Abstract
Introduction
Traditional open reduction and internal fixation (ORIF) of extra-articular distal humerus fractures has a risk of iatrogenic radial nerve injury, extensive soft tissue stripping, and long incision scar. We performed an antero-lateral minimally invasive plate osteosynthesis (MIPO) technique with the radial nerve exploration for distal-third diaphyseal fractures of the humerus and evaluated clinical and radiographic outcomes through this respective study.
Methods
From April 2010 to June 2016, 28 cases of extra-articular distal-third diaphyseal fractures were treated with an antero-lateral MIPO procedure. Patient demographics, Disabilities of the Arm, Shoulder and Hand (DASH) Score, Mayo Elbow Performance (MEP) Score, elbow range of motion, scars and post-operative complications were recorded and analyzed.
Results
All fractures were united with a mean time of 3.5 months. One patient exhibited delayed union (3.6%). The mean DASH Score was 6.6, and all patients had excellent or good MEP Score values. The average scar length was 6.8 cm, and the shortest was 4.5 cm.
Conclusions
The MIPO technique via an antero-lateral approach for extra-articular distal-third diaphyseal fractures of the humerus results in satisfactory clinical outcomes.
Level of evidence
Level IV, case series, treatment study.
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Introduction
Extra-articular distal-third fractures comprise 16% of humerus diaphyseal fractures [1], for which the treatment has some challenges, with ongoing debate. Non-operative treatment with a functional brace has a high rate of union and good function [2]. However, the disadvantages appear to be unavoidable and include a long immobilization time, malunion due to difficulty in controlling fracture alignment, elbow stiffness, and possible radial nerve injury during closed reduction [2, 3]. To restore alignment and achieve stable fixation for early elbow range of motion (ROM), some authors advocate managing these fractures surgically with open reduction and internal fixation (ORIF) [4, 5]. Posterior and lateral surgical approaches are more often used, though there is an associated risk of iatrogenic radial nerve injury due to the manipulation of nerve, extensive soft tissue stripping, and long incision scar. In recent years, minimally invasive plate osteosynthesis (MIPO) has gained popularity with satisfactory clinical outcomes in the treatment of middle diaphyseal humerus fractures [6, 7]. Regardless, it is not considered safe for distal third humeral fractures without the radial nerve exploration. Therefore, we performed an antero-lateral MIPO technique with the radial nerve exploration using a 3.5-mm universal locking system (ULS, Zimmer, Warsaw, Indiana, USA) for distal-third diaphyseal fractures of the humerus. The purpose of this retrospective study was to examine the clinical outcomes of this MIPO technique based on clinical and radiologic records.
Materials and methods
Our retrospective study was approved by the Institutional Review Board. From April 2010 and June 2016, 78 cases of distal-third diaphyseal fractures of the humerus were treated in our department. Of these, 28 were treated with an antero-lateral MIPO procedure using a 3.5-mm ULS. The inclusion criteria were: (1) age ≥ 18 years, (2) closed fracture or grade I or II open fracture, (3) failure of closed reduction or intolerance to the long time immobilization. Pathologic fractures, grade III open fractures, age < 18 years and patients treated with non-operation or ORIF were excluded.
The patient demographics recorded included sex, age, side, injury cause, and complications. The fracture pattern was determined according to AO Foundation and Orthopedic Trauma Association (AO/OTA) classification. Intra-operative records were reviewed with regard to the operation time and distal screw number. During the follow-up period, Disabilities of the Arm, Shoulder, and Hand (DASH) Score, Mayo Elbow Performance (MEP) Score, elbow ROM, scars and post-operative complications (iatrogenic radial nerve injury, nonunion, delay union, infection, implant failure) were recorded and analyzed for clinical results.
Surgical procedure
The operations in this series were performed under general anaesthesia by the same surgeon at a mean of 3.2 days (range, 1–12 days) after injury. Each patient was placed in the supine position on a radiolucent operating table with the injured arm in a position of 90° abduction. The surgeon was on the cephalic side. The incision was approximately 6–8 cm long and made at the fracture site on the anterior-lateral forearm. The radial nerve was exposed between the brachialis and brachioradialis muscles and identified to ensure the safety of the operation. The brachialis was split parallel with its fibre between the middle third and lateral third, and the fracture site was defined. The fracture fragments were reduced under direct vision and fixed preliminarily with lag screws. A sub-muscular extraperiostal tunnel was generated between the brachialis muscle and the periosteum using a periosteal elevator. A long 3.5-mm locking compression plate (ULS, Zimmer Inc., Warsaw, IN; 10–14 holes) was preflexed to fit the anterior face of the humerus, inserted via the incision and placed proximally across the fracture. According to the fracture type, the distal end of the plate was positioned on the long side of both columns, either the medial or the lateral, to ensure distal fixation of at least two bicortical screws. After the two or three distal screws were fixed directly, the location of the proximal screw was set by the target device of the ULS, and a 0.5-cm incision was created for screw fixation. The sleeve was placed appropriately with the blunt dissection of the trocar. Stretching the surrounding skin, three proximal screws were safely fixed through the small hole with the protection of the sleeve. Successful fracture reduction and proper positioning of the plate and screws were confirmed under fluoroscopic guidance. Elbow flexion without block was confirmed. The wound was closed, and a drainage tube was positioned through the proximal small hole. No external immobilization was used (Fig. 1).
To avoid haematoma formation, drainage was maintained for one to two days after the surgery. After removal of the drainage tube, the patient was instructed to begin ROM of the elbow and shoulder. Daily activities and light manual labour were gradually resumed. All patients were followed post-operatively with clinical and radiographic examinations at four-week intervals.
Results
Our series (Table 1) included 12 males and 16 females with a mean age of 30.8 years (range, 18–71 years). All of the fractures were unilateral. The dominant arm was injured in 11 patients (39.3%). The causes of injury were falls in 13 patients (46.4%), car accidents in nine (32.1%), arm wrestling in three (10.7%), throwing in two (7.1%), and industrial accidents in one (3.6%). Five patients (17.9%) presented with pre-operative radial nerve palsy and five with multiple fractures. According to AO classification, all fractures were grouped as follows: A1 (10 cases, 35.7%), A3 (3 cases, 10.7%), B1 (10 cases, 35.7%), B2 (3 cases, 10.7%), C1 (2 cases, 7.1%).
The patients were followed for a mean duration of 21.6 months (range, 12–36 months). The mean operation time was 118 (SD ± 29.5) minutes. All of the fractures were united, with a mean healing time of 3.5 (SD ± 1.17) months. One patient exhibited delayed union (3.6%), with a union time of nine months. No nonunion, iatrogenic neuropraxia, or implant failure occurred. The five patients with pre-operative radial nerve palsy recovered after a mean duration of 8.7 (SD ± 3.9) weeks. Elbow function was evaluated post-operatively at three months, and the average ROM was 135.18° (SD ± 10.76), ranging from 110° to 150°. The mean DASH Score was 6.6, ranging from 0 to 24.2. For the MEP Score, 27 patients had excellent values (96.4%), and one had a good value (3.6%); no patients had fair or poor values. The average MEP Score was 96.6, ranging from 85 to 100. The average scar length was 6.8 (SD ± 0.98) cm, and the shortest and longest scars were 4.5 cm and 8 cm, respectively (Fig. 2).
Discussion
The main goal of treatment of extra-articular distal humerus fractures is to restore alignment and achieve stable fixation to allow for early elbow ROM, which is crucial for a good functional outcome [4]. However, it is difficult to perform nail osteosynthesis in distal-third fractures because of the short distal fragment and the narrow medullary canal. The current literature suggests that plate and screw fixation via a posterior or lateral approach is a reliable and preferred technique for the surgical treatment of extra-articular fractures of the humerus [4, 5, 8,9,10,11,12,13]. Although a retrospective study of plate osteosynthesis via the anterior approach was reported by Kim et al., this series contained only throwing fractures [14]. In general, the antero-lateral approach is safely applied in most proximal and middle humerus fractures, whereas it is difficult to obtain sufficient fixation at the distal fragment in distal humerus fractures. Our series contained various causes of injury, ages and AO fracture types. For all patients, the operation was performed via the antero-lateral approach, and their fractures healed with satisfactory functional and radiographic results. There were no implant-related complications or iatrogenic radial nerve injury in this series. Our antero-lateral approach of the MIPO technique shows adequate fixation results, with minimal interference to the radial nerve.
Dual plating or a large of number of screws at the distal fragment (LCP metaphyseal plate and extra-articular distal humerus plate) has been suggested for security fixation in distal-third fractures of the humerus [4, 5, 12, 13, 15]. In a multi-centered retrospective study, Meloy et al. compared dual-columnar plating to single plating of extra-articular distal humerus fractures. These authors found that patients treated with single-column plating had similar union rates and alignment as dual-column plating, but with significantly better ROM and fewer complications [16]. Compared with other reports of posterior and lateral approaches, we inserted only two or three locking screws at the distal fragment via the anterior-lateral approach. It can be argued that the use of only two screws might compromise the stability of fixation, especially in elderly patients with poor bone quality and in highly comminuted fractures. Nonetheless, in our series, excellent results of fracture union and arm function without external immobilization postoperatively were achieved for one 71-year-old patient and two patients with C1 fractures. Based on a cadaver study of the osteoporotic humeral shaft, Hak et al. showed that two locking screws per segment are sufficient and that the addition of a third screw in the locked plate construct did not add to mechanical stability for axial loading, bending, or torsion [17]. Fixation of more screws is still an effective method of avoiding the complication of implant failure. Thus, to overcome the limitation of fewer screws, anatomic reduction with lag screws and a long locking compression plate were managed in all patients, as some studies have described that solid screws can increase construct stability dramatically [18] and that bending strength in long bone fractures can be augmented by increased plate length and bridge length [19, 20].
Iatrogenic radial nerve palsy is common in the treatment of distal-third fractures of the humerus. Claessen et al. analyzed 325 patients with diaphyseal humerus fracture who underwent operative treatment and found that the surgical approach was associated with iatrogenic radial nerve palsy. This complication occurred in 22% of patients treated via a lateral approach, 11% via a posterior approach, and 4% via an anterior-lateral approach [21]. When using the posterior and lateral approaches, the radial nerve must be identified and mobilized with a long segment, allowing the plate to be placed under the nerve. With an appropriate antero-lateral approach, the radial nerve can readily be exposed between the brachialis and brachioradialis muscles and be protected in the muscle fibre during the procedure. In addition, the plate can be placed in a relatively safe position away from the radial nerve with direct visualization. Implant irritation is another possible complication of the operation using the posterior approach, resulting in pain and reoperation because of the thin soft tissue covering [4, 12].
The MIPO technique for distal-third humerus fractures has recently been reported [22,23,24]. The anterior MIPO technique for mid-distal humeral shaft fractures was described by An et al. and compared with conventional open reduction [22]. In their series, the radial nerve was not exposed during the operative procedures. Livani et al. performed ultrasonographic measurement of the distance between the radial nerve and the implant material with the anterior MIPO procedure and revealed that the nerve is quite close to the plate, especially in the distal third fractures (mean 4.0 mm) [25]. Therefore, percutaneous plate insertion is a dangerous procedure without the radial nerve exploration, for the high risk of nerve entrapment. Zogbi et al. described a MIPO technique with the lateral approach, though the iatrogenic radial nerve palsy rate was as high as 42.9% (3/7), even though the radial nerve was visualized during the surgery [23]. Gallucci reported posterior MIPO for distal-third humeral shaft fractures, with a 5% (1/21) rate of iatrogenic radial nerve palsy and a 76.2% (16/21) rate of varus deformity [24]. In general, MIPO is not considered suitable for fractures in the distal-third humerus due to the risk of radial nerve injury and deformity caused by indirect reduction [15]. In our procedure, the reduction of fractures and radial nerve exploration can be achieved in a minimal incision, and fixation of proximal screws can be safely managed by the target device through a small hole. In our series, the average scar length was 6.8 cm, and the shortest was 4.5 cm.
The limitations of this study include the relatively small sample size and the few elderly and comminuted fracture patients. In addition, we did not have a control group with which to compare the effectiveness of our technique.
Conclusion
For extra-articular distal humerus fractures, a MIPO operation via the anterior-lateral approach results in satisfactory clinical and radiographic outcomes. This approach may be considered a surgical option, offering advantages of sufficient fixation, fewer complications, less invasion and scarring, and excellent functional results.
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It is certified that the submission by the author Wei Zhao, Department of Orthopedics, First Affiliated Hospital Of Dalian Medical University (approval number: LCKY2016–44), is in accordance with institutional medical ethics requirements. After the review, the hospital medical ethics committee agreed with the report.
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Zhao, W., Qu, W., Fu, C. et al. Antero-lateral minimally invasive plate osteosynthesis (MIPO) with the radial nerve exploration for extra-articular distal-third diaphyseal fractures of the humerus. International Orthopaedics (SICOT) 41, 1757–1762 (2017). https://doi.org/10.1007/s00264-017-3514-2
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DOI: https://doi.org/10.1007/s00264-017-3514-2