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DEN-Induced Hepatocellular Carcinoma in Animal Model

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Handbook of Animal Models and its Uses in Cancer Research

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Abstract

Cancer is a major cause of death both in developed and developing countries. Among the various types of cancers, primary liver cancer represents about 4% of all cancers worldwide. Hepatocellular carcinoma (HCC) is a histological type of liver cancer; the fact being that the aspects related to the development of hepatocellular carcinoma and its metastasis are not yet known, and here animal models play an important role in diagnosis, prognosis, and treatment strategies of the disease. Animal models also provide an opportunity to explore new treatment strategies. N-nitroso compounds mainly N-diethylnitrosamine (DEN) is a hepatic carcinogen, which is well known to cause liver necrosis. The current review is based on research and review of works on animal models treated with DEN-induced hepatocarcinogenesis. Despite ongoing debate, animal models could provide valuable information about biotransformation of toxicants and how they worsen the damaging effects on DNA and cell proteins that result in the development of cancer. Today, the emergence of various therapies that target the immune system and the tumor microenvironment emphasizes the importance of the host, conditions of chronic inflammation, and fibrosis. Thus, the use of animal models for anti-HCC drug screening will find our best ability to successfully discover new drugs to combat HCC.

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Authors and Affiliations

  1. Department of Zoology, Presidency College, Chennai, India

    K. Sivakumari & S. Rajesh

  2. Department of Medicine, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    P. Janani

Authors
  1. K. Sivakumari
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  2. P. Janani
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  3. S. Rajesh
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Editor information

Editors and Affiliations

  1. Allied Health Sciences, CARE, Chennai, Tamil Nadu, India

    Surajit Pathak

  2. Fac of Allied Health Sciences, CHRI, Chettinad Acad of Res & Education, Kelambakkam, Chennai, Tamil Nadu, India

    Antara Banerjee

  3. AGENTEM, Cukurova University, Adana, Turkey

    Atil Bisgin

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Sivakumari, K., Janani, P., Rajesh, S. (2022). DEN-Induced Hepatocellular Carcinoma in Animal Model. In: Pathak, S., Banerjee, A., Bisgin, A. (eds) Handbook of Animal Models and its Uses in Cancer Research. Springer, Singapore. https://doi.org/10.1007/978-981-19-1282-5_23-1

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  • DOI: https://doi.org/10.1007/978-981-19-1282-5_23-1

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-19-1282-5

  • Online ISBN: 978-981-19-1282-5

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