Skip to main content
SpringerLink
Log in

In-vitro-Maturation (IVM)

  • Chapter
  • First Online:
Reproduktionsmedizin

Part of the book series: Springer Reference Medizin ((SRM))

  • 4650 Accesses

Zusammenfassung

Die In-vitro-Maturation (IVM) ist eine Technik der extracorporalen Befruchtung, bei der ohne oder nur mit kurzer niedrig dosierter kontrollierter ovarieller Überstimulation Eizellen gewonnen, in vitro nachgereift und anschließend fertilisiert werden. Hauptindikation besteht bei Frauen mit einem PCO-Syndrom zur Vermeidung eines ovariellen Überstimulationssyndroms. Die Schwangerschaftsraten erreichen die Erfolge der konventionellen In-vitro-Fertilisation. Obwohl theoretisch die beschleunigte In-vitro-Maturation sich negativ auswirken könnte, werden bislang keine erhöhten Fehlbildungsraten berichtet. Die erste Zweijahresnachbeobachtung zur mentalen Entwicklung von Kindern nach IVM hat im Vergleich zur In-vitro-Fertilisation (IVF) bzw. intrazytoplasmatischen Spermieninjektion (ICSI) keine Unterschiede ergeben. Zusammenfassend hat sich die IVM als Behandlungsmethode bei speziellen Risikokonstellationen bewährt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 289.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Barnes FL, Kausche A, Tiglias J, Wood C, Wilton L, Trounson A (1996) Production of embryos from in vitro-matured primary human oocytes. Fertil Steril 65:1151–1156

    Article  CAS  PubMed  Google Scholar 

  • Benkhalifa M, Demirol A, Ménézo Y, Balashova E, Abduljalil AK, Abbas S, Giakoumakis I, Gurgan T (2009) Natural cycle IVF and oocyte in-vitro maturation in polycystic ovary syndrome: a collaborative prospective study. Reprod Biomed Online 18:29–36

    Article  CAS  PubMed  Google Scholar 

  • Buckett WM, Chian RC, Holzer H, Dean N, Usher R, Tan SL (2007) Obstetric outcomes and congenital abnormalities after in vitro maturation, in vitro fertilization, and intracytoplasmic sperm injection. Obstet Gynecol 110:885–891

    Article  PubMed  Google Scholar 

  • Cha KY, Koo JJ, Ko JJ, Choi DH, Han SY, Yoon TK (1991) Pregnancy after in vitro fertilization of human follicular oocytes collected from nonstimulated cycles, their culture in vitro and their transfer in a donor oocyte program. Fertil Steril 55:109–113

    Article  CAS  PubMed  Google Scholar 

  • Cha KY, Han SY, Chung HM, Choi DH, Lim JM, Lee WS, Ko JJ, Yoon TK (2000) Pregnancies and deliveries after in vitro maturation culture followed by in vitro fertilization and embryo transfer without stimulation in women with polycystic ovary syndrome. Fertil Steril 73:978–983

    Article  CAS  PubMed  Google Scholar 

  • Cha KY, Chung HM, Lee DR, Kwon H, Chung MK, Park LS, Choi DH, Yoon TK (2005) Obstetric outcome of patients with polycystic ovary syndrome treated by in vitro maturation and in vitro fertilization-embryo transfer. Fertil Steril 83:1461–1465

    Article  PubMed  Google Scholar 

  • Chian RC, Park SE, Park EH (1997) Molecular and structural characteristics between immature human oocytes retreived from stimulated and unstimulated ovaries. In: Gromel V, PCK L (Hrsg) vitro fertilization and assisted reproduction. Monduzzi Editiore, Bologna, S 315–319

    Google Scholar 

  • Chian RC, Buckett WM, Tulandi T, Tan SL (2000) Prospective randomized study of human chorionic gonadotrophin priming before immature oocyte retrieval from unstimulated women with polycystic ovarian syndrome. Hum Reprod 15:165–170

    Article  CAS  PubMed  Google Scholar 

  • Chian RC, Buckett WM, Tan SL (2003) In-vitro maturation of human oocytes. Reprod Biomed Online 8:148–166

    Article  Google Scholar 

  • Child TJ, Phillips SJ, Abdul-Jalil AK, Gulekli B, Tan SL (2002) A comparison of in vitro maturation and in vitro fertilization for women with polycystic ovaries. Obstet Gynecol 100:665–670

    PubMed  Google Scholar 

  • Creux H, Monnier P, Son WY, Tulandi T, Buckett W (2017) Immature oocyte retrieval and in vitro oocyte maturation at different phases of the menstrual cycle in women with cancer who require urgent gonadotoxic treatment. Fertil Steril 107:198–204

    Article  PubMed  Google Scholar 

  • Dal Canto MC, Novara PV, Coticchio G, Mignini Renzini M, Brambillasca F, Brigante C, De Ponti E, Fadini R (2016) Morphokinetics of embryos developed from oocytes matured in vitro. J Assist Reprod Genet 33:247–253. https://doi.org/10.1007/s10815-015-0625-9. Epub 4 Dec 2015

    Article  PubMed  Google Scholar 

  • Das M, Son WY, Buckett W, Tulandi T, Holzer H (2014) In-vitro maturation versus IVF with GnRH antagonist for women with polycystic ovary syndrome: treatment outcome and rates of ovarian hyperstimulation syndrome. Reprod Biomed Online 29:545–551

    Article  CAS  PubMed  Google Scholar 

  • Demirtas E, Elizur SE, Holzer H, Gidoni Y, Son WY, Chian RC, Tan SL (2008) Immature oocyte retrieval in the luteal phase to preserve fertility in cancer patients. Reprod Biomed Online 17:520–523

    Article  PubMed  Google Scholar 

  • Edwards RG, Bavister BD, Steptoe PC (1969) Early stages of fertilization in vitro of human oocytes matured in vitro. Nature 221:632–635

    Article  CAS  PubMed  Google Scholar 

  • Ellenbogen A, Atamny R, Fainaru O, Meidan E, Rotfarb N, Michaeli M (2011) In vitro maturation of oocytes: a novel method of treatment of patients with polycystic ovarian syndrome undergoing in vitro fertilization. Harefuah 150:833–836

    PubMed  Google Scholar 

  • Fadini R, Mignini Renzini M, Guarnieri T, Dal Canto M, De Ponti E, Sutcliffe A, Shevlin M, Comi R, Coticchio G (2012) Comparison of the obstetric and perinatal outcomes of children conceived from in vitro or in vivo matured oocytes in in vitro maturation treatments with births form conventional ICSI cycles. Hum Reprod 27:3601–3608

    Article  CAS  PubMed  Google Scholar 

  • Foix-L’Hélias L, Grynberg M, Ducot B, Frydman N, Kerbrat V, Bouyer J, Labrune P (2014) Growth development of french children born after in vitro maturation. PLoS One 9:e89713

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ganor-Paz Y, Friedler-Mashiach Y, Ghetler Y, Hershko-Klement A, Berkovitz A, Gonen O, Shulman A, Wiser A (2016) What is the best treatment for women with polycystic ovarian syndrome and high LH/FSH ratio? A comparison among in vitro fertilization with GnRH agonist, GnRH antagonist and in vitro maturation. J Endocrinol Investig 39:799–803

    Article  CAS  Google Scholar 

  • Gicquel C, Gaston V, Mandelbaum J, Siffroi JP, Flahault A, Le Bouc Y (2003) In vitro fertilization may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCN1OT gene. Am J Hum Genet 72:1338–1341

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gougeon A (1996) Regulation of ovarian follicular development in primates: facts and hypotheses. Endocr Rev 17:121–155

    Article  CAS  PubMed  Google Scholar 

  • Grynberg M, Poulain M, le Parco S, Sifer C, Fanchin R, Frydman N (2016) Similar in vitro maturation rates of oocytes retrieved during the follicular or luteal phase offer flexible options for urgent fertility preservation in breast cancer patients. Hum Reprod 31:623–629

    Article  CAS  PubMed  Google Scholar 

  • Heijnen EM, Eijkemans MJ, Hughes EG, Laven JS, Macklon NS, Fauser BC (2006) A meta-analysis of outcomes of conventional IVF in women with polycystic ovary syndrome. Hum Reprod Update 12:13–21

    Article  CAS  PubMed  Google Scholar 

  • Horsthemke B, Ludwig M (2005) Assisted reproduction: the epigenetic perspective. Hum Reprod Update 11(5):473–482

    Article  PubMed  Google Scholar 

  • Huang JY, Chian RC, Gilbert L, Fleiszer D, Holzer H, Dermitas E, Elizur SE, Gidoni Y, Levin D, Son WY, Tan SL (2010) Retrieval of immature oocytes from unstimulated ovaries followed by in vitro maturation and vitrification: a novel strategy of fertility preservation for breast cancer patients. Am J Surg 200:177–183

    Article  PubMed  Google Scholar 

  • Hwang JL, Lin YH, Tsai YL (2000) In vitro maturation and fertilization of immature oocytes: a comparative study of fertilization techniques. J Assist Reprod Genet 17:39–43

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Le Du A, Kadoch IJ, Bourcigaux N, Doumerc S, Bourrier MC, Chevalier N, Fanchin R, Chian RC, Tachdjian G, Frydman R, Frydman N (2005) In vitro oocyte maturation for the treatment of infertility associated with polycystic ovarian syndrome: the French experience. Hum Reprod 20:420–424

    Article  PubMed  Google Scholar 

  • Lin YH, Hwang JL, Huang LW, Mu SC, Seow KM, Chung J, Hsieh BC, Huang SC, Chen CY, Chen PH (2003) Combination of FSH priming and hCG priming for in-vitro maturation of human oocytes. Hum Reprod 18:1632–1636

    Article  CAS  PubMed  Google Scholar 

  • Maher ER, Brueton LA, Bowdin SC, Luharia A, Cooper W, Cole TR, Macdonald F, Sampson JR, Barratt CL, Reik W, Hawkins MM (2003) Beckwith-Wiedemann syndrome and assisted reproduction technology (ART). J Med Genet 40:62–64

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Maman E, Meirow D, Brengauz M, Raanani H, Dor J, Hourvitz A (2011) Luteal phase oocyte retrieval and in vitro maturation is an optional procedure for urgent fertility preservation. Fertil Steril 95:64–67. https://doi.org/10.1016/j.fertnstert.2010.06.064. Epub 5 Aug 2010

    Article  PubMed  Google Scholar 

  • Mikkelsen AL (2005) Strategies in human in-vitro maturation and their clinical outcome. Reprod Biomed Online 10:593–599

    Article  PubMed  Google Scholar 

  • Montag M, Isachenko V, Isachenko E et al (2006) Generierung und Konservierung von Keimzellen. Gynäkol Endokrinol 4:205–210

    Article  Google Scholar 

  • Pliushch G, Schneider E, Schneider T, El Hajj N, Rösner S, Strowitzki T, Haaf T (2015) In vitro maturation of oocytes is not associated with altered deoxyribonucleic acid methylation patterns in children from in vitro fertilization or intracytoplasmic sperm injection. Fertil Steril 103:720–727

    Article  PubMed  Google Scholar 

  • Reik W, Maher ER (1997) Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome. Trends Genet 13:330–334

    Article  CAS  PubMed  Google Scholar 

  • Reik W, Walter J (2001) Genomic imprinting: parental influence on the genome. Nat Rev Genet 2:21–32

    Article  CAS  PubMed  Google Scholar 

  • Roesner S, Von Wolff M, Eberhardt I, Beuter-Winkler P, Toth B, Strowitzki T (2012) In vitro maturation: a five-year experience. Acta Obstet Gynecol Scand 91:22–27

    Article  PubMed  Google Scholar 

  • Roesner S, Dietrich JE, Weigert J, Montag M, Toth B, Strowitzki T (2017a) Time-lapse imaging reveals differences in growth dynamics of embryos after in vitro maturation compared with conventional stimulation. Fertil Steril 107:606–612.e3

    Article  PubMed  Google Scholar 

  • Roesner S, von Wolff M, Elsaesser M, Roesner K, Reuner G, Pietz J, Bruckner T, Strowitzki T (2017b) Two-year development of children conceived by IVM: a prospective controlled single-blinded study. Hum Reprod 1(32):1341–1350

    Article  Google Scholar 

  • Russell JB, Knezevich KM, Fabian KF, Dickson JA (1997) Unstimulated immature oocyte retrieval: early versus midfollicular endometrial priming. Fertil Steril 67:616–620

    Article  CAS  PubMed  Google Scholar 

  • Shalom-Paz E, Holzer H, Young Son W, Levin I, Tan SL, Almog B (2012) PCOS patients can benefit from in vitro maturation (IVM) of oocytes. Eur J Obstet Gynecol Reprod Biol 165:53–56

    Article  PubMed  Google Scholar 

  • Shavit T, Ellenbogen A, Michaeli M, Kartchovsky E, Ruzov O, Shalom-Paz E (2014) In-vitro maturation of oocytes vs in-vitro fertilization with a gonadotropin-releasing hormone antagonist for women with polycystic ovarian syndrome: can superiority be defined? Eur J Obstet Gynecol Reprod Biol 179:46–50

    Article  CAS  PubMed  Google Scholar 

  • Shu-Chi M, Jiann-Loung H, Yu-Hung L, Tseng-Chen S, Ming-I L, Tsu-Fuh Y (2006) Growth and development of children conceived by in-vitro maturation of human oocytes. Early Hum Dev 82:677–682

    Article  PubMed  Google Scholar 

  • Söderström-Anttila V, Salokorpi T, Pihlaja M, Serenius-Sirve S, Suikkari AM (2006) Obstetric and perinatal outcome and preliminary results of development of children born after in vitro maturation of oocytes. Hum Reprod 24:1508–1513

    Article  Google Scholar 

  • Son WY, Chung JT, Herrero B, Dean N, Demirtas E, Holzer H, Elizur S, Chian RC, Tan SL (2008a) Selection of the optimal day for oocyte retrieval based on the diameter of the dominant follicle in hCG-primed in vitro maturation cycles. Hum Reprod 23:2680–2685

    Article  CAS  PubMed  Google Scholar 

  • Son WY, Chung JT, Demirtas E, Holzer H, Sylvestre C, Buckett W, Chian RC, Tan SL (2008b) Comparison of in-vitro maturation cycles with and without in-vivo matured oocytes retrieved. Reprod Biomed Online 17:59–67

    Article  PubMed  Google Scholar 

  • Sonigo C, Simon C, Boubaya M, Benoit A, Sifer C, Sermondade N, Grynberg M (2016) What threshold values of antral follicle count and serum AMH levels should be considered for oocyte cryopreservation after in vitro maturation. Hum Reprod 31:1493–1500

    Article  CAS  PubMed  Google Scholar 

  • Thibault C, Gerard M, Menezo Y (1975) Preovulatory and ovulatory mechanisms in oocyte maturation. J Reprod Fertil 45:605–610

    Article  CAS  PubMed  Google Scholar 

  • Trounson A, Wood C, Kausche A (1994) In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients. Fertil Steril 62:353–362

    Article  CAS  PubMed  Google Scholar 

  • Tummon I, Gavrilova-Jordan L, Allemand MC, Session D (2005) Polycystic ovaries and ovarian hyperstimulation syndrome: a systematic review. Acta Obstet Gynecol Scand 84:611–616

    PubMed  Google Scholar 

  • Vitek WS, Witmyer J, Carson SA, Robins JC (2013) Estrogen-suppressed in vitro maturation: a novel approach to in vitro maturation. Fertil Steril 99:1886–1890

    Article  CAS  PubMed  Google Scholar 

  • Zhang XY, Ata B, Son WY, Buckett WM, Tan SL, Ao A (2010) Chromosome abnormality rates in human embryos obtained from in-vitro maturation and IVF treatment cycles. Reprod Biomed Online 21:552–559

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung für Gynäkologische Endokrinologie und Fertilitätsstörungen, Universitätsklinikum Heidelberg Frauenklinik, Heidelberg, Deutschland

    Thomas Strowitzki & Sabine Rösner

  2. Facharzt-Zentrum für Kinderwunsch, Pränatale Medizin, Endokrinologie und Osteologie Hamburg GmbH, amedes experts, Hamburg, Deutschland

    Klaus Diedrich

  3. Universitäts-Frauenklinik Lübeck, Lübeck, Deutschland

    Klaus Diedrich

Authors
  1. Thomas Strowitzki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Klaus Diedrich
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sabine Rösner
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Thomas Strowitzki .

Editor information

Editors and Affiliations

  1. Facharzt-Zentrum für Kinderwunsch Pränatale Medizin, Endokrinologie und Osteologie Hamburg GmbH, amedes experts, Hamburg, Germany

    Klaus Diedrich

  2. SYNLAB Holding Deutschland GmbH, Augsburg, Germany

    Michael Ludwig

  3. Sektion für gynäkologische Endokrinologie und Reproduktionsmedizin, Universitätsklinikum Schleswig-Holstein – Campus Lübeck, Lübeck, Germany

    Georg Griesinger

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Strowitzki, T., Diedrich, K., Rösner, S. (2020). In-vitro-Maturation (IVM). In: Diedrich, K., Ludwig, M., Griesinger, G. (eds) Reproduktionsmedizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-57636-6_25

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-57636-6_25

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-57635-9

  • Online ISBN: 978-3-662-57636-6

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation