Zusammenfassung
Die Leber gilt als das zentrale Stoffwechselorgan des menschlichen Körpers. Neben Proteinbiosynthese, Wärmeregulierung, Glukoseverwertung und Biotransformation sind die Hepatozyten vor allem der Hauptumschlagplatz des Lipidstoffwechsels. Die Leber spielt somit eine entscheidende Rolle in der Fettaufnahme- und Oxidierung, der Fettspeicherung, der Cholesterinsynthese und der Lipogenese. In diesem Kapitel soll auf die Physiologie der hepatischen Fettverdauung und die lipidassoziierte Pathophysiologie der Steatohepatitis eingegangen werden. Dies beinhaltet die Regulation zentraler Stoffwechselprozesse durch nukleäre Rezeptoren, die zentrale Rolle der Insulinresistenz, die Lipotoxizität sowie neue mechanistische Aspekte (z. B. Autophagie).
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Bechmann, L.P., Geier, A., Canbay, A. (2022). Pathophysiologie: Lipidstoffwechsel. In: Geier, A., Canbay, A., Lammert, F. (eds) Nicht-alkoholische Fettlebererkrankung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-62484-5_5
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