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An Overview of the Histology of Aging Skin in Laboratory Models

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Textbook of Aging Skin

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Abstract

This article is an overview of histomorphological changes documented during various stages of life in many laboratory models utilized in skin aging studies. A bewildering variety in cutaneous aging response has been observed in different strains. The commonly used laboratory models like the rat and the mouse show dissimilar aging changes in skin. There are a few mouse models which seem to resemble the general trend of skin attrition related to advancing age observed in some human studies. Caloric restriction has been observed to modulate skin aging changes in the rat and the mouse. Despite the wide variation in observational studies related to aging changes, some rodent models are useful to aging research and experimental response of aging skin.

“What lies beneath this aging skin? The untold destruction stealthy creeping, The bones the organs the nerves, the brain, I am breathing, I am functioning, Am I living?”

Julie A. Crippin, 2008

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Acknowledgment

The kind support and encouragement provided by Dr. Regan Thomas, MD, Chairman, Department of Otolaryngology – Head and Neck Surgery, UIC, is greatly appreciated. Some of the cited work was partly supported by the Bernstein Grant from the AAFPRS Foundation.

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Authors and Affiliations

  1. Otolaryngology-Head & Neck Surgery, University of Illinois, Chicago, IL, USA

    Tapan K. Bhattacharyya

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  1. Tapan K. Bhattacharyya
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Correspondence to Tapan K. Bhattacharyya .

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Editors and Affiliations

  1. Procter & Gamble Co., Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Procter & Gamble Co., Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department Dermatology, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Howard I. Maibach

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Bhattacharyya, T.K. (2015). An Overview of the Histology of Aging Skin in Laboratory Models. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27814-3_1-2

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  • DOI: https://doi.org/10.1007/978-3-642-27814-3_1-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27814-3

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