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Intraperitoneale intraoperative Chemotherapie (HIPEC/PIPAC)

Kompendium Internistische Onkologie

Part of the book series: Springer Reference Medizin ((SRM))

  • 32 Accesses

Zusammenfassung

Die intraperitoneale intraoperative Chemotherapie ist eine Verabreichungsform der Chemotherapie, die im Rahmen einer offenen Operation erfolgt, entweder additiv nach einer Resektion (für die hypertherme intraperitoneale Chemotherapie, HIPEC) mit einem kurativen Ansatz oder aber laparoskopisch (intraperitoneale Druck-Aerosolchemotherapie, PIPAC) in palliativer Intention und ohne Durchführung einer Resektion. Die Voraussetzung für die HIPEC ist die makroskopisch komplette Tumorresektion. Die PIPAC dient zur Behandlung typischer Komplikationen der Peritonealkarzinose, insbesondere des therapierefraktären Aszites. Wie für viele lokoregionale Verfahren liegen auch für die HIPEC und die PIPAC kaum oder nur wenige Daten aus Phase-III-Studien vor. Deswegen soll die Indikationsstellung interdisziplinär erfolgen und mit dem Patienten im Sinne einer partizipativen Entscheidung besprochen werden. Sinnvoll ist, die Behandlung in erfahrenen „High-volume“-Zentren durchzuführen, auch um die Komplikationsrate niedrig zu halten.

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Notes

  1. 1.

    PubMed Recherche am 27.01.2021 mit dem Schlüsselwort „PIPAC“.

  2. 2.

    Recherche auf clinialtrials.gov am 27.01.2021 mit den Schlüsselwörtern „PIPAC“ und „recruiting“.

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Authors and Affiliations

  1. Klinik für Allgemein- und Viszeralchirurgie, Krankenhaus Barmherzige Brüder Regensburg, Regensburg, Deutschland

    Pompiliu Piso

  2. Universitätsklinikum Halle (Saale)/Martin-Luther-University Halle-Wittenberg, Halle, Deutschland

    Christoph Raspé

  3. Department of Visceral, Vascular and Endocrine Surgery, Universitätsklinikum Halle (Saale)/Martin-Luther-University Halle-Wittenberg, Halle, Deutschland

    Jörg Kleef

  4. Medizinische Klinik III (Hämatologie-Internistische Onkologie), Marien Hospital Herne, Ruhr-Universität Bochum, Herne, Deutschland

    Dirk Strumberg

  5. Nationales Zentrum für Pleura und Peritoneum, Karls-Eberhard Universität Tübingen, Tübingen, Deutschland

    Marc A. Reymond

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Piso, P., Raspé, C., Kleef, J., Strumberg, D., Reymond, M.A. (2021). Intraperitoneale intraoperative Chemotherapie (HIPEC/PIPAC). In: Schmoll, HJ. (eds) Kompendium Internistische Onkologie . Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46764-0_201-1

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    Intraperitoneale intraoperative Chemotherapie (HIPEC/PIPAC)
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    16 June 2021

    DOI: https://doi.org/10.1007/978-3-662-46764-0_201-2

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    Intraperitoneale intraoperative Chemotherapie (HIPEC/PIPAC)
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    DOI: https://doi.org/10.1007/978-3-662-46764-0_201-1

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