Abstract
Objectives
To compare the image quality of the lungs between ultra-high-resolution CT (U-HRCT) and conventional area detector CT (AD-CT) images.
Methods
Image data of slit phantoms (0.35, 0.30, and 0.15 mm) and 11 cadaveric human lungs were acquired by both U-HRCT and AD-CT devices. U-HRCT images were obtained with three acquisition modes: normal mode (U-HRCTN: 896 channels, 0.5 mm × 80 rows; 512 matrix), super-high-resolution mode (U-HRCTSHR: 1792 channels, 0.25 mm × 160 rows; 1024 matrix), and volume mode (U-HRCTSHR-VOL: non-helical acquisition with U-HRCTSHR). AD-CT images were obtained with the same conditions as U-HRCTN. Three independent observers scored normal anatomical structures (vessels and bronchi), abnormal CT findings (faint nodules, solid nodules, ground-glass opacity, consolidation, emphysema, interlobular septal thickening, intralobular reticular opacities, bronchovascular bundle thickening, bronchiectasis, and honeycombing), noise, artifacts, and overall image quality on a 3-point scale (1 = worst, 2 = equal, 3 = best) compared with U-HRCTN. Noise values were calculated quantitatively.
Results
U-HRCT could depict a 0.15-mm slit. Both U-HRCTSHR and U-HRCTSHR-VOL significantly improved visualization of normal anatomical structures and abnormal CT findings, except for intralobular reticular opacities and reduced artifacts, compared with AD-CT (p < 0.014). Visually, U-HRCTSHR-VOL has less noise than U-HRCTSHR and AD-CT (p < 0.00001). Quantitative noise values were significantly higher in the following order: U-HRCTSHR (mean, 30.41), U-HRCTSHR-VOL (26.84), AD-CT (16.03), and U-HRCTN (15.14) (p < 0.0001). U-HRCTSHR and U-HRCTSHR-VOL resulted in significantly higher overall image quality than AD-CT and were almost equal to U-HRCTN (p < 0.0001).
Conclusions
Both U-HRCTSHR and U-HRCTSHR-VOL can provide higher image quality than AD-CT, while U-HRCTSHR-VOL was less noisy than U-HRCTSHR.
Key Points
• Ultra-high-resolution CT (U-HRCT) can improve spatial resolution.
• U-HRCT can reduce streak and dark band artifacts.
• U-HRCT can provide higher image quality than conventional area detector CT.
• In U-HRCT, the volume mode is less noisy than the super-high-resolution mode.
• U-HRCT may provide more detailed information about the lung anatomy and pathology.
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
Introduction
From the introduction of the first CT device in 1972 to the present day [1], computed tomography (CT) has become an essential imaging modality in a wide range of clinical applications through the incorporation of several innovative technologies. Thin-slice images of the whole lungs can be easily obtained within one breath hold by multidetector-row computed tomography (MDCT) [2]. Both hardware and software have been developed to acquire image data of wide spatial ranges in a short time, facilitated by faster gantry rotation speeds, a widening of detectors [e.g., 320-detector-row CT systems with area detectors (AD-CT)], higher generator power and increased stability of X-ray tubes, and detectors (e.g., garnet-based detectors) available in clinical settings [3,4,5,6]. Although the evolution toward faster scanning of a wider range is remarkable, there has been little progress in increasing spatial resolution over the last 30 years.
Regarding the spatial resolution, Imai et al. previously demonstrated improvements in spatial resolution using an experimental MDCT equipped with a density-double matrix detector [1824 channels (x-y plane) × 32 rows (z-axis) at a row width of 0.3125 mm] and an X-ray tube with an ultra-small focal spot [7]. This experimental CT device provided high-resolution imaging while maintaining low-contrast detectability, suggesting a potential for clinical use in areas requiring high spatial resolution, such as imaging of the inner ear, lungs, and bone. In 2017, the ultra-high-resolution CT (U-HRCT) device became available for clinical practice. Kakinuma et al. [8] reported on the performance of a U-HRCT prototype: a 4-row CT device with a detector element size of 0.25 × 0.25 mm at the isocenter and a beam collimation of 0.25 mm × 4 rows. The detector element size of the U-HRCT is half that of a conventional AD-CT in both the in-plane and body-axis directions. Current U-HRCT devices have detectors with 1792 channels in 160 rows. The minimum focus size (0.4 × 0.5 mm) is about a third of the area of a conventional ADCT device (0.9 × 0.8 mm), and the X-ray tube has also improved compared with conventional ADCT devices. By optimizing the relationship between the required radiation dose and focal spot size, a smaller focus size has become operational on the U-HRCT device.
The most advantageous feature of U-HRCT is its improved spatial resolution (120 micron) [8], which makes finer features distinguishable on CT images. No study so far has evaluated the image quality of current U-HRCT acquisitions. The purpose of this study was to compare the image quality of the lungs between U-HRCT and conventional AD-CT.
Materials and methods
This study was approved by the internal Ethics Review Board of our institute. Informed consent for the retrospective review of patient records and images and use of patient biomaterial was waived.
Phantom study
Image data of slit phantoms (Kyoto Kagaku Corp., Kyoto, Japan) made of stainless steel were acquired to evaluate the spatial resolution of AD-CT (Aquilion ONE™; Canon Medical Systems Corp., formerly Toshiba Medical Systems, Otawara, Tochigi, Japan) and U-HRCT (Aquilion Precision™; Canon Medical Systems Corp., Otawara, Tochigi, Japan). The slits (0.35, 0.30, and 0.15 mm) and intervening spaces were the same width in each phantom.
Image data of each phantom were acquired with both U-HRCT and AD-CT. The common acquisition parameters were as follows: gantry rotation period, 1.5 s; X-ray voltage, 120 kVp; tube current, 200 mA; field of view, 20 mm. The protocol for AD-CT was as follows: the number of channels per detector row, 896 channels and 0.5 mm × 4 rows; matrix size, 512. The U-HRCT was used in super-high-resolution mode (U-HRCTSHR: the number of channels per detector row, 1792 channels and 0.25 mm × 4 rows; matrix size, 1024). Axial thin-section CT images of 0.5 mm thickness were reconstructed using a lung kernel (FC81): the frequency range of the lung kernel for U-HRCT was twice as wide as that for AD-CT because the number of channels of the U-HRCT device was twice that of the AD-CT device.
Cadaveric human lungs and imaging
Eleven cadaveric human lungs were inflated and fixed using the Heitzman method [9]. These lungs were distended through the main bronchus with fixative fluid that contained polyethylene glycol 400, 95% ethyl alcohol, 40% formalin, and water in proportions of 10:5:2:3. The specimens were immersed in fixative fluid for 2 days and then air-dried. The pathological diagnoses of these 11 lungs were: pulmonary hemorrhage (n = 1), cardiogenic edema (n = 1), diffuse panbronchiolitis (n = 1), pulmonary tuberculosis (n = 2), pulmonary emphysema (n = 1), diffuse alveolar damage (n = 1), pulmonary metastasis (n = 1), pulmonary lymphangitic carcinomatosis (n = 1), and usual interstitial pneumonia (n = 2).
Image data of the 11 lungs were acquired with both U-HRCT and AD-CT. U-HRCT images were obtained with a 1.5-s gantry rotation, 160 mm field of view, 120 kVp, and three types of acquisition modes (see Online Supplementary Material): normal mode [U-HRCTN: the number of channels per detector row, 896 channels and 0.5 mm × 80 rows; matrix, 512; PF, 0.81; volumetric CT dose index (CTDIvol), 23.2 mGy]; super-high-resolution mode (U-HRCTSHR: the number of channels per detector row, 1792 channels and 0.25 mm × 160 rows; matrix, 1024; PF, 0.81; CTDIvol, 23.3 mGy); volume mode (U-HRCTSHR-VOL: the number of channels per detector row and matrix as in U-HRCTSHR; CTDIvol, 19.2 mGy). AD-CT images were obtained with the same parameters as U-HRCTN (but with CTDIvol, 23.9 mGy). Image data of the whole lungs were acquired on AD-CT and U-HRCT devices with three acquisition modes, respectively. On U-HRCTN images as reference, three cross-sectional levels with the most conspicuous CT findings were selected from each cadaveric human lung by three chest radiologists (A.H., M.Y., and O.H., with 8, 17, and 25 years of experience, respectively) 1 month before starting with the present evaluation. Two technologists (A.U. and S.T.) who were not involved in image evaluations recorded information on the anatomical structures (vessels and bronchi), abnormal CT findings, and artifacts in each cadaveric human lung. We obtained a total of 99 images (33 AD-CT images, 33 U-HRCTSHR images, and 33 U-HRCTSHR-VOL images) for evaluation and 33 U-HRCTN images for reference standard. Both U-HRCTSHR images and U-HRCTSHR-VOL images had the same three cross-sectional levels as U-HRCTN images because all image data were acquired on the same U-HRCT device. AD-CT images had almost the same three cross-sectional levels as U-HRCTN images. For comparison with AD-CT images with 0.5 mm thickness, all 132 axial thin-section CT images of 0.5 mm thickness were reconstructed using a lung kernel (FC81) and adaptive iterative dose reduction in three dimensions (ADIR 3D). All CT series were anonymized and transferred to a distant workstation viewer by two technologists (A.U. and S.T.) who were not involved in image evaluation.
Subjective image interpretation
Three independent chest radiologists (A.H., M.Y., and O.H. with 8, 17, and 25 years of experience, respectively) read all 132 images and evaluated them on a 8.3-megapixel, 32-inch color LCD (4K resolution) monitor without prior knowledge of histopathological diagnoses or image acquisition parameters. For each cadaveric human lung, AD-CT, U-HRCTSHR, and U-HRCTSHR-VOL images were evaluated simultaneously in a blinded manner using U-HRCTN images as reference. Images were displayed with a window level of -600 Hounsfield units (HU) and a window width of 1600 HU. The radiologists independently evaluated abnormal CT findings (faint nodules, solid nodules, ground-glass opacity, consolidation, emphysema, interlobular septal thickening, intralobular reticular opacities, bronchovascular bundle thickening, bronchiectasis, and honeycombing), normal anatomical structures (vessels and bronchi), and general aspects of image quality (subjective visual noise, streak artifacts, and dark band artifacts). Overall image quality was also evaluated for each image.
Overall image quality, abnormal CT findings, and normal anatomical structures were subjectively graded using a 3-point scale: ‘score 1’ indicated poor image quality (i.e., it was possible to detect structures but difficult to clearly evaluate their margin or internal characteristics); ‘score 2’ indicated fair image quality (i.e., the margin or internal characteristics can be detected and evaluated as well as in the reference images); ‘score 3’ indicated excellent image quality (i.e., it was easy to detect findings and to evaluate their margin or internal characteristics without any indistinct findings). Subjective visual noise and artifacts were also graded on a 3-point scale: ‘score 1’ indicated strong presence; ‘score 2’ indicated moderate presence (i.e., similar to those in the reference images); ‘score 3’ indicated slight presence or almost absence. On each reference image (U-HRCTN image), every visual evaluation item to be scored was indicated using colored markers by two technologists (A.U. and S.T.) so that the assessors could identify the position of each visual evaluation item to be evaluated on the other CT images (Fig. 1).
Objective image interpretation
Quantitative image noise measurements were calculated by measuring the standard deviation (SD) values in circular regions of interest (ROI) drawn on the workstation viewer. Quantitative image noise measurements were obtained from air adjacent to the lungs [10]. ROIs (diameter, 20 mm; area 314 mm2) were placed in three homogeneous parts of each image and placed in exactly the same location on each selected image. Average SDs from these three ROIs were computed and compared statistically.
Statistical analysis
All statistical analyses were performed using commercially available software: MedCalc version 17.6-64-bit statistical software (Frank Schoonjans, Mariakerke, Belgium). Median values of the subjective scores of the three independent radiologists and the statistical significance of any differences among them from the AD-CT, U-HRCTSHR, and U-HRCTSHR-VOL images were assessed using the Friedman test followed by post-hoc tests. Similarly, data from the objective analysis were also analyzed using the Friedman test followed by post-hoc tests. A p value < 0.05 was considered significant.
Results
Slit phantom evaluation
On AD-CT images, only the 0.35-mm slit could be seen clearly. On U-HRCTSHR, all the 0.35-mm, 0.30-mm, and 0.15-mm slits could be seen. Therefore, the spatial resolution of AD-CT was at least 0.35 mm and that of U-HRCTSHR was at least 0.15 mm (Fig. 2).
Subjective evaluation: abnormal CT findings
The image quality scores for abnormal CT findings on AD-CT, U-HRCTSHR, and U-HRCTSHR-VOL are summarized in Table 1. Both U-HRCTSHR and U-HRCTSHR-VOL abnormal CT finding scores were significantly higher than those of AD-CT (p < 0.0001) (Fig. 3) except for intralobular reticular opacities. For intralobular reticular opacities, AD-CT abnormal CT finding scores were significantly higher than those of U-HRCTSHR and U-HRCTSHR-VOL (p < 0.0014) (Fig. 4).
Subjective evaluation: normal anatomical structures and general aspects of image quality
The image quality scores for normal anatomical structures and general aspects of image quality on AD-CT, U-HRCTSHR, and U-HRCTSHR-VOL are summarized in Table 2. Both U-HRCTSHR and U-HRCTSHR-VOL normal anatomical structure scores for bronchi and vessels were significantly higher than those of AD-CT (p < 0.0001) (Fig. 4). Regarding the general aspects of image quality, both U-HCTSHR and U-HRCTSHR-VOL indicated significantly decreased streak and dark band artifacts with respect to AD-CT (p < 0.0001) (Figs. 3 and 4). The subjective visual noise of U-HRCTSHR-VOL was the lowest of the three groups (p < 0.00001). U-HRCTSHR and U-HRCTSHR-VOL overall image quality scores were significantly higher than those of AD-CT and almost equal to those of U-HRCTN (p < 0.0001).
Quantitative image noise measurements
Quantitative noise values (mean ± SD) on CT images were as follows: AD-CT (16.03 ± 5.17), U-HRCTN (15.14 ± 5.49), U-HRCTSHR (30.41 ± 4.65), and U-HRCTSHR-VOL (26.84 ± 5.12). Quantitative noise values were significantly higher in the following order: U-HRCTSHR, U-HRCTSHR-VOL, AD-CT, and U-HRCTN (p < 0.0001).
Discussion
This study showed that ultra-high-resolution CT (U-HRCTSHR and U-HRCTSHR-VOL) significantly improved the visualization of normal and abnormal CT findings compared with AD-CT, except for intralobular reticular opacities and reduced streak and dark band artifacts. U-HRCTSHR and U-HRCTSHR-VOL provided significantly higher overall image quality than AD-CT. In particular, U-HRCTSHR-VOL was less noisy than U-HRCTSHR. The present study is the first to evaluate the image quality of U-HRCT images compared with AD-CT. The use of U-HRCT might enhance image quality by improving spatial resolution, resulting in provision of more detailed information of lung anatomy and pathology. However, our results might be speculative from a clinical point of view, as all data in the present study originated from an ex-vivo phantom study employing explanted lungs imaged free in air. Further analyses are needed to validate our results by using larger cohorts including various diseases in a clinical practice.
The recent development of U-HRCT technology (i.e., 0.25 × 0.25 mm detector element size, a detector with 1792 channels in 160 rows, and 0.4 × 0.5 mm minimum focus size of the X-ray tube) improve spatial resolution in both in-plane and body-axis directions. In the present evaluation of a slit phantom using a reconstruction FOV of 20 mm, the spatial resolution of U-HRCT (at least 0.15 mm) was at least two times higher than that of AD-CT (at least 0.35 mm). In the evaluation of cadaveric human lungs using a reconstruction FOV of 160 mm, the pixel sizes in 512 × 512 (AD-CT) and 1024 × 1024 matrices (U-HRCTSHR and U-HRCTSHR-VOL) were 0.313 mm and 0.156 mm, respectively. In this study, ADCT could resolve up to 0.35 mm in spatial resolution (0.313-mm pixel size < 0.35-mm maximum spatial resolution of AD-CT). On the other hand, U-HRCT could resolve up to 0.156 mm in spatial resolution (0.156-mm pixel size > 0.15-mm maximum spatial resolution of U-HRCT). Therefore, it is important to understand the limit of spatial resolution in each CT device and confirm the optimal conditions to secure the spatial resolution in a clinical setting.
Although spatial resolution depends on the matrix size of the reconstructed images, it can never be higher than the maximum spatial resolution of the CT device itself. U-HRCT makes it possible to reconstruct images with matrixes larger than 512 × 512, which is common nowadays [11]. By using a larger matrix and reducing the pixel size, U-HRCT can provide higher spatial resolution for the same FOV size. However, it is important to select a matrix size that is suitable for the intrinsic resolution of the device, determined by the focus size and the detector element size. Further studies of U-HRCT are needed to examine the effect of the matrix size on image quality.
In our evaluation of abnormal CT findings in cadaveric human lungs, both U-HRCTSHR and U-HRCTSHR-VOL significantly improved the abnormal CT findings (ground-glass opacity, consolidation, emphysema, faint and solid nodules, interlobular septal thickening, bronchiectasis, honeycombing) compared with AD-CT. A possible reason why these abnormal findings were more conspicuous in U-HRCT could be the increased spatial resolution of the U-HRCT device. Regarding intralobular reticular opacities, however, visual score values for AD-CT were significantly higher than for U-HRCTSHR and U-HRCTSHR-VOL. In general, intralobular reticular opacities refer to the appearance on HRCT of scattered or diffuse ground-glass attenuation with superimposed interlobular septal thickening and intralobular lines [12,13,14]. This CT finding is due to interstitial pulmonary abnormalities and/or alveolar abnormalities [12, 15,16,17]. We speculate some of the reasons could be the superior spatial resolution of U-HRCT enables visualizing the fine structures around the interlobular septum, resulting in the relative blurring of linear shadows in a case of images including two kinds of abnormal CT findings such as intralobular reticular opacities. In other words, fine shadows are recognized as ground-glass attenuation because of a partial volume effect on AD-CT due to an inferior spatial resolution. As a result, interlobular septal thickening might be relatively conspicuous compared with the surrounding ground-glass attenuation. Even in those cases that showed the same CT findings as on AD-CT, the higher spatial resolution of U-HRCT might provide further information on the origin of these CT findings. In the future, it will be necessary to correlate the CT findings in various diseases with pathological specimens.
In our evaluation of normal anatomical structures and artifacts in cadaveric human lungs, both U-HRCTSHR and U-HRCTSHR-VOL significantly improved the visualization of normal anatomical structures such as bronchi and vessels and reduced streak and dark band artifacts compared with AD-CT. In the case of abnormal CT findings, the higher spatial resolution produced by the U-HRCT device can help better visualize thin linear opacities such as bronchi and vessels. U-HRCT might be able to reduce streak artifacts because the 1792 channels of the detector element affect the resolution of the X-Y plane enabling more precise sampling [18]. Moreover, the frequency range of the reconstruction algorithm is doubled in U-HRCT as the number of channels is twice that of AD-CT. Therefore, it is not necessary to forcibly emphasize the high spatial frequency region as is done in AD-CT, resulting in almost no dark band artifacts caused by an undershoot.
Regarding image noise, quantitative noise values were significantly higher in the following order: U-HRCTSHR, U-HRCTSHR-VOL, and AD-CT. The subjective visual noise of U-HRCTSHR-VOL, however, was the lowest. This might be due to the visual effects associated with the overall higher image quality of U-HRCTSHR-VOL. In this study, AIDR3D, a hybrid iterative reconstruction method, was used for reducing image noise. Previous papers have shown that model-based iterative reconstruction imaging could provide higher image quality with lower noise and artifacts [19, 20]. In the future, the combined use of model-based iterative reconstruction and U-HRCT could possibly result in even higher image quality. As a whole, U-HRCTSHR and U-HRCTSHR-VOL produced a higher overall image quality than AD-CT, almost equal to U-HRCTN, by precisely delineating fine and/or thin structures and reducing artifacts. U-HRCTSHR-VOL is less noisy than U-HRCTSHR. Regarding the improvements of spatial resolution, Fischbach et al. [21] demonstrated that thin section images enhanced resolution, decreased volume averaging from slice to slice, and resulted in an improvement of small nodule detection, confidence levels, and interobserver agreement. Coche et al. [22] demonstrated that enhanced multislice spiral CT with thin collimation could be used to analyze the subsegmental pulmonary arteries precisely and might identify even more distal pulmonary arteries. Yoshioka et al. [23] demonstrated that U-HRCT with 0.25-mm slices significantly improved the visualization of the artery of Adamkiewicz compared with 0.5-mm slices. Therefore, in the future, the improvement of spatial resolution on U-HRCT might have the possibility to lead to diagnostic imaging advances in the lungs. Simultaneously, it might be also important to investigate how detailed CT findings will affect the patient's outcome.
There are several limitations to the study. First, this study included only a small number of cases with a few limited CT findings. Second, evaluations of the influence of absorption and scattering in the human thorax on image quality were lacking. No influence of motion artifacts on image quality was evaluated because of the use of cadaveric human lungs. Therefore, in the future, it will be necessary to investigate how these factors influence the image quality of U-HRCT. Third, image quality was evaluated using CT devices manufactured by a single company. Presently, however, there are no CT devices that offer a similar performance as the one used in this study. In the future, we expect that U-HRCT devices developed by other companies will be clinically available. Fourth, regarding the slice position of CT images, we made the utmost effort to get the same cross section images from the different CT devices. However, we could not get exactly the same images. Fifth, the maximum matrix size in this study was 1024, and further analyses are needed to assess the effect of various matrix sizes on the image quality of U-HRCT. Sixth, there was a potential source of error concerning the radiation exposure. Radiation exposure of the volume mode in terms of CTDIvol was about 15% less than the other acquisition modes. Although the maximum effort was made so that the CTDIvol values would be almost equivalent among the acquisition settings, the tube current could only be adjusted by 10-mA increments on each CT device (i.e., AD-CT, U-HRCT). Ideally, image noise should be evaluated with exactly the same radiation exposure. Moreover, the radiation dose with CTDIvol higher than 20 mGy used in cadaveric human lungs without chest walls might be high and could not be applied with a similar size-specific dose estimation to humans. In a practical setting, evaluations of lung image quality on U-HRCT is needed under the appropriate radiation dose. Seventh, although we evaluated CT findings in pathologically diagnosed cadaveric human lungs, no detailed correlations of CT findings with pathological specimens were assessed. Pathological correlation would be needed to investigate small-size CT findings, including intralobular reticular opacities, in the future. Finally, regarding the 11 cadaveric human lungs, they were specimens that had been stored in our institution for a long time. Although the 11 lungs were inflated and fixed by the Heitzman method and were diagnosed by a pathologist, the details (i.e., type of imaging technique, acquisition, and reading procedure) were unknown. We could not consider the influence of the specimen fixation method and preservation condition on the pathological diagnosis. At least, however, the conditions of cadaveric human lungs at the time of imaging were the same because their image data were acquired on both AD-CT and U-HRCT devices around almost the same time.
In conclusion, U-HRCT (U-HRCTSHR and U-HRCTSHR-VOL) can provide higher image quality than AD-CT by improving the spatial resolution and reducing artifacts. U-HRCTSHR-VOL is also more advantageous concerning noise than U-HRCTSHR. U-HRCT may provide more detailed information for lung anatomy and pathology by clearly delineating CT findings (e.g., vessels, bronchi, ground-glass opacity, consolidation, emphysema, faint and solid nodules, interlobular septal thickening, bronchiectasis, and honeycombing).
Abbreviations
- AD-CT:
-
Conventional area detector computed tomography
- ADIR 3D:
-
Adaptive iterative dose reduction in three dimensions
- CT:
-
Computed tomography
- CTDIvol:
-
Volumetric computed tomography dose index
- HU:
-
Hounsfield units
- MDCT:
-
Multidetector row computed tomography
- U-HRCT:
-
Ultra-high-resolution computed tomography
- U-HRCTN :
-
Ultra-high-resolution computed tomography with normal mode
- U-HRCTSHR-VOL :
-
Ultra-high-resolution computed tomography with volume mode
- U-HRCTSHR :
-
Ultra-high-resolution computed tomography with super-high-resolution mode
References
Hounsfield GN (1973) Computerized transverse axial scanning (tomography). 1. Description of system. Br J Radiol 46:1016–1022
Hu H (1999) Multi-slice helical CT: scan and reconstruction. Med Phys 26:5–18
Hurlock GS, Higashino H, Mochizuki T (2009) History of cardiac computed tomography: single to 320-detector row multislice computed tomography. Int J Cardiovascular Imaging 25:31–42
Choi SI, George RT, Schuleri KH et al (2009) Recent developments in wide-detector cardiac computed tomography. Int J Cardiovascular Imaging 25:23–29
Yanagawa M, Tomiyama N, Honda O et al (2010) Multidetector CT of the lung: image quality with garnet-based detectors. Radiology 255:944–954
Hara T, Urikura A, Ichikawa K et al (2016) Temporal resolution measurement of 128-slice dual source and 320-row area detector computed tomography scanners in helical acquisition mode using the impulse method. Phys Med 32:625–630
Imai Y, Nukui M, Ishihara Y et al (2009) Development and performance evaluation of an experimental fine pitch detector multislice CT scanner. Med Phys 36:1120–1127
Kakinuma R, Moriyama N, Muramatsu Y et al (2015) Ultra-high-resolution computed tomography of the lung: image quality of a prototype scanner. PLoS One 10:e0137165
Markarian B, Dailey ET (1993) In: Groskin SA (ed) Preparation of inflated lung specimens. In Heitzman’s The lung: radiologic-pathologic correlations, 3rd ed. Mosby, St. Louis, pp 4–12
Boehm T, Willmann JK, Hilfiker PR et al (2003) Thin-section CT of the lung: dose electrocardiographic triggering influence diagnosis? Radiology 229:483–491
Goldman LW (2007) Principles of CT and CT technology. J Nucl Med Technol 35:115–128
Johkoh T, Itoh H, Müller NL et al (1999) Crazy-paving appearance at thin-section CT: spectrum of disease and pathologic findings. Radiology 211:155–160
Rossi SE, Erasmus JJ, Volpacchio M et al (2003) “Crazy-paving” pattern at thin-section CT of the lungs: radiologic-pathologic overview. Radiographics 23:1509–1519
Frazier AA, Franks TJ, Cooke EO et al (2008) From the archives of the AFIP: pulmonary alveolar proteinosis. Radiographics 28:883–899
Munk PL, Müller NL, Miller RR, Ostrow DN (1988) Pulmonary lymphangitic carcinomatosis: CT and pathologic findings. Radiology 166:705–709
Naidich DP, Zerhouni EA, Hutchins GM, Genieser NB, McCauley DI, Siegelman SS (1985) Computed tomography of the pulmonary parenchyma. Part 1: Distal air-space disease. J Thorac Imaging 1:39–53
Leung AN, Miller RR, Müller NL (1993) Parenchymal opacification in chronic infiltrative lung diseases: CT-pathologic correlation. Radiology 188:209–214
Richard WW, Muller NL, Naidich DP (2015) High-resolution CT of the lung, fifth edition. Chapter 1. Technical aspects of high-resolution CT. Wolters Kuwer. p2-46,
Yamada Y, Jinzaki M, Tanami Y et al (2012) Model-based iterative reconstruction technique for ultralow-dose computed tomography of the lung: a pilot study. Invest Radiol 47:482–489
Yanagawa M, Gyobu T, Leung AN et al (2014) Ultra-low-dose CT of the lung: effect of iterative reconstruction techniques on image quality. Acad Radiol 21:695–703
Fischbach F, Knollmann F, Griesshaber V, Freund T, Akkol E, Felix R (2003) Detection of pulmonary nodules by multislice computed tomography: improved detection rate with reduced slice thickness. Eur Radiol 13:2378–2383
Coche E, Pawlak S, Dechambre S, Maldague B (2003) Peripheral pulmonary arteries:identification at multi-slice spiral CT with 3D reconstruction. Eur Radiol 13:815–822
Yoshioka K, Tanaka R, Takagi H et al (2017) Ultra-high-resolution CT angiography of the artery of Adamkiewicz: a feasibility study. Neuroradiology. https://doi.org/10.1007/s00234-017-1927-7
Acknowledgements
We thank Mr. Yuya Ito of Canon Medical Systems Corp., Otawara, Japan for his help with scanning the CT phantoms.
Funding
Noriyuki Tomiyama received a research grant from Canon Medical Systems Corp.
The other authors state that they have not received any funding for this work.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Guarantor
The scientific guarantor of this publication is Noriyuki Tomiyama.
Conflict of interest
Noriyuki Tomiyama received a research grant from Canon Medical Systems Corp., formerly Toshiba Medical Systems. This work was technically supported by Canon Medical Systems Corp.
Masahiro Yanagawa, Akinori Hata, Osamu Honda, Noriko Kikuchi, and Tomo Miyata have no conflict of interest related to this study.
Statistics and biometry
No complex statistical methods were necessary for this paper.
Informed consent
Written informed consent was waived by the Institutional Review Board.
Ethical approval
Institutional Review Board approval was obtained.
Study subjects or cohorts overlap
Some study subjects or cohorts were previously reported in Radiology 2010; 255:944-954 because cadaveric lungs stored in our institution were used in this study.
Methodology
• prospective
• experimental
• performed at one institution
Electronic supplementary material
ESM 1
(PNG 16.6 kb)
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
About this article
Cite this article
Yanagawa, M., Hata, A., Honda, O. et al. Subjective and objective comparisons of image quality between ultra-high-resolution CT and conventional area detector CT in phantoms and cadaveric human lungs. Eur Radiol 28, 5060–5068 (2018). https://doi.org/10.1007/s00330-018-5491-2
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00330-018-5491-2