Abstract
Restoration of functions after trauma or neurological diseases is the major goal of rehabilitation. Technical aids complement remaining functions or even try to replace them completely. Neural prostheses use electrical signals from the nervous system as control signals or excite nerves by means of electrical stimulation to elicit perceptions, induce movements or modulate neural network behavior. Creating novel, neural prostheses applications for the peripheral or central nervous system require neural interfaces and implants that are biocompatible, long-term stable and highly robust. However, only few neural interfaces have been tested or are routinely used in clinical applications today, most of them made with ”old-style” precision mechanics technologies. What are the biological, tech- nological, electrical and material science challenges that must be considered when designing an optimal neural interface? Do nano-, micro- and biohybrid systems have a future in clinical applications of neural implants? Design aspects and opportunities and challenges of miniaturization technologies for neural implants will be presented and discussed for peripheral and central nervous system applications. Devices will be introduced and compared with respect to selectivity, long-term functionality and their applicability in funda- mental and translational research as well as for clinical applications.
Access provided by Autonomous University of Puebla. Download to read the full chapter text
Chapter PDF
Similar content being viewed by others
References
Stieglitz, T.: Neuroprothetik und Neuromodulation – Forschungs- ansätze und klinische Praxis bei Therapie und Rehabilitation. Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz 53(8), 783–790 (2010)
Stieglitz, T., Schuettler, M.: Implant Interfaces. In: Hodgins, D., Inmann, A. (eds.) Intelligent Implantable Sensor Systems for Medical Applications, pp. 39–67. Woodhead Publishing Ltd., Cambridge (2013)
Navarro, X., et al.: A Critical Review of Interfaces with the Peripheral Nervous System for the Control of Neuroprostheses ad Hybrid Bionic Systems. J. Periph. Nerv. Syst. 10(3), 229–258 (2005)
Hassler, C., Boretius, T., Stieglitz, T.: Polymers for Neural Implants. J. Polymer Science-Part B: Polymer Physics 49(1), 18–33 (2011), Erratum in: 49, p. 255 (2011)
Ordonez, J., et al.: Thin-films and microelectrode arrays for neuroprosthetics. MRS Bulletin 37(6), 590–598 (2012)
Stieglitz, T., et al.: Brain-Computer Interfaces: An Overview of the Hardware to Record Neural Signals from the Cortex. Progr. Brain Res. 175, 297–315 (2009)
Raspopovic, S., et al.: Restoring Natural Sensory Feedback in Real- Time Bidirectional Hand Prostheses. Sci. Transl. Med. 6(22), 222ra19 (2014)
Bosman, C., et al.: Stimulus Selection through Selective Synchronization between Money Visual Areas. Neuron 75(5), 875–888 (2012)
Stieglitz, T.: Integration of Microfluidic Capabilities into Micromachined Neural Implants. Int. J.of Micro-Nano Scale Transport 1(2), 139–158 (2010)
Rubehn, B., et al.: A polymer-based microimplant for optogenetic applications: design and first in vivo study. Lab on a chip 13(4), 579–588 (2013)
Stieglitz, T.: Restoration of Neurological Functions by Neuro- prosthetic Technologies: Future Prospects and Trends towards Micro-, Nano- and Biohybrid Systems. In: Sakas, D.E., Simpson, B., Krames, E. (eds.) Operative Neuromodulation. Acta Neurochir. Suppl., vol. 97(1), pp. 435–442. Springer, Wien (2007)
Kim, Y.J., et al.: Genetically engineered bacteriophage delivers an anti-inflammatory peptide coating on neural electrodes. Biomed. Mat. 9, 015009 (2014)
Stieglitz, T.: Manufacturing, Assembling and Packaging of Miniaturized Neural Implants. Microsystem Technol. 16(5), 723–734 (2010)
Guiraud, D., et al.: An Implantable Neuroprostheses for Standing and Walking in Paraplegia: 5 Year Patient Follow Up. J. Neural Eng. 3(4), 268–275 (2006)
Guiraud, et al.: Implanted functional electrical stimulation: case report of a paraplegic patient with complete SCI after 9 years. Journal of NeuroEngineering and Rehabilitation 11, 15 (2014)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer International Publishing Switzerland
About this paper
Cite this paper
Stieglitz, T. (2014). Miniaturized Neural Interfaces and Implants in Neurological Rehabilitation. In: Jensen, W., Andersen, O., Akay, M. (eds) Replace, Repair, Restore, Relieve – Bridging Clinical and Engineering Solutions in Neurorehabilitation. Biosystems & Biorobotics, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-319-08072-7_3
Download citation
DOI: https://doi.org/10.1007/978-3-319-08072-7_3
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-08071-0
Online ISBN: 978-3-319-08072-7
eBook Packages: EngineeringEngineering (R0)