Zusammenfassung
Es werden die unterschiedlichen Pathomechanismen ausgewählter peripherer Nervenerkrankungen diskutiert und die vielfältigen Ursachen dargestellt. Neben der häufig auftretenden, diabetischen Polyneuropathie werden die akut und chronisch inflammatorischen Neuropathien besprochen. Es werden die verschiedenen Schädigungsmuster auf makroskopischer als auch histologischer Ebene dargestellt und beteiligte Stoffwechselwege, zelluläre Schädigungsmechanismen und immunologische Hintergründe beleuchtet. Insbesondere die ursächlichen Auslöser sowie die Autoimmunmechanismen des Guillain-Barré-Syndroms (GBS) als auch der chronischen inflammatorisch-demyelinisierenden Polyneuropathie werden betrachtet und Therapiemöglichkeiten kritisch diskutiert. Das Prinzip des molekularen Mimikry wird vermittelt.
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Sturm, D., Pitarokoili, K. (2019). Erkrankungen peripherer Nerven. In: Sturm, D., Biesalski, AS., Höffken, O. (eds) Neurologische Pathophysiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-56784-5_6
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