Abstract
Piriformis syndrome is mainly a clinical diagnosis of exclusion. Patients present with gluteal pain in the sciatic nerve distribution, which is due to an overlying tight piriformis muscle. Common special exam findings include the piriformis sign, FAIR, Lasegue, and Beatty. Imaging and electromyography (EMG) and nerve conduction studies (NCS) can help rule out anatomical abnormalities. Physical therapy, manipulation, and complementary alternative modalities, such as yoga and acupuncture, are aimed at relaxing the tight piriformis. Injection of local anesthetics, steroids, and botulinum toxin can serve to diagnose and treat. If your patient has neurological deficits or imaging reveals an anatomical variance or a mass, consider an outside referral.
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Keywords
- Piriformis syndrome
- FAIR
- Lasegue
- Piriformis sign
- Low back pain
- Myofascial pain syndromes
- Sciatica
- Botulinum toxin
- H-reflex
Definition
Piriformis syndrome is a buttock pain caused by compression of the sciatic nerve by a tight piriformis muscle. It is a constellation of symptoms including gluteal pain with possible lower extremity radiation, numbness, and tingling. It usually does not present with weakness or sensory loss, except in chronic conditions. The syndrome should not be confused by piriformis-mediated muscle pain, SI joint pain, or lumbar radiculopathy.
Piriformis syndrome comes in two types, primary and secondary [1]:
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Primary: due to anatomic variation, such as a split sciatic nerve, a split piriformis muscle, or an anomalous sciatic nerve path. Fewer than 15% of cases are known to have primary causes.
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Secondary: due to a known cause, including trauma, mass effect, and local ischemia. Gait abnormalities can accentuate this.
Diagnosis
Piriformis syndrome continues to be a controversial diagnosis for sciatic pain. Some authors believe it is underdiagnosed; others believe it is overdiagnosed [2, 3]. Piriformis syndrome is based on history and physical exam, including special testing such as piriformis sign, FAIR, Beatty, and Lasegue sign. Correlation of provocative tests with abnormal piriformis morphology has been attempted, but resulted in an inability to create a criterion standard to diagnosis piriformis syndrome [4]. Imaging is used to identify anatomical variants and to rule out other pathologies. EMG exam is often normal, although Fishman et al. propose that a prolonged H-reflex (mean 1.87) in the affected lower extremity is associated with piriformis syndrome [5].
History
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1928: Yeoman reported that periarthritis involving the anterior sacroiliac ligament, the piriformis muscle, and branches of the sciatic nerve may be contributors of sciatica [6].
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1934: Friedberg and Vinke believed that inflammation of the sacroiliac joint may cause a reaction of the piriformis muscle and its fascia, as well as irritation of the lumbosacral plexus [7].
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1938: Beaton and Anson hypothesized that the spasm of the piriformis muscle could irritate the sciatic nerve [8].
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1947: Robinson first coined the term “piriformis syndrome” and emphasized the necessity to rule out other causes of sciatica. The six features he described: history of trauma to the buttock, gluteal or sacroiliac pain radiating down the leg, often limiting ambulation, gluteal atrophy, palpable sausage-shaped mass, and positive Lasegue sign [9].
Differential Diagnosis
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Spinal: lumbosacral disc pathology with radiculopathy, facet arthropathy, sacroiliac (SI) joint arthropathy, spinal stenosis, and spondylolysis
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Hip pathology: osteoarthritis, labral tear, femoral-acetabular impingement (FAI), and greater trochanteric pain syndrome
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Muscles: hamstring strain and lumbar muscular strain
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Nerve: radiculopathy, pudendal neuralgia, posterior femoral cutaneous neuralgia, and inferior cluneal neuralgia
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Sciatic neuropathy of other cause: tumor, infection, hematoma, aneurysm, and endometriosis
Epidemiology
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Prevalence varies widely, depending on the diagnostic criteria used and the characteristics of the sample population [1]. A 2013 prospective study (2,910 patients) of the prevalence of piriformis syndrome among the cases of low back/buttock pain with sciatica showed that the prevalence is 6.25%. Females are more affected than males. Right side affected more than left [10].
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Etiology and associations: more common – overuse, prolonged sitting, trauma, and vigorous massage [10]. Less common – bilateral THR [11], leg length discrepancy [12, 13], endometriosis [14], pregnancy [15], accessory piriformis muscle [16], and atorvastatin [17]
Anatomy
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The piriformis muscle originates from the anterior border of the sacrum and attaches to the superior margin of the greater trochanter. It is the only muscle that transverses the sciatic notch. Numerous nerves and vessels that pass from the pelvis to the gluteal region come posteriorly above or below this muscle, which is innervated by ventral rami of S1 and S2 (Fig. 51.1) [18].
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The sciatic nerve may exit the pelvis into the gluteal region by six different routes [19]. These anatomic variations of the sciatic nerve may be associated with a higher incidence of piriformis syndrome, but more recent studies have shown this may not be the case (Fig. 51.2) [20].
Imaging and EMG
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Imaging such as MRI, CT, and ultrasound is used to view anatomical variants, spinal pathologies, nerve compression, joint abnormalities, and tumors. Hip or pelvic MRI is not sensitive in diagnosing piriformis syndrome [19].
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MR neurography and interventional MR imaging can reveal piriformis muscle asymmetry and sciatic nerve hyperintensity at the sciatic notch, differentiating patients with piriformis syndrome from those without who had similar symptoms (p < 0.01) [22]. To note, the author of this study does have a financial interest in this imaging technology.
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Fishman has shown that patients with piriformis syndrome have a normal electrodiagnostic study, except the ipsilateral prolongation of H-reflex latency greater than 1.86 ms in the affected leg [23]. This has not been reproduced in other studies.
Treatment
See Table 51.2.
When to Refer
See Table 51.3.
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Murakami, M., Kirschner, J. (2017). Piriformis Syndrome. In: Kahn, S., Xu, R. (eds) Musculoskeletal Sports and Spine Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-50512-1_51
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