Zusammenfassung
Der Gastrointestinaltrakt (GIT) ist in seinen Grundfunktionen autonom. Der GIT ist aber sensorisch und motorisch mit dem zentralen Nervensystem (ZNS) verbunden, sodass die gastrointestinalen Grundfunktionen in den Verhaltenskontext eingebunden werden. Besondere Bedeutung haben hier die Warnsysteme, die der Abwehr von Körperschädigungen dienen. Dazu gehören sowohl Spinalnerven, die nozizeptive Reflexe und Schmerzempfindungen auslösen, als auch Vagusafferenzen, die eine Krankheitsreaktion induzieren.
Aus Studien wissen wir, dass psychische und körperliche Vorgänge im GIT eng miteinander verbunden sind, unter anderem über hormonelle Systeme oder das vegetative Nervensystem mit Sympathikus und Parasympathikus. Solche Zusammenhänge werden sichtbar, wenn wir in angstauslösenden Situationen wiederholt zur Toilette müssen oder Bauchschmerzen bekommen. Im Umkehrschluss können körperliche Beschwerden aber auch Ängste auslösen und bei länger anhaltenden Symptomen zu depressiven Verstimmungen führen. Hierbei spielt die Hirn-Darm-Achse eine wichtige Rolle.
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Literatur
Furness, J.B., The enteric nervous system and neurogastroenterology. Nat Rev Gastroenterol Hepatol, 2012. 9(5): p. 286–94.
Sasselli, V., V. Pachnis, and A.J. Burns, The enteric nervous system. Dev Biol, 2012. 366(1): p. 64–73.
J.B., F., The Enteric Nervous System. 2006, Oxford: Wiley-Blackwell.
Lazarus, R.S. and S. Folkman, Stress, appraisal, and coping. 1984, New York: Springer.
Mirsky, I.A., et al., Etiology of duodenal ulcer. I. Relation of specific psychological characteristics to rate of gastric secretion (serum pepsinogen). Psychosom Med, 1957. 19(1): p. 1–10.
Engel, G.L., Studies of ulcerative colitis I. Clinical data bearing on the nature of the somatic process. Psychosom Med, 1954. 16(6): p. 496–501.
Whitehead, W.E., et al., Learned illness behavior in patients with irritable bowel syndrome and peptic ulcer. Dig Dis Sci, 1982. 27(3): p. 202–8.
Tache, Y., et al., Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract. Curr Mol Pharmacol, 2018. 11(1): p. 51–71.
Kozakai, Y., et al., The role of peripheral corticotropin-releasing factor signaling in a rat model of stress-induced gastric hyperalgesia. Biochem Biophys Res Commun, 2019. 519(4): p. 797–802.
Nozu, T. and T. Okumura, Corticotropin-releasing factor receptor type 1 and type 2 interaction in irritable bowel syndrome. J Gastroenterol, 2015. 50(8): p. 819–30.
Almy, T.P., F. Kern, Jr., and F.K. Abbot, Constipation and diarrhea, as reactions to life stress. Res Publ Assoc Res Nerv Ment Dis, 1949. 29: p. 724–31.
Almy, T.P., F. Kern, Jr., and M. Tulin, Alterations in colonic function in man under stress; experimental production of sigmoid spasm in healthy persons. Gastroenterology, 1949. 12(3): p. 425–36.
Steadman, C.J., et al., Control of muscle tone in the human colon. Gut, 1992. 33(4): p. 541–6.
Gorard, D.A., et al., Intestinal transit in anxiety and depression. Gut, 1996. 39(4): p. 551–5.
Cao, S.G., et al., Effects of psychological stress on small intestinal motility and expression of cholecystokinin and vasoactive intestinal polypeptide in plasma and small intestine in mice. World J Gastroenterol, 2005. 11(5): p. 737–40.
Welgan, P., H. Meshkinpour, and M. Beeler, Effect of anger on colon motor and myoelectric activity in irritable bowel syndrome. Gastroenterology, 1988. 94(5 Pt 1): p. 1150–6.
Welgan, P., H. Meshkinpour, and L. Ma, Role of anger in antral motor activity in irritable bowel syndrome. Dig Dis Sci, 2000. 45(2): p. 248–51.
Rao, S.S., et al., Psychological and physical stress induce differential effects on human colonic motility. Am J Gastroenterol, 1998. 93(6): p. 985–90.
Tache, Y. and M. Million, Role of corticotropin-releasing factor signaling in stress-related alterations of colonic motility and hyperalgesia. J Neurogastroenterol Motil, 2015. 21(1): p. 8–24.
Tache, Y., Corticotrophin-releasing factor 1 activation in the central amygdale and visceral hyperalgesia. Neurogastroenterol Motil, 2015. 27(1): p. 1–6.
Trzeciak, P. and M. Herbet, Role of the Intestinal Microbiome, Intestinal Barrier and Psychobiotics in Depression. Nutrients, 2021. 13(3).
Koren, O., et al., A guide to enterotypes across the human body: meta-analysis of microbial community structures in human microbiome datasets. PLoS Comput Biol, 2013. 9(1): p. e1002863.
Dusko Ehrlich, S. and MetaH.I.T.consortium. Metagenomics of the intestinal microbiota: potential applications. Gastroenterol Clin Biol, 2010. 34 Suppl 1: p. S23–8.
Sudo, N., et al., Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol, 2004. 558(Pt 1): p. 263–75.
Bailey, M.T., et al., Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behav Immun, 2011. 25(3): p. 397–407.
Greenwood-Van Meerveld, B., A.C. Johnson, and D. Grundy, Gastrointestinal Physiology and Function. Handb Exp Pharmacol, 2017. 239: p. 1–16.
Tache, Y. and M.H. Perdue, Role of peripheral CRF signalling pathways in stress-related alterations of gut motility and mucosal function. Neurogastroenterol Motil, 2004. 16 Suppl 1: p. 137–42.
Pavlov, V.A., S.S. Chavan, and K.J. Tracey, Molecular and Functional Neuroscience in Immunity. Annu Rev Immunol, 2018. 36: p. 783–812.
Overman, E.L., J.E. Rivier, and A.J. Moeser, CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-alpha. PLoS One, 2012. 7(6): p. e39935.
Yuan, P.Q., et al., Urocortins and CRF receptor type 2 variants in the male rat colon: gene expression and regulation by endotoxin and anti-inflammatory effect. Am J Physiol Gastrointest Liver Physiol, 2016. 310(6): p. G387–98.
Tetel, M.J., et al., Steroids, stress and the gut microbiome-brain axis. J Neuroendocrinol, 2018. 30(2).
Kao, A.C., S. Harty, and P.W. Burnet, The Influence of Prebiotics on Neurobiology and Behavior. Int Rev Neurobiol, 2016. 131: p. 21–48.
Barbosa, R.S.D. and M.A. Vieira-Coelho, Probiotics and prebiotics: focus on psychiatric disorders – a systematic review. Nutr Rev, 2020. 78(6): p. 437–450.
Ligezka, A.N., et al., A systematic review of microbiome changes and impact of probiotic supplementation in children and adolescents with neuropsychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry, 2021. 108: p. 110187.
Rincel, M. and M. Darnaudery, Maternal separation in rodents: a journey from gut to brain and nutritional perspectives. Proc Nutr Soc, 2020. 79(1): p. 113–132.
Liu, R.T., R.F.L. Walsh, and A.E. Sheehan, Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials. Neurosci Biobehav Rev, 2019. 102: p. 13–23.
Ansari, F., et al., The Effects of Probiotics and Prebiotics on Mental Disorders: A Review on Depression, Anxiety, Alzheimer, and Autism Spectrum Disorders. Curr Pharm Biotechnol, 2020. 21(7): p. 555–565.
Ritchie, J., Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut, 1973. 14(2): p. 125–32.
Elsenbruch, S. & Labrenz, F. Nocebo effects and experimental models in visceral pain. International Review of Neurobiology, 2018. 138, 285–306.
Ford AC, Sperber AD, Corsetti M, Camilleri M. Irritable bowel syndrome. Lancet. 2020. 21;396(10263):1675–1688. https://doi.org/10.1016/S0140-6736(20)31548-8. Epub 2020 Oct 10. PMID: 33049223.
Schmulson MJ. Brain-gut interaction in irritable bowel syndrome: new findings of a multicomponent disease model. Isr Med Assoc J. 2001. 3(2):104–10. PMID: 11347592.
Zar S, Benson MJ, Kumar D. Rectal afferent hypersensitivity and compliance in irritable bowel syndrome: differences between diarrhoea-predominant and constipation-predominant subgroups. Eur J Gastroenterol Hepatol. 2006. 18(2):151–8. https://doi.org/10.1097/00042737-200602000-00007. PMID: 16394796.
Larauche M, Mulak A, Taché Y. Stress and visceral pain: from animal models to clinical therapies. Exp Neurol. 2012. 233(1):49–67. https://doi.org/10.1016/j.expneurol.2011.04.020. Epub 2011 May 6. PMID: 21575632; PMCID: PMC3224675.
W., J.n. and H.b. H.-J., Physiologie und Pathophysiologie viszeraler Schmerzen. Schmerz, 2002. 16: p. 429–445.
Johnson AC, Tran L, Schulkin J, Greenwood-Van Meerveld B. Importance of stress receptor-mediated mechanisms in the amygdala on visceral pain perception in an intrinsically anxious rat. Neurogastroenterol Motil. 2012. 24(5):479–86, e219. https://doi.org/10.1111/j.1365-2982.2012.01899.x. Epub 2012 Feb 26. PMID: 22364507; PMCID: PMC3461498.
Dolan, R.J., Emotion, cognition, and behavior. Science, 2002. 298(5596): p. 1191–4.
Tillisch K, Mayer EA, Labus JS. Quantitative meta-analysis identifies brain regions activated during rectal distension in irritable bowel syndrome. Gastroenterology. 2011. 140(1):91–100. https://doi.org/10.1053/j.gastro.2010.07.053. Epub 2010 Aug 7. PMID: 20696168; PMCID: PMC3253553.
Elsenbruch S, Rosenberger C, Bingel U, Forsting M, Schedlowski M, Gizewski ER. Patients with irritable bowel syndrome have altered emotional modulation of neural responses to visceral stimuli. Gastroenterology. 2010. 139(4):1310–9. https://doi.org/10.1053/j.gastro.2010.06.054. Epub 2010 Jun 22. PMID: 20600024.
Harlow, H.F., The nature of love. American Psychologist, 1958. 13(12): p. 673–685.
Lopes, L.V., et al., Maternal deprivation affects the neuromuscular protein profile of the rat colon in response to an acute stressor later in life. J Proteomics, 2008. 71(1): p. 80–8.
Medland, J.E., et al., Early life adversity in piglets induces long-term upregulation of the enteric cholinergic nervous system and heightened, sex-specific secretomotor neuron responses. Neurogastroenterol Motil, 2016. 28(9): p. 1317–29.
Thapar (2020) Paediatric functional abdominal pain disorders, Nature Reviews 6: 89
Bolten M. (2019) Klinische Bindungsforschung. In: Schneider S., Margraf J. (eds) Lehrbuch der Verhaltenstherapie, Band 3. Abb. 4.1 /ISBN 978-3-662-57369-3. Berlin, Heidelberg: Springer
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Bolten, M. (2022). Psychosoziale Aspekte der Nahrungsaufnahme, Verdauung und Ausscheidung. In: Funktionelle Magen-Darm-Störungen im Kindes- und Jugendalter. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-64253-5_2
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