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Physiologie der Spermienreifung und Fertilisierung

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Andrologie

Part of the book series: Springer Reference Medizin ((SRM))

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Zusammenfassung

Die erfolgreiche Befruchtung einer Eizelle ist das ultimative Ziel für ein reifes Spermium. Damit dieser Vorgang in vivo korrekt abläuft, folgt der natürliche Befruchtungsprozess einer zeit- und lokalisationsabhängigen Sequenz komplexer Schritte, beginnend bei der Produktion im Hoden, über die Reifung im Nebenhoden und letztendlich bei der Befruchtung der Eizelle. Spezifische Proteine und Oberflächenkomponenten in und an den Spermatozoen spielen dabei eine wichtige Rolle. Bei fertilen Männern erfolgt die natürliche Befruchtung der logisch bestimmten Reihenfolge der Ereignisse, bei infertilen Männern jedoch können diese Wege teilweise therapeutisch abgekürzt werden, um so letzendlich auch eine Vaterschaft herbeizuführen. So können nicht nur ejakulierte Spermatozoen, z. B. in vivo nach Insemination in den weiblichen Genitaltrakt, sondern auch Spermatozoen aus dem Hoden und dem Nebenhoden nach Injektion in die Eizelle in vitro vorherbestimmte Befruchtungsschritte ausführen und so zu einer intakten Schwangerschaft führen. Dieses Buchkapitel folgt dem Weg der Spermien vom Ort der Produktion bis zur befruchtungsfähigen Eizelle und beschreibt wichtige Prozesse, die Spermatozoen durchlaufen, um letztendlich ihr Ziel zu erreichen.

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  1. Centrum für Reproduktionsmedizin und Andrologie, Universitätsklinikum Münster, Münster, Deutschland

    Verena Nordhoff & Joachim Wistuba

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Correspondence to Verena Nordhoff .

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Editors and Affiliations

  1. Centrum für Reproduktionsmedizin und And, Universität Münster, Münster, Deutschland

    Eberhard Nieschlag

  2. Zentrum für Reproduktionsmedizin und And, Universität Halle-Wittenberg Universitätsklinikum Halle (Saale), Halle, Sachsen-Anhalt, Deutschland

    Hermann M. Behre

  3. Abt. Klinische/Operative Andrologie, Universitätsklinikum Münster, Münster, Nordrhein-Westfalen, Deutschland

    Sabine Kliesch

  4. Zentrum für Reproduktionsmedizin und And, Universitätsklinikum Münster, Münster, Deutschland

    Susan Nieschlag

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Nordhoff, V., Wistuba, J. (2021). Physiologie der Spermienreifung und Fertilisierung. In: Nieschlag, E., Behre, H.M., Kliesch, S., Nieschlag, S. (eds) Andrologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-61904-9_3-1

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  • DOI: https://doi.org/10.1007/978-3-662-61904-9_3-1

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  • Print ISBN: 978-3-662-61904-9

  • Online ISBN: 978-3-662-61904-9

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