Skip to main content

Maschinelle Beatmung und Entwöhnung von der Beatmung

  • Chapter
  • First Online:
Die Intensivmedizin

Zusammenfassung

Die maschinelle Beatmung mit positivem Atemwegsdruck dient der Übernahme oder Unterstützung der Ventilation und der Aufrechterhaltung eines ausreichenden pulmonalen Gasaustauschs bei der akuten respiratorischen Insuffizienz. Bei physiologischer Atmung wird von der Atemmuskulatur ein negativer Druckgradient aufgebaut, dem entlang inspiratorisch Gas in die Lungen fließt. Bei der Beatmung resultiert demgegenüber der inspiratorische Druckgradient aus einem positiven Atemwegsdruck. Die Umkehrung der intrathorakalen Druckverhältnisse hat zahlreiche pathophysiologische Konsequenzen. Dementsprechend ist mit der maschinellen Beatmung ein Überwachungsaufwand verbunden, der lediglich auf einer Intensivstation gewährleistet werden kann.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 389.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Aubier M (1989) Respiratory muscle fatigue. Intens Care Med 15 Suppl 1:17–S20

    Google Scholar 

  • Baum M, Benzer H, Putensen C, Koller W, Putz G (1989) Biphasic positive airway pressure (BIPAP)--a new form of augmented ventilation. Anaesthesist 38:452–458

    CAS  PubMed  Google Scholar 

  • Bein T, Weber-Carstens S, Goldmann A, Müller T, Staudinger T, Brederlau J, Muellenbach R, Dembinski R, Graf BM, Wewalka M, Philipp A, Wernecke KD, Lubnow M, Slutsky AS (2013) Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus ’conventional’ protective ventilation (6 ml/kg) in severe ARDS: the prospective randomized Xtravent-study. Intensive Care Med 39:847–56

    PubMed Central  PubMed  Google Scholar 

  • Bickenbach J, Dembinski R, Czaplik M, Meissner S, Tabuchi A, Mertens M, Knels L, Schroeder W, Pelosi P, Koch E, Kuebler WM, Rossaint R, Kuhlen R (2009) Comparison of two in vivo microscopy techniques to visualize alveolar mechanics. J Clin Monit Comput 23:323–332

    PubMed  Google Scholar 

  • Bickenbach J, Czaplik M, Dembinski R, Pelosi P, Schroeder W, Marx G, Rossaint R (2010) In vivo microscopy in a porcine model of acute lung injury. Respir Physiol Neurobiol 172:192–200

    PubMed  Google Scholar 

  • Boles JM, Bion J, Connors A, Herridge M, Marsh B, Melot C, Pearl R, Silverman H, Stanchina M, Vieillard-Baron A, Welte T (2007) Weaning from mechanical ventilation. Eur Respir J 29:1033–1056

    PubMed  Google Scholar 

  • Boulain T (1998) Unplanned extubations in the adult intensive care unit: a prospective multicenter study. Association des Reanimateurs du Centre-Ouest. Am J Respir Crit Care Med 157:1131–1137

    CAS  PubMed  Google Scholar 

  • Brochard L, Harf A, Lorino H, Lemaire F (1989) Inspiratory pressure support prevents diaphragmatic fatigue during weaning from mechanical ventilation. Am Rev Respir Disease 139:513–521

    CAS  Google Scholar 

  • Brochard L, Rua F, Lorino H, Lemaire F, Harf A (1991) Inspiratory pressure support compensates for the additional work of breathing caused by the endotracheal tube. Anesthesiology 75:739–745

    CAS  PubMed  Google Scholar 

  • Brochard L, Rauss A, Benito S, Conti G, Mancebo J, Rekik N, Gasparetto A, Lemaire F (1994) Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med 150:896–903

    CAS  PubMed  Google Scholar 

  • Brochard L, Mancebo J, Wysocki M, Lofaso F, Conti G, Rauss A, Simonneau G, Benito S, Gasparetto A, Lemaire F (1995) Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease. N Engl J Med 333:817–822

    CAS  PubMed  Google Scholar 

  • Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT (2004) Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 351:327–336

    PubMed  Google Scholar 

  • Calverley PM, Koulouris NG (2005) Flow limitation and dynamic hyperinflation: key concepts in modern respiratory physiology. Eur Respir J 25:186–199

    CAS  PubMed  Google Scholar 

  • Clec’h C, Alberti C, Vincent F, Garrouste-Org LA, Toledano D, Azoulay E, Adrie C, Jamali S, Zaccaria I, Cohen Y, Timsit JF (2007) Tracheostomy does not improve the outcome of patients requiring prolonged mechanical ventilation: a propensity analysis. Crit Care Med 35:132–138

    PubMed  Google Scholar 

  • Combes A, Luyt CE, Nieszkowska A, Trouillet JL, Gibert C, Chastre J (2007) Is tracheostomy associated with better outcomes for patients requiring long-term mechanical ventilation? Crit Care Med 35:802–807

    PubMed  Google Scholar 

  • Delclaux C, L’Her E, Alberti C, Mancebo J, Abroug F, Conti G, Guerin C, Schortgen F, Lefort Y, Antonelli M, Lepage E, Lemaire F, Brochard L (2000) Treatment of acute hypoxemic nonhypercapnic respiratory insufficiency with continuous positive airway pressure delivered by a face mask: A randomized controlled trial. JAMA 284:2352–2360

    CAS  PubMed  Google Scholar 

  • Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL (2008) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 36:296–327

    PubMed  Google Scholar 

  • Determann RM, Royakkers A, Wolthuis EK, Vlaar AP, Choi G, Paulus F, Hofstra JJ, de Graaff MJ, Korevaar JC, Schultz MJ (2010) Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial. Crit Care 14:R1

    PubMed Central  PubMed  Google Scholar 

  • Downar J, Mehta S (2006) Bench-to-bedside review: high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome. Crit Care 10:240

    PubMed Central  PubMed  Google Scholar 

  • Durbin CG Jr, Perkins MP, Moores LK (2010) Should tracheostomy be performed as early as 72 hours in patients requiring prolonged mechanical ventilation? Respir Care 55:76–87

    PubMed  Google Scholar 

  • Ely EW, Baker AM, Dunagan DP, Burke HL, Smith AC, Kelly PT, Johnson MM, Browder RW, Bowton DL, Haponik EF (1996) Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. NEnglJ Med 335:1864–1869

    CAS  PubMed  Google Scholar 

  • Ely EW, Truman B, Shintani A, Thomason JW, Wheeler AP, Gordon S, Francis J, Speroff T, Gautam S, Margolin R, Sessler CN, Dittus RS, Bernard GR (2003) Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA 289:2983–2991

    PubMed  Google Scholar 

  • Esteban A, Frutos F, Tobin MJ, Alia I, Solsona JF, Valverdu I, Fernandez R, de la Cal MA, Benito S, Tomas R (1995) A comparison of four methods of weaning patients from mechanical ventilation. Spanish Lung Failure Collaborative Group. N Engl J Med 332:345–350

    CAS  PubMed  Google Scholar 

  • Esteban A, Alia I, Gordo F, Fernandez R, Solsona JF, Vallverdu I, Macias S, Allegue JM, Blanco J, Carriedo D, Leon M, de la Cal MA, Taboada F, Gonzalez V, Palazon E, Carrizosa F, Tomas R, Suarez J, Goldwasser RS (1997) Extubation outcome after spontaneous breathing trials with T-tube or pressure support ventilation. The Spanish Lung Failure Collaborative Group. Am J Respir Crit Care Med 156:459–465

    CAS  PubMed  Google Scholar 

  • Esteban A, Alia I, Tobin MJ, Gil A, Gordo F, Vallverdu I, Blanch L, Bonet A, Vazquez A, Torres A, de la Cal MA, Macias S (1999) Effect of spontaneous breathing trial duration on outcome of attempts to discontinue mechanical ventilation. Spanish Lung Failure Collaborative Group. Am J Respir Crit Care Med 159:512–518

    CAS  PubMed  Google Scholar 

  • Esteban A, Anzueto A, Frutos F, Alia I, Brochard L, Stewart TE, Benito S, Epstein SK, Apezteguia C, Nightingale P, Arroliga AC, Tobin MJ (2002) Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 287:345–355

    PubMed  Google Scholar 

  • Esteban A, Frutos-Vivar F, Ferguson ND, Arabi Y, Apezteguia C, Gonzalez M, Epstein SK, Hill NS, Nava S, Soares MA, D’Empaire G, Alia I, Anzueto A (2004) Noninvasive positive-pressure ventilation for respiratory failure after extubation. N Engl J Med 350:2452–2460

    CAS  PubMed  Google Scholar 

  • Esteban A, Ferguson ND, Meade MO, Frutos-Vivar F, Apezteguia C, Brochard L, Raymondos K, Nin N, Hurtado J, Tomicic V, Gonzalez M, Elizalde J, Nightingale P, Abroug F, Pelosi P, Arabi Y, Moreno R, Jibaja M, D’Empaire G, Sandi F, Matamis D, Montanez AM, Anzueto A (2008) Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med 177:170–177

    PubMed  Google Scholar 

  • Ezingeard E, Diconne E, Guyomarc’h S, Venet C, Page D, Gery P, Vermesch R, Bertrand M, Pingat J, Tardy B, Bertrand JC, Zeni F (2006) Weaning from mechanical ventilation with pressure support in patients failing a T-tube trial of spontaneous breathing. Intens Care Med 32:165–169

    Google Scholar 

  • Fabry B, Guttmann J, Eberhard L, Bauer T, Haberthur C, Wolff G (1995) An analysis of desynchronization between the spontaneously breathing patient and ventilator during inspiratory pressure support. Chest 107:1387–1394

    CAS  PubMed  Google Scholar 

  • Fabry B, Haberthur C, Zappe D, Guttmann J, Kuhlen R, Stocker R (1997) Breathing pattern and additional work of breathing in spontaneously breathing patients with different ventilatory demands during inspiratory pressure support and automatic tube compensation. Intens Care Med 23:545–552

    CAS  Google Scholar 

  • Falke KJ, Pontoppidan H, Kumar A, Leith DE, Geffin B, Laver MB (1972) Ventilation with end-expiratory pressure in acute lung disease. J Clin Invest 51:2315–2323

    CAS  PubMed Central  PubMed  Google Scholar 

  • Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P, Zhou Q, Matte A, Walter SD, Lamontagne F, Granton JT, Arabi YM, Arroliga AC, Stewart TE, Slutsky AS, Meade MO, OSCILLATE Trial Investigators, Canadian Critical Trials Group (2013) High frequency oscillation in early acute respiratory distress syndrome. New Engl J Med 368:795–805

    CAS  PubMed  Google Scholar 

  • Ferrer M, Esquinas A, Arancibia F, Bauer TT, Gonzalez G, Carrillo A, Rodriguez-Roisin R, Torres A (2003) Noninvasive ventilation during persistent weaning failure: a randomized controlled trial. AmJ Respir Crit Care Med 168:70–76

    PubMed  Google Scholar 

  • Ferrer M, Valencia M, Nicolas JM, Bernadich O, Badia JR, Torres A (2006) Early noninvasive ventilation averts extubation failure in patients at risk: a randomized trial. Am J Respir Crit Care Med 173:164–170

    PubMed  Google Scholar 

  • Frank JA, Parsons PE, Matthay MA (2006) Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Chest 130:1906–1914

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gattinoni L, Caironi P, Cressoni M, Chiumello D, Ranieri VM, Quintel M, Russo S, Patroniti N, Cornejo R, Bugedo G (2006) Lung recruitment in patients with the acute respiratory distress syndrome. N Engl J Med 354:1775–1786

    CAS  PubMed  Google Scholar 

  • Girard TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD, Pun BT, Taichman DB, Dunn JG, Pohlman AS, Kinniry PA, Jackson JC, Canonico AE, Light RW, Shintani AK, Thompson JL, Gordon SM, Hall JB, Dittus RS, Bernard GR, Ely EW (2008) Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet 371:126–134

    PubMed  Google Scholar 

  • Goldstone J (2002) The pulmonary physician in critical care. 10: difficult weaning. Thorax 57:986–991

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gray A, Goodacre S, Newby DE, Masson M, Sampson F, Nicholl J (2008) Noninvasive ventilation in acute cardiogenic pulmonary edema. N Engl J Med 359:142–151

    CAS  PubMed  Google Scholar 

  • Guerin C, Milic-Emili J, Fournier G (2000) Effect of PEEP on work of breathing in mechanically ventilated COPD patients. Intens Care Med 26:1207–1214

    CAS  Google Scholar 

  • Guttmann J, Eberhard L, Fabry B, Bertschmann W, Wolff G (1993) Continuous calculation of intratracheal pressure in tracheally intubated patients. Anesthesiology 79:503–513

    CAS  PubMed  Google Scholar 

  • Guttmann J, Haberthur C, Mols G, Lichtwarck-Aschoff M (2002) Automatic tube compensation (ATC). Minerva Anestesiol 68:369–377

    CAS  PubMed  Google Scholar 

  • Henzler D, Dembinski R, Bensberg R, Hochhausen N, Rossaint R, Kuhlen R (2004) Ventilation with biphasic positive airway pressure in experimental lung injury. Influence of transpulmonary pressure on gas exchange and haemodynamics. Intens Care Med 30:935–943

    Google Scholar 

  • Henzler D, Pelosi P, Bensberg R, Dembinski R, Quintel M, Pielen V, Rossaint R, Kuhlen R (2006) Effects of partial ventilatory support modalities on respiratory function in severe hypoxemic lung injury. Crit Care Med 34:1738–1745

    PubMed  Google Scholar 

  • Hormann C, Baum M, Luz G, Putensen C, Putz G (1992) Tidal volume, breathing frequency, and oxygen consumption at different pressure support levels in the early stage of weaning in patients without chronic obstructive pulmonary disease. Intens Care Med 18:226–230

    CAS  Google Scholar 

  • Hunter JD (2006) Ventilator associated pneumonia. Postgrad Med J 82:172–178

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hurford WE, Favorito F (1995) Association of myocardial ischemia with failure to wean from mechanical ventilation. Crit Care Med 23:1475–1480

    CAS  PubMed  Google Scholar 

  • Jolliet P, Abajo B, Pasquina P, Chevrolet JC (2001) Non-invasive pressure support ventilation in severe community-acquired pneumonia. Intens Care Med 27:812–821

    CAS  Google Scholar 

  • Kollef MH, Shapiro SD, Silver P, St JRE, Prentice D, Sauer S, Ahrens TS, Shannon W, Baker-Clinkscale D (1997) A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation. Crit Care Med 25:567–574

    CAS  PubMed  Google Scholar 

  • Kress JP, Pohlman AS, O’Connor MF, Hall JB (2000) Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 342:1471–1477

    CAS  PubMed  Google Scholar 

  • Kress JP, Hall JB (2006) Sedation in the mechanically ventilated patient. Crit Care Med 34:2541–2546

    PubMed  Google Scholar 

  • Kuiper JW, Groeneveld AB, Slutsky AS, Plotz FB (2005) Mechanical ventilation and acute renal failure. Crit Care Med 33:1408–1415

    PubMed  Google Scholar 

  • Laffey JG, O’Croinin D, McLoughlin P, Kavanagh BP (2004) Permissive hypercapnia--role in protective lung ventilatory strategies. Intens Care Med 30:347–356

    Google Scholar 

  • Laghi F, D’Alfonso N, Tobin MJ (1995) Pattern of recovery from diaphragmatic fatigue over 24 hours. J Appl Physiol 79:539–546

    CAS  PubMed  Google Scholar 

  • Lellouche F, Mancebo J, Jolliet P, Roeseler J, Schortgen F, Dojat M, Cabello B, Bouadma L, Rodriguez P, Maggiore S, Reynaert M, Mersmann S, Brochard L (2006) A multicenter randomized trial of computer-driven protocolized weaning from mechanical ventilation. Am J Respir Crit Care Med 174:894–900

    PubMed  Google Scholar 

  • Lemaire F, Teboul JL, Cinotti L, Giotto G, Abrouk F, Steg G, quin-Mavier I, Zapol WM (1988) Acute left ventricular dysfunction during unsuccessful weaning from mechanical ventilation. Anesthesiology 69:171–179

    CAS  PubMed  Google Scholar 

  • Leung P, Jubran A, Tobin MJ (1997) Comparison of assisted ventilator modes on triggering, patient effort, and dyspnea. Am J Respir Crit Care Med 155:1940–1948

    CAS  PubMed  Google Scholar 

  • Lin M, Yang YF, Chiang HT, Chang MS, Chiang BN, Cheitlin MD (1995) Reappraisal of continuous positive airway pressure therapy in acute cardiogenic pulmonary edema. Short-term results and long-term follow-up. Chest 107:1379–1386

    CAS  PubMed  Google Scholar 

  • Lionetti V, Recchia FA, Ranieri VM (2005) Overview of ventilator-induced lung injury mechanisms. Curr Opin Crit Care 11:82–86

    PubMed  Google Scholar 

  • Lowe GJ, Ferguson ND (2006) Lung-protective ventilation in neurosurgical patients. Curr Opin Crit Care 12:3–7

    PubMed  Google Scholar 

  • MacIntyre NR (2005) Current issues in mechanical ventilation for respiratory failure. Chest 128:561S–567S

    PubMed  Google Scholar 

  • Marelich GP, Murin S, Battistella F, Inciardi J, Vierra T, Roby M (2000) Protocol weaning of mechanical ventilation in medical and surgical patients by respiratory care practitioners and nurses: effect on weaning time and incidence of ventilator-associated pneumonia. Chest 118:459–467

    CAS  PubMed  Google Scholar 

  • Marini JJ, Rodriguez RM, Lamb V (1986) The inspiratory workload of patient-initiated mechanical ventilation. Am Rev Respir Disease 134:902–909

    CAS  Google Scholar 

  • Masip J, Roque M, Sanchez B, Fernandez R, Subirana M, Exposito JA (2005) Noninvasive ventilation in acute cardiogenic pulmonary edema: systematic review and meta-analysis. JAMA 294:3124–3130

    CAS  PubMed  Google Scholar 

  • Meade M, Guyatt G, Cook D, Griffith L, Sinuff T, Kergl C, Mancebo J, Esteban A, Epstein S (2001) Predicting success in weaning from mechanical ventilation. Chest 120:400S–424S

    CAS  PubMed  Google Scholar 

  • Meade MO, Cook DJ, Guyatt GH, Slutsky AS, Arabi YM, Cooper DJ, Davies AR, Hand LE, Zhou Q, Thabane L, Austin P, Lapinsky S, Baxter A, Russell J, Skrobik Y, Ronco JJ, Stewart TE (2008) Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 299:637–645

    CAS  PubMed  Google Scholar 

  • Mercat A, Richard JC, Vielle B, Jaber S, Osman D, Diehl JL, Lefrant JY, Prat G, Richecoeur J, Nieszkowska A, Gervais C, Baudot J, Bouadma L, Brochard L (2008) Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 299:646–655

    CAS  PubMed  Google Scholar 

  • Moerer O, Hahn G, Quintel M (2011) Lung impedance measurements to monitor alveolar ventilation. Curr Opin Crit Care 17(3):260–267

    PubMed  Google Scholar 

  • Nava S, Ambrosino N, Clini E, Prato M, Orlando G, Vitacca M, Brigada P, Fracchia C, Rubini F (1998) Noninvasive mechanical ventilation in the weaning of patients with respiratory failure due to chronic obstructive pulmonary disease. A randomized, controlled trial. Ann Intern Med 128:721–728

    CAS  PubMed  Google Scholar 

  • Neumann P, Wrigge H, Zinserling J, Hinz J, Maripuu E, Andersson LG, Putensen C, Hedenstierna G (2005) Spontaneous breathing affects the spatial ventilation and perfusion distribution during mechanical ventilatory support. Crit Care Med 33:1090–1095

    PubMed  Google Scholar 

  • Park M, Sangean MC, Volpe MS, Feltrim MI, Nozawa E, Leite PF, Passos Amato MB, Lorenzi-Filho G (2004) Randomized, prospective trial of oxygen, continuous positive airway pressure, and bilevel positive airway pressure by face mask in acute cardiogenic pulmonary edema. Crit Care Med 32:2407–2415

    PubMed  Google Scholar 

  • Parsons PE, Eisner MD, Thompson BT, Matthay MA, Ancukiewicz M, Bernard GR, Wheeler AP (2005) Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med 33:1–6

    CAS  PubMed  Google Scholar 

  • Peigang Y, Marini JJ (2002) Ventilation of patients with asthma and chronic obstructive pulmonary disease. Curr Opin Crit Care 8:70–76

    PubMed  Google Scholar 

  • Pinhu L, Whitehead T, Evans T, Griffiths M (2003) Ventilator-associated lung injury. Lancet 361:332–340

    PubMed  Google Scholar 

  • Pinsky MR (2005) Cardiovascular issues in respiratory care. Chest 128:592S–597S

    PubMed  Google Scholar 

  • Plant PK, Owen JL, Elliott MW (2000) Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial. Lancet 355:1931–1935

    CAS  PubMed  Google Scholar 

  • Putensen C, Mutz NJ, Putensen-Himmer G, Zinserling J (1999) Spontaneous breathing during ventilatory support improves ventilation-perfusion distributions in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 159:1241–1248

    CAS  PubMed  Google Scholar 

  • Putensen C, Zech S, Wrigge H, Zinserling J, Stuber F, Mutz N (2001) Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury. Am J Respir Crit Care Med 164:43–49

    CAS  PubMed  Google Scholar 

  • Putensen C, Muders T, Varelmann D, Wrigge H (2006a) The impact of spontaneous breathing during mechanical ventilation. Curr Opin Crit Care 12:13–18

    PubMed  Google Scholar 

  • Putensen C, Wrigge H, Hering R (2006b) The effects of mechanical ventilation on the gut and abdomen. Curr Opin Crit Care 12:160–165

    PubMed  Google Scholar 

  • Ram FS, Picot J, Lightowler J, Wedzicha JA (2004) Non-invasive positive pressure ventilation for treatment of respiratory failure due to exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev CD004104

    Google Scholar 

  • Ranieri VM, Suter PM, Tortorella C, De TR, Dayer JM, Brienza A, Bruno F, Slutsky AS (1999) Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 282:54–61

    CAS  PubMed  Google Scholar 

  • Rodriguez-Roisin R (2006) COPD exacerbations. 5: management. Thorax 61:535–544

    CAS  PubMed Central  PubMed  Google Scholar 

  • Rumbak MJ, Newton M, Truncale T, Schwartz SW, Adams JW, Hazard PB (2004) A prospective, randomized, study comparing early percutaneous dilational tracheotomy to prolonged translaryngeal intubation (delayed tracheotomy) in critically ill medical patients. Crit Care Med 32:1689–1694

    PubMed  Google Scholar 

  • Sakr Y, Vincent JL, Reinhart K, Groeneveld J, Michalopoulos A, Sprung CL, Artigas A, Ranieri VM (2005) High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury. Chest 128:3098–3108

    PubMed  Google Scholar 

  • Samodelov LF, Falke KJ (1988) Total inspiratory work with modern demand valve devices compared to continuous flow CPAP. Intens Care Med 14:632–639

    CAS  Google Scholar 

  • Sassoon CS, Mahutte CK (1993) Airway occlusion pressure and breathing pattern as predictors of weaning outcome. Am Rev Respir Disease 148:860–866

    CAS  Google Scholar 

  • Schönhofer B, Kuhlen R, Neumann P, Westhoff M, Berndt C, Sitter H (2008) Non-invasive mechanical ventilation in acute respiratory failure. Pneumologie 62:449–479

    PubMed  Google Scholar 

  • Shapiro M, Wilson RK, Casar G, Bloom K, Teague RB (1986) Work of breathing through different sized endotracheal tubes. Crit Care Med 14:1028–1031

    CAS  PubMed  Google Scholar 

  • Shaw MJ (2005) Ventilator-associated pneumonia. Curr Opin Pulm Med 11:236–241

    PubMed  Google Scholar 

  • Slutsky AS (1994a) Consensus conference on mechanical ventilation--January 28–30, 1993 at Northbrook, Illinois, USA. Part 1. Intens Care Med 20:65–79

    Google Scholar 

  • Slutsky AS (1994b) Consensus conference on mechanical ventilation--January 28–30, 1993 at Northbrook, Illinois, USA. Part 2. Intens Care Med 20:150–162

    CAS  Google Scholar 

  • Tappy L, Schwarz JM, Schneiter P, Cayeux C, Revelly JP, Fagerquist CK, Jequier E, Chiolero R (1998) Effects of isoenergetic glucose-based or lipid-based parenteral nutrition on glucose metabolism, de novo lipogenesis, and respiratory gas exchanges in critically ill patients. Crit Care Med 26:860–867

    CAS  PubMed  Google Scholar 

  • Terragni PP, Rosboch G, Tealdi A, Corno E, Menaldo E, Davini O, Gandini G, Herrmann P, Mascia L, Quintel M, Slutsky AS, Gattinoni L, Ranieri VM (2007) Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med 175:160–166

    CAS  PubMed  Google Scholar 

  • The Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–130

    Google Scholar 

  • Vieillard-Baron A, Jardin F (2003) Why protect the right ventricle in patients with acute respiratory distress syndrome? Curr Opin Crit Care 9:15–21

    PubMed  Google Scholar 

  • Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. NEnglJMed 342:1334–1349

    CAS  PubMed  Google Scholar 

  • Windisch W, Brambring J, Budweiser S, Dellweg D, Geiseler J, Gerhard F, Köhnlein T, Mellies U, Schönhofer B, Schucher B, Siemon K, Walterspacher S, Winterholler M, Sitter H, Projektgruppe Nichtinvasive und invasive Beatmung als Therapie der chronischen respiratorischen Insuffizienz (2010) Nichtinvasive und invasive Beatmung als Therapie der chronischen respiratorischen Insuffizienz S2-Leitlinie herausgegeben von der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V. Pneumologie 64:207–240

    CAS  PubMed  Google Scholar 

  • Yang KL, Tobin MJ (1991) A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation. N Engl J Med 324:1445–1450

    CAS  PubMed  Google Scholar 

  • Younes M (1992) Proportional assist ventilation, a new approach to ventilatory support. Theory. Am Rev Respir Disease 145:114–120

    CAS  Google Scholar 

  • Younes M, Puddy A, Roberts D, Light RB, Quesada A, Taylor K, Oppenheimer L, Cramp H (1992) Proportional assist ventilation. Results of an initial clinical trial. Am Rev Respir Disease 145:121–129

    CAS  Google Scholar 

  • Younes M, Kun J, Masiowski B, Webster K, Roberts D (2001a) A method for noninvasive determination of inspiratory resistance during proportional assist ventilation. Am J Respir Crit Care Med 163:829–839

    CAS  PubMed  Google Scholar 

  • Younes M, Webster K, Kun J, Roberts D, Masiowski B (2001b) A method for measuring passive elastance during proportional assist ventilation. Am J Respir Crit Care Med 164:50–60

    CAS  PubMed  Google Scholar 

  • Young D, Lamb SE, Shah S, MacKenzie I, Tunnicliffe W, Lall R, Rowan K, Cuthbertson BH, OSCAR Study Group (2013) High-frequency oscillation for acute respiratory distress syndrome. N Engl J Med 368:806–813

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bickenbach, J., Dembinski, R. (2015). Maschinelle Beatmung und Entwöhnung von der Beatmung. In: Marx, G., Muhl, E., Zacharowski, K., Zeuzem, S. (eds) Die Intensivmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54953-3_26

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-54953-3_26

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54952-6

  • Online ISBN: 978-3-642-54953-3

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics