar in the two cohorts, and the 1-, 3-, and 5-year OS evaluation of the postoperative/preoperative platelet ratio was the largest for AUC in the two cohorts. Meanwhile, PPR has a good predictive value and a net clinical benefit.
Conclusions
PPR has been identified and validated to be independently concerned about OS of patients with GC and was a reliable and economic indicator to evaluate the prognosis.
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Data availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Funding
This work was supported by Wenzhou Municipal Science and Technology Bureau,China. Grant numbers Y20210250.
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by JL, XY, XW, ZW, XS, ZL. The first draft of the manuscript was written by JL and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Li, J., Yang, X., Wang, X. et al. Predicting the prognosis of operable gastric cancer patients by dynamic changes in platelets before and after surgery: a retrospective cohort study. J Cancer Res Clin Oncol 149, 15479–15487 (2023). https://doi.org/10.1007/s00432-023-05334-5
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DOI: https://doi.org/10.1007/s00432-023-05334-5