Abstract
Introduction
Hybrid magnetic resonance (MR) linear accelerators (MR-Linacs) for radiotherapy allow for the visualization and tracking of moving target volumes during the entire treatment. This makes gated treatments possible, decreasing the irradiated volumes and thus sparing healthy tissue from unnecessary radiation dose. Conventionally, tumors that are subject to respiration motion are treated by irradiating the entire area of potential target presence (internal target volume, ITV). This study presents three patient cases (lung, adrenal gland, and liver tumors) treated with gated MR-guided radiotherapy and compares the treatment plans retrospectively with conventional ITV plans.
Materials and methods
The gross tumor volume was delineated on MR and computed tomography (CT) images of the patients, and MR-Linac treatment plans were generated using additional clinical and planning target volume margins. The motion of the gross tumor volume was evaluated on two-dimensional cine-MRI images during the entire MR-Linac treatment. Based on the motion analysis, standard ITV-based plans were retrospectively created and compared by means of irradiated target volumes and dose–volume parameters.
Results
For the MR-Linac plans, the irradiated treatment volumes were reduced by an average of 62% across the three cases, and for one case the ITV-based target volume would have overlapped with a critical organ. Target volume coverage was much better and the lung and adrenal MR-Linac plans revealed superior sparing of the organs at risks thanks to gated treatments.
Conclusion
Dosimetrically beneficial treatment plans with promising clinical outcomes can be applied when using gated MR-guided radiotherapy. Future studies will reveal which patients will benefit most from this technique. To utilize the full potential of online adaptive, individualized MR-guided therapy, the close collaboration of radio-oncology and radiology is needed.
Zusammenfassung
Hintergrund
Hybrid-Magnetresonanz(MR)-Linearakzeleratoren (MR-Linacs) für die Strahlentherapie ermöglichen die Visualisierung und Verfolgung beweglicher Zielvolumina während der gesamten Behandlung. Das erlaubt atemgesteuerte Therapien, vermindert die bestrahlten Volumina und schont somit gesundes Gewebe vor unnötiger Strahlendosis. Konventionell werden Tumoren, die der Atembewegung ausgesetzt sind, durch Bestrahlung des gesamten Bereichs behandelt, in dem sich das Ziel befinden kann („internal target volume“, ITV). In der vorliegenden Studie werden 3 Fälle vorgestellt (Lungen‑, Nebennieren- und Lebertumor), die mittels atemgesteuerter MR-geführter Strahlentherapie behandelt wurden, dabei werden die Behandlungsplanungen retrospektiv mit konventionellen ITV-Planungen verglichen.
Material und Methoden
Das makroskopische Tumorvolumen wurde auf MRT- und Computertomographie(CT)-Aufnahmen der Patienten abgegrenzt, und die jeweilige MR-Linac-Behandlungsplanung wurde unter Berücksichtigung zusätzlicher klinischer und Planungszielvolumenmargen erstellt. Die Bewegung des makroskopischen Tumorvolumens wurde auf zweidimensionalen CINE-MRT-Bildern während der gesamten MR-Linac-Behandlung beurteilt. Auf Grundlage der Bewegungsanalyse wurden retrospektiv Standard-ITV-Planungen erstellt und anhand von bestrahlten Zielvolumina und Dosis-Volumen-Parametern verglichen.
Ergebnisse
Für die jeweilige MR-Linac-Planung wurde in den 3 Fällen das bestrahlte Behandlungsvolumen um durchschnittlich 62% reduziert, und in einem Fall hätte das ITV-basierte Zielvolumen sich mit einem kritischen Organ überschnitten. Die Zielvolumenabdeckung war viel besser und die MR-Linac-Planung für die Lunge und die Nebenniere wiesen eine deutlichere Schonung der gefährdeten Organe durch die atemgesteuerte Behandlung auf.
Schlussfolgerung
Eine dosimetrisch vorteilhafte Behandlungsplanung mit vielversprechenden klinischen Ergebnissen kann eingesetzt werden, wenn die atemgesteuerte MR-geführte Strahlentherapie angewandt wird. Zukünftige Studien werden zeigen, welche Patienten den größten Vorteil durch diese Technik haben. Um das ganze Potenzial der online adaptiven, individualisierten MR-geführten Therapie zu nutzen, ist eine enge Zusammenarbeit zwischen der Radioonkologie und der Radiologie erforderlich.
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Introduction
During the past few decades, significant technical and methodological innovations have paved the way for highly precise and focused radiotherapy delivery. On the one hand, modern imaging technologies such as computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET) have become essential techniques for diagnostic evaluation and treatment planning in radiation therapy, allowing for accurate differentiation between cancerous and healthy tissue. Additionally, the integration of various imaging modalities directly into linear accelerators has enabled daily monitoring of patient positioning, tumor position, and alterations in patient anatomy.
Today, X‑ray-based image guidance has become a widely used standard, as it is established in nearly all radiotherapy units, mostly by means of integrated cone-beam and megavoltage fan-beam CT (CBCT and MVCT). However, besides exposing the patient to additional radiation, CBCT and MVCT imaging is limited with respect to the achievable soft-tissue contrast, practically only allowing image guidance based on bony structures. On the other hand, MRI offers excellent soft-tissue contrast for the precise identification of target volume and immediate detection of inter- and intra-fractional changes of the tumor and adjacent organs at risk. Since the direct integration of MRI into medical linear accelerators has been challenging for many years, the first studies on MR-guided radiotherapy (MRgRT) focused on offline solutions [1,2,3]. Only recently have hybrid machines that combine MRI scanners with radiotherapy delivery systems become clinically available, enabling online MRgRT [4, 5]. Two hybrid devices are currently in clinical use: The ViewRay (Mountain View, CA, USA) MRIdian Linac system combines a split-bore 0.35‑T MRI scanner with a radiation gantry including the linear accelerator (6 MV; [6]), while the Elekta (Stockholm, Sweden) Unity MR-Linac is composed of a 1.5‑T MRI scanner and a ring-based gantry containing a 7-MV linear accelerator [7, 8].
The new hybrid MR-Linac systems not only offer superior anatomical 3D imaging for precise delineation of the tumor as well as immediate detection of inter-fractional changes, but also provide real-time information by cine MRI, allowing for constant monitoring of tumor volume and nearby critical structures during the entire treatment session [7, 9]. Compared with conventional radiotherapy techniques, safety margins and hence the irradiated volume can be decreased, thereby reducing the risk of toxicity. In general, safety margins are applied in radiotherapy to ensure optimal dose coverage of the target volume besides uncertainties during planning, setup, or treatment [10]. MR-guided radiotherapy of smaller, clearly visible target volumes further has the potential of dose escalation in the tumor volume for increasing local control. Highly encouraging initial results have been published for several tumor entities including pancreatic carcinoma, early-stage low-risk breast cancer, prostate cancer as well hepatic and adrenal metastases [11,12,13,14,15,16].
Abdominal organs are subject to movement caused by breathing and positional drifts in the body of several centimeters during irradiation. For CT-guided radiotherapy, clinically established strategies for motion compensation include breath-hold techniques or continuous irradiation in free breathing using an internal target volume (ITV). The ITV concept, which is most widely applied, accounts for tumor movement by incorporating the tumor position into the target volume in all breathing phases, assessed by a 4D CT [17]. Thus, with the ITV concept, the whole area of potential tumor position is irradiated.
By contrast, some MRgRT devices enable gated dose delivery. With MR-guided gating, radiation is only delivered when the tracked tumor is in the right position in the cine MRI, and the treatment beam automatically turns off if the tumor moves outside a specified boundary [9]. The required safety margins and hence treated volumes can thereby be reduced compared with the ITV concept (see Fig. 1).
In this work, we present three clinical examples (lung metastasis, adrenal metastasis, and liver metastasis) for gated radiotherapy based on real-time cine-MRI, as well as a comparison for those cases with retrospectively calculated ITV-based treatment plans.
Material and methods
MR-Linac
The MRIdian Linac that has been in clinical use in our institution since April 2018 provides a “true fast imaging with steady-state precession” (TRUFI) pulse sequence, a type of balanced steady-state free precession sequence (bSSFP), which can be used for volumetric imaging as well as cine imaging [6]. Moreover, navigator-based T1-weighted and T2-weighted images can be acquired in research mode. The clinical TRUFI sequence yields T2-/T1-weighted contrast that highlights fat and water, enabling a straightforward differentiation of organs.
In MRgRT, volumetric imaging is used for treatment planning as well as patient positioning. Moreover, the treatment plan can be adapted online based on the daily patient anatomy while the patient lies on the treatment couch. The volumetric TRUFI can be acquired at the MRIdian Linac with an in-plane resolution of 1.5 mm and slice thicknesses of 1.5 or 3.0 mm. During treatment delivery, sagittal 2D cine-MR images can be acquired at 4 frames/s with 3.5-mm in-plane resolution and with 5‑, 7‑, or 10-mm slice thickness [6]. The cine-MRI is used for real-time tumor tracking and automated beam gating. For tumor tracking, a key frame of the cine-MRI is selected and registered to the volumetric image via deformable image registration. All subsequent cine images are registered to this key frame, which enables tracking of the target structure delineated in the volumetric image [9]. At Heidelberg University Hospital, gated MRgRT is performed with optional live video assistance. A video screen that can be observed by the patient via a mirror is installed at the end of the bore [18]. Patients can follow the position of the target volume in real time and breathe accordingly in order to steer their tumor to the desired position.
Treatment planning
The gross tumor volume (GTV) was delineated on the 3D MR image generated at the MR-Linac, and with the aid of contrast-enhanced CT-images as well as additional diagnostic MRI, if available. An appropriate clinical target volume margin (CTV) was added to account for microscopic infiltration. The resulting CTV was enlarged by 3 mm to form the planning target volume (PTV). In radiotherapy, the target volume, which comprises the macroscopic tumor (GTV) plus the microscopic tumor infiltration (CTV), is enlarged by a further margin to account for uncertainties during planning, setup, or treatment (PTV; [10]). Step-and-shoot intensity-modulated radiotherapy (IMRT) treatment plans for the MR-Linac were generated using the ViewRay treatment planning system based on a Monte Carlo dose calculation algorithm considering the magnetic field. The dose calculation was carried out with a 3-mm dose grid and an uncertainty of 0.5%.
For the ITV approach, comparative plans were calculated using RayStation (Version 8B 8.1.1.8, RaySearch, Stockholm, Sweden) with a collapsed cone dose calculation algorithm for an Elekta Versa HD Linac with 6 MV. Craniocaudal and anteroposterior ITV margins were estimated using the sagittal 2D cine images of the MR-Linac treatments [19], while a lateral margin of 2 mm was assumed in accordance with the literature [20, 21]. For the lung, liver, and adrenal patients, ITV margins of 1.1 cm, 1.7 cm, and 1.75 cm in craniocaudal direction and 0.85 cm, 0.65 cm, and 1.25 cm in anteroposterior direction, respectively, were determined from the real-time cine-MR images recorded during therapy. The comparative plans were generated according to clinical standards used at Heidelberg University Hospital. For the adrenal gland and liver tumor, volumetric-modulated arc therapy (VMAT) plans were created, while a 3D conformal plan was calculated for the lung case. The PTV margin was set to 5 mm for all cases. MR-Linac and ITV-based plans were generated using the same dose prescription and clinical goals for target coverage as well as organ-at-risk (OAR) dose constraints. Of note, in clinical routine treatment, these plans would not have been applied, as PTV coverage had to be reduced due to the proximity of critical radiosensitive OARs. In general, radiotherapy doses would instead have been adjusted and treatment would have been performed with reduced doses.
The treatment plans were compared based on PTV volume, target coverage, and dose–volume parameters of OARs. In order to compare the dose–volume parameters premised on the same calculation basis, the MR-Linac plans were imported into RayStation.
Case presentation and results
Patient cases
To highlight the potential of MRgRT, we evaluated the treatments of three patients treated at the MRIdian Linac at the Department of Radiation Oncology of Heidelberg University Hospital, Germany. All patients have been included in a prospective registry (Heidelberg Medical Faculty Ethics Commission, study ID S‑506/2018).
The first patient (female, age 82) had initially been diagnosed with a large-cell neuroendocrine carcinoma (pT4pN0cM0) of the lung, and had therefore undergone surgical resection of the right lower lobe as well as mediastinal lymphadenectomy 5 years before. A growing lung nodule of the left upper lobe was diagnosed in June 2019. The patient underwent positron-emission tomography (PET) for staging and to rule out further metastases. A biopsy confirmed the diagnosis of a solitary pulmonary metastasis of the initial large-cell neuroendocrine carcinoma. Due to her age and severe pulmonary comorbidities, stereotactic body radiotherapy (SBRT) was recommended as treatment by an interdisciplinary tumor board. The patient was treated at the MRIdian Linac applying gated dose delivery with 8 × 7.5 Gy prescribed to the 80% isodose, as the tumor was located adjacent to the thoracic wall (see Fig. 2a, b). She tolerated the treatment well with only mild toxicity. The CT scans acquired during follow-up (3 and 6 months later) showed excellent treatment response with no signs of pneumonitis and only rare ground-glass opacity (Fig. 2c, d).
The second patient (female, age 50) was diagnosed with locally advanced breast cancer in 2006 and was treated with neoadjuvant chemotherapy, breast-conserving surgery, and adjuvant whole-breast radiotherapy. In 2017, pulmonary, hepatic, and bone metastases were detected and systemic treatment was initiated with fulvestrant/goserelin and palbociclib. In April 2019 progression limited to liver segments II/IV (2.4 cm × 5.6 cm) was diagnosed, and the patient received gated MR-guided radiotherapy with 3 × 15 Gy prescribed to the 65% isodose (Fig. 3a, b). Palbociclib was paused during SBRT. Hepatic SBRT was well tolerated, the patient only suffered from mild nausea and fatigue. Follow-up MRI after 3 and 9 months showed treatment response with a reduction in size and perfusion of the irradiated hepatic metastasis (Fig. 3c, d).
The third patient was diagnosed with a malignant melanoma of the conjunctiva of the left eye in 2014, which had been locally resected, preserving the eye ball. There were multiple recurrences over subsequent years that were treated by resection and systemic therapy with interferon. Due to further relapses, the orbit was exenterated in 2017, followed by adjuvant radiotherapy. In 2018, multiple metastases in the lungs and the liver were diagnosed and treated with nivolumab/ipilimumab. The patient responded well to immunotherapy, but developed progression limited to the left adrenal gland. Therefore, MR-guided SBRT of the left adrenal metastasis was performed with 5 × 10 Gy prescribed to the 80% isodose (Fig. 4a, b). The patient only suffered from mild dyspepsia during treatment. Follow-up CT scans illustrated excellent treatment response with complete remission of the irradiated adrenal gland metastasis after 3 and 6 months (Fig. 4c, d).
The radiotherapy treatment at the MR-Linac was well-tolerated by all patients. Patient acceptance was evaluated through patient-reported outcome questionnaires and revealed a positive or at least tolerable rating of the overall treatment [18].
Plan comparison
The treatment plan parameters of the MR-Linac and ITV-based plans are shown in Table 1. Before a treatment plan is calculated by a physicist, the treating physician defines the clinical objectives for the respective plan, which consist of the dose prescription for the target volume (e.g., the tumor) and the dose constraints for the surrounding radiosensitive OARs. For SBRT, different groups have published certain dose constrains [22,23,24]. The dosimetry parameters for each plan, for target (PTV) coverage and normal tissue doses, are shown in Tables 2, 3 and 4; the planning objectives against which these dosimetric parameters are judged are also shown. Most of the objectives can be rejected if absolutely necessary, although dose to the spinal cord is considered a hard constraint. While the gated MR-Linac treatment plans fulfilled all clinical goals, only one ITV plan met all criteria.
As an ITV encompassing tumor motion during breathing had to be generated for the ITV plans, target volumes (PTV) were 2–3.5 times larger in the ITV plans compared with the MR-Linac plans (see Tables 1, 2 and 3). Therefore, doses to the adjacent OARs were generally higher in the ITV plans than in the MR-Linac plans.
Lung SBRT case
For the lung ITV plan, only 66% of the PTV would have been encompassed by the 60 Gy isodose line, instead of the prescribed 95% (see Table 2; Fig. 5). Moreover, the dose to the heart, thoracic wall, and left lung would have been considerably larger and closer to the prescribed clinical dosimetric constraints compared to the MR-Linac plans, whereas the MR-Linac plan approached the constraints for the maximum dose to esophagus and central respiratory tract.
Liver SBRT case
For the liver case, both plans fulfilled all the clinical objectives, with comparable dose–volume parameter values (see Table 3; Fig. 6). The dose distribution of both treatment plans is depicted in Fig. 6.
Adrenal SBRT case
For the adrenal gland tumor, the PTV of the ITV-based plan overlapped in parts with the stomach, which resulted in a decreased dose coverage of the PTV compared with the MR-Linac plan, in order to meet the stomach dose constraint (see Table 4; Fig. 7). Hence, only 89% of the PTV was encompassed by the 50-Gy isodose. Although all other dose constraints were met in both plans, the dose to the spinal cord was substantially lower in the MR-Linac plan.
Discussion
Magnetic resonance-guided gated stereotactic radiotherapy allows for the application of favorable dosimetric treatment plans for moving tumors by decreasing irradiated volumes, with promising clinical results. It is assumed to be especially beneficial in abdominal or thoracic tumor sites [25,26,27]. For conventional ITV-based treatment plans, irradiated target volumes are considerably larger and may overlap with critical organs, which can either lead to inferior target coverage or higher doses to OARs. For two of the three patients presented here, either less dose coverage of the PTV would have been achieved, or clinically a lower dose prescription would have been chosen if these patients would have been treated with an ITV approach. It should be noted that the ITV margins in this study were derived from the 2D cine-MRI (anterior–posterior and superior–inferior margin) as well as from the literature (lateral margin). Conventionally, they are obtained via 4D CT over several breathing cycles. However, the margins deduced by cine-MRI might be more realistic, since the whole treatment was evaluated instead of a limited number of breathing cycles on 1 day [28, 29]. The lateral movement could not be evaluated on the sagittal cine-MRI data. For most patients and tumor sites, lateral motion is very limited, however.
In contrast to other techniques for respiratory beam gating, using radio-frequency transponders or kV-gated treatment with fiducial markers, MR-guided gating is less invasive and is not accompanied by additional imaging radiation dose. Compared with surface-guided radiotherapy (SGRT), the MR-gated treatment offers increased accuracy, since the irradiated target is directly monitored and no assumption of a correlation between surface and target movement is required. Moreover, additional immobilization devices for abdominal compression, which can be used to minimize motion for ITV-based treatments but at the same time decrease patient comfort, can be omitted.
However, compared with the ITV approach, MR-guided treatments are more time-consuming. To facilitate reproducible breath-holds and thus shorten treatment time, many hospitals, including Heidelberg University Hospital, have installed a video monitor in the treatment room that shows the real-time cine-MR image to the patients, so that they can control the breath-hold by themselves [18, 30, 31]. With this approach, the patients have an active role during the duration of treatment, which is highly appreciated by the majority of patients [18]. In general, for most of the patients a dedicated breathing training is helpful in order to enable an efficient gating duty cycle. Due to the increased treatment time of the gated MR-Linac treatments, the patients have to lie still for at least 30 min in the treatment position. This has to be kept in mind when screening patients for the MR-Linac.
In order to further improve target tracking on the cine-MRI, dedicated contrast agents might be used. Especially for some liver tumors, the GTV cannot be sufficiently discriminated from the surrounding healthy liver in the native TRUFI sequence. Here, contrast agents such as gadoxetate disodium may help to visualize liver tumors [32]. Optimal contrasting of the hepatic lesion is usually detected after 15–20 min and usually persists during gated breath-hold SBRT [32].
The current standard MRI sequence for 3D as well as 2D cine-MR images on the MRIdian Linac is a TRUFI sequence, enabling straightforward delineation of target volumes and OARs. For abdominal and thoracic tumors, short imaging sequences are required to enable imaging in breath-hold without breathing artifacts. Thus, important issues are fast and robust image acquisition as well as geometric fidelity rather than diagnostic image quality. Until recently, only one sequence, namely, the TrueFISP sequence, was available and had to be used for target and OAR delineation at the MRIdian Linac. Together with a recent upgrade, a standard T1- and T2- as well as diffusion-weighted imaging (DWI) sequences are now also available at the MRIdian Linac. However, primary contouring is still only possible on the TrueFISP sequences. Furthermore, rigid as well as deformable registration of diagnostic contrast-enhanced MRI sequences is only achievable on a limited level.
Nevertheless, functional imaging like DWI for biological tumor response monitoring and prediction can be applied during the course of MR-guided treatments [33, 34]. Shaverdian et al. showed that DWI is feasible on a low-field 0.35‑T MR-Linac in order to identify the individual response as well as potential treatment-resistant regions after chemoradiotherapy of rectal cancer [35]. Functional MRI may have potential use for biological dose adaption and dose escalation in the future [36], but further studies, especially on optimal imaging and adaption time points, are still required. Furthermore, MRI may also provide quantitative information about the actual delivered dose and its impact on the tumor as well as on normal tissue, which would allow for dose-compensating strategies and radiobiological modeling of tumor and normal tissue [34].
As MR-guided adaptive radiotherapy is highly personnel-intensive and time-consuming, well-designed clinical trials are needed to identify the patients who benefit most from adaptive MR-guided radiotherapy. We recently published initial treatment experiences reporting a mean treatment time of 40 min for gated breath-hold SBRT, which is much longer compared with standard SBRT treatments of 10–15 min [18]. However, head-to-head comparative studies of CT-guided and MR-guided adaptive radiotherapy applying standard dose and fractionation might not be sufficient to demonstrate the true potential of MR-guided adaptive radiotherapy, since MR-guided adaptive radiotherapy allows for high-dose radiotherapy under circumstances in which treatment would not have been possible with conventional techniques [37].
The ultimate potential of the new MR-guided hybrid devices is immediate online adaptive treatment based on the anatomy of the day [13, 38]. Radiation oncologists are now obliged to re-think the paradigms of total dose determination at the beginning of treatment and equal dose delivery during each single fraction. MR-guided adaptive radiotherapy holds promise in terms of applying the highest tolerated doses every single day depending on the current position of the tumor and the surrounding OARs. If dose escalation is not pursued, superior protection of critical structures from dose spillage is an alternative goal for plan adaptation. Initial studies have already reported mainly dosimetric advantages for online adaptation of MR-guided stereotactic radiotherapy of pancreatic, adrenal, or ultracentral thoracic malignancies among others [11, 13, 39]. However, adaptive treatments further prolong treatment time to at least 45–70 min [30, 40]. Additional results of ongoing clinical studies are eagerly anticipated.
MR-guided radiation therapy enables online treatment plan adaption, options for real-time MR-based automated beam gating, and ultimately daily individualized radiotherapy. A close collaboration between radio-oncology and radiology as well as medical physics is needed to utilize the full potential in order to further improve tumor control and reduce side effects in cancer therapy.
Conclusion
With magnetic resonance (MR)-guided radiotherapy and cine-MR-based beam gating, moving tumors can be treated using smaller irradiated target volumes compared with conventional non-gated techniques. This results in dosimetrically beneficial treatment plans and promising clinical outcomes. Future studies will reveal the true potential of MRI for online biologically adapted radiation therapy and identify which patients will benefit most from this technique.
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J. Hörner-Rieber and S. Klüter received speaker fees and travel reimbursement from ViewRay Inc. J. Hörner-Rieber received travel reimbursement from IntraOP Medical and Elekta Instrument AB. She also received a grant from IntraOP Medical. J. Debus received grants from CRI (The Clinical Research Institute GmbH), View Ray Inc., Accuray International, Accuray Incorporated, RaySearch Laboratories AB, Vision RT limited, Astellas Pharma GmbH, Merck Serono GmbH, AstraZeneca GmbH, Solution Akademie GmbH, Ergomed PLC Surrey Research Park, Siemens Healthcare GmbH, Quintiles GmbH, Pharmaceutical Research Associates GmbH, Boehringer Ingelheim Pharma GmbH Co, PTW-Freiburg Dr. Pychlau GmbH, Nanobiotix A.A., as well as IntraOP Medical. He has a research agreement with ViewRay Inc. and is a member of the Scientific Advisory Board of ViewRay Inc. (Oakwood, OH, USA). C.K. Spindeldreier, P. Hoegen, C. Buchele, C. Rippke, and E. Tonndorf-Martini declare that they have no competing interests.
For this article no studies with human participants or animals were performed by any of the authors. All studies performed were in accordance with the ethical standards indicated in each case.
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The authors C. Katharina Spindeldreier and Sebastian Klüter contributed equally to this article.
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Spindeldreier, C.K., Klüter, S., Hoegen, P. et al. MR-guided radiotherapy of moving targets. Radiologe 61 (Suppl 1), 39–48 (2021). https://doi.org/10.1007/s00117-020-00781-4
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DOI: https://doi.org/10.1007/s00117-020-00781-4