Nomenclature
EC number
1.14.19.6
Systematic name
acyl-CoA,hydrogen donor:oxygen Δ12-oxidoreductase
Recommended name
Δ12-fatty-acid desaturase
Synonyms
Δ12Des <29> [28]
Δ12 desaturase <7,15> [21,29]
Δ12 fatty acid desaturase <1,12,17> [25,27,32]
Δ12 oleate hydroxylase <4> (<4> shows Δ12 desaturase activities on 16C and
18C monounsaturated fatty acids [26]) [26]
Δ12(ω6)-desaturase <11> [13]
Δ12-FAD <25> [22]
Δ12-desaturase <29> [28]
Δ12-desaturase system | <3> (<3> enzymatic complex [9]) [9]
Δ12-fatty acid desaturase <15,25> [5,22]
Δ12-fatty acyl-CoA desaturase <11> [13]
Δ12DS <24> (<24> bifunctional enzyme with strong Δ12 and low D15 desaturase
activities [16]) [16]
FAD2 <5,10,12,17,28,30> (<10> Δ12 fatty acid desaturase 2 [15])
[15,24,27,30,31,32]
FAH <4> [26]
Fm2 <23> [18]
KlFAD2 <12> [20]
Le-FAD2 <21> [17]
PtFAD2 <11> [13]
PtFAD6 <11> [13]
Δ12 fatty acid desaturases <28> [24]
Δ12 fatty acid desaturase <30> [30]
fatty acid desaturase-2 <5> [31]
oleoyl coenzyme A desaturase <11> [13]
oleoyl-CoA Δ12 desaturase <11> [13]
oleoyl-Δ12 desaturase <26> [23]
oleoyl-Δ12/linoleoyl-Δ3 desaturase <27> [23]
CAS registry number
84628-81-9
Access provided by Autonomous University of Puebla. Download to read the full chapter text
Chapter PDF
Similar content being viewed by others
Keywords
- Linoleic Acid
- Fatty Acid Desaturase
- Phaeodactylum Tricornutum
- Aspergillus Parasiticus
- Acanthamoeba Castellanii
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Wilson, R.A.; Calvo, A.M.; Chang, P.K.; Keller, N.P.: Characterization of the Aspergillus parasiticus Δ12-desaturase gene: A role for lipid metabolism in the Aspergillus-seed interaction. Microbiology, 150, 2881-2888 (2004)
Peyou-Ndi, M.M.; Watts, J.L.; Browse, J.: Identification and characterization of an animal Δ12 fatty acid desaturase gene by heterologous expression in Saccharomyces cerevisiae. Arch. Biochem. Biophys., 376, 399-408 (2000)
Borgeson, C.E.; De Renobales, M.; Blomquist, G.J.: Characterization of the Δ12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate. Biochim. Biophys. Acta, 1047, 135-140 (1990)
Jurenka, R.A.: Biosynthetic pathway for producing the sex pheromone component (Z,E)-9,12-tetradecadienyl acetate in moths involves a Δ12 desaturase. Cell. Mol. Life Sci., 53, 501-505 (1997)
Sakuradani, E.; Kobayashi, M.; Ashikari, T.; Shimizu, S.: Identification of Δ12-fatty acid desaturase from arachidonic acid-producing Mortierella fungus by heterologous expression in the yeast Saccharomyces cerevisiae and the fungus Aspergillus oryzae. Eur. J. Biochem., 261, 812-820 (1999)
Borgeson, C.E.; Blomquist, G.J.: Subcellular location of the Δ12-desaturase rules out bacteriocyte contribution to linoleate biosynthesis in the house cricket and the American cockroach. Insect Biochem. Mol. Biol., 23, 297-302 (1993)
Avery, S.V.; Lloyd, D.; Harwood, J.L.: Changes in membrane fatty acid composition and Δ12-desaturase activity during growth of Acanthamoeba castellanii in batch culture. J. Eukaryot. Microbiol., 41, 396-401 (1994)
Nugier-Chauvin, C.; Fauconnot, L.; Daligault, F.; Patin, H.: Enantioselective oxidation of thiafatty acids by an algal Δ12-desaturase. J. Mol. Catal. B, 11, 1007-1012 (2001)
Lomascolo, A.; Dubreucq, E.; Galzy, P.: Study of the Δ12-desaturase system of Lipomyces starkeyi. Lipids, 31, 253-259 (1996)
Avery, S.V.; Rutter, A.J.; Harwood, J.L.; Lloyd, D.: Oxygen-dependent low-temperature Δ12 (n6)-desaturase induction and alteration of fatty acid composition in Acanthamoeba castellanii. Microbiology, 142, 2213-2221 (1996)
Sakamoto, T.; Bryant, D.A.: Synergistic effect of high-light and low temperature on cell growth of the Δ12 fatty acid desaturase mutant in Synecho-coccus sp. PCC 7002. Photosynth. Res., 72, 231-242 (2002)
Galle, A.M.; Oursel, A.; Joseph, M.; Kader, J.C.: Solubilization of membrane bound Δ12- and Δ6-fatty acid desaturases from borage seeds. Phytochemistry, 45, 1587-1590 (1997)
Domergue, F.; Spiekermann, P.; Lerchl, J.; Beckmann, C.; Kilian, O.; Kroth, P.G.; Boland, W.; Zahringer, U.; Heinz, E.: New insight into Phaeodactylum tricornutum fatty acid metabolism. Cloning and functional characterization of plastidial and microsomal Δ12-fatty acid desaturases. Plant Physiol., 131, 1648-1660 (2003)
Saeki, K.; Matsumoto, K.; Kinoshita, M.; Suzuki, I.; Tasaka, Y.; Kano, K.; Taguchi, Y.; Mikami, K.; Hirabayashi, M.; Kashiwazaki, N.; Hosoi, Y.; Murata, N.; Iritani, A.: Functional expression of a Δ12 fatty acid desaturase gene from spinach in transgenic pigs. Proc. Natl. Acad. Sci. USA, 101, 6361-6366 (2004)
Fofana, B.; Cloutier, S.; Duguid, S.; Ching, J.; Rampitsch, C.: Gene expression of stearoyl-ACP desaturase and Δ12 fatty acid desaturase 2 is modulated during seed development of flax (Linum usitatissimum). Lipids, 41, 705-712 (2006)
Zhang, S.; Sakuradani, E.; Ito, K.; Shimizu, S.: Identification of a novel bifunctional Δ12/Δ15 fatty acid desaturase from a basidiomycete, Coprinus cinereus TD#822-2. FEBS Lett., 581, 315-319 (2007)
Sakai, H.; Kajiwara, S.: Cloning and functional characterization of a Δ12 fatty acid desaturase gene from the basidiomycete Lentinula edodes. Mol. Genet. Genomics, 273, 336-341 (2005)
Damude, H.G.; Zhang, H.; Farrall, L.; Ripp, K.G.; Tomb, J.F.; Hollerbach, D.; Yadav, N.S.: Identification of bifunctional Δ12/ω3 fatty acid desaturases for improving the ratio of ω3 to ω6 fatty acids in microbes and plants. Proc. Natl. Acad. Sci. USA, 103, 9446-9451 (2006)
Li, M.C.; Li, H.; Wei, D.S.; Xing, L.J.: Cloning and molecular characterization of Δ12-fatty acid desaturase gene from Mortierella isabellina. World J. Gastroenterol., 12, 3373-3379 (2006)
Kainou, K.; Kamisaka, Y.; Kimura, K.; Uemura, H.: Isolation of Δ12 and ω3- fatty acid desaturase genes from the yeast Kluyveromyces lactis and their heterologous expression to produce linoleic and α-linolenic acids in Saccharomyces cerevisiae. Yeast, 23, 605-612 (2006)
Cipak, A.; Jaganjac, M.; Tehlivets, O.; Kohlwein, S.D.; Zarkovic, N.: Adaptation to oxidative stress induced by polyunsaturated fatty acids in yeast. Biochim. Biophys. Acta, 1781, 283-287 (2008)
Niu, B.; Ye, H.; Xu, Y.; Wang, S.; Chen, P.; Peng, S.; Ou, Y.; Tang, L.; Chen, F.: Cloning and characterization of a novel Δ12-fatty acid desaturase gene from the tree Sapium sebiferum. Biotechnol. Lett., 29, 959-964 (2007)
Hoffmann, M.; Hornung, E.; Busch, S.; Kassner, N.; Ternes, P.; Braus, G.H.; Feussner, I.: A small membrane-peripheral region close to the active center determines regioselectivity of membrane-bound fatty acid desaturases from Aspergillus nidulans. J. Biol. Chem., 282, 26666-26674 (2007)
Kargiotidou, A.; Deli, D.; Galanopoulou, D.; Tsaftaris, A.; Farmaki, T.: Low temperature and light regulate Δ12 fatty acid desaturases (FAD2) at a transcriptional level in cotton (Gossypium hirsutum). J. Exp. Bot., 59, 2043-2056 (2008)
Yin, D.; Cui, D.; Jia, B.: Construction of a high-efficient expression vector of Δ12 fatty acid desaturase in peanut and its prokaryotical expression. J. Genet. Genomics, 34, 81-88 (2007)
Meesapyodsuk, D.; Qiu, X.: An oleate hydroxylase from the fungus Claviceps purpurea: cloning, functional analysis, and expression in Arabidopsis. Plant Physiol., 147, 1325-1333 (2008)
Oura, T.; Kajiwara, S.: Substrate specificity and regioselectivity of Δ12 and ω3 fatty acid desaturases from Saccharomyces kluyveri. Biosci. Biotechnol. Biochem., 72, 3174-3179 (2008)
Zhou, X.R.; Horne, I.; Damcevski, K.; Haritos, V.; Green, A.; Singh, S.: Isolation and functional characterization of two independently-evolved fatty acid Δ12-desaturase genes from insects. Insect Mol. Biol., 17, 667-676 (2008)
Sakuradani, E.; Abe, T.; Matsumura, K.; Tomi, A.; Shimizu, S.: Identification of mutation sites on Δ12 desaturase genes from Mortierella alpina 1S-4 mutants. J. Biosci. Bioeng., 107, 99-101 (2009)
Zhang, D.; Pirtle, I.L.; Park, S.J.; Nampaisansuk, M.; Neogi, P.; Wanjie, S.W.; Pirtle, R.M.; Chapman, K.D.: Identification and expression of a new Δ12 fatty acid desaturase (FAD2-4) gene in upland cotton and its functional expression in yeast and Arabidopsis thaliana plants. Plant Physiol. Biochem., 47, 462-471 (2009)
Chen, Q.; Liu, Q.; Wu, Z.; Wang, Z.; Gou, K.: Generation of fad2 transgenic mice that produce ω-6 fatty acids. Sci. China C Life Sci., 52, 1048-1054 (2009)
Yazawa, H.; Iwahashi, H.; Kamisaka, Y.; Kimura, K.; Uemura, H.: Production of polyunsaturated fatty acids in yeast Saccharomyces cerevisiae and its relation to alkaline pH tolerance. Yeast, 26, 167-184 (2009)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Schomburg, D., Schomburg, I. (2013). Δ12-fatty-acid desaturase 1.14.19.6. In: Schomburg, D., Schomburg, I. (eds) Class 1 Oxidoreductases. Springer Handbook of Enzymes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36265-1_97
Download citation
DOI: https://doi.org/10.1007/978-3-642-36265-1_97
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-36264-4
Online ISBN: 978-3-642-36265-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)