Abstract
Decellularized tissue-derived materials – i.e., biomaterials derived from organs or tissues deprived of their potentially immunogenic cellular components – offer an attractive option for the generation of realistic in vitro tissue and disease models and regenerative therapies. A plethora of decellularization protocols and processing methods make such materials available from numerous tissues and in various formats. This chapter provides an overview of the different forms of tissue-derived decellularized extracellular matrix (dECM) materials for biomedical applications, focusing on innovative dECM-based hydrogels. The chapter concludes with a discussion of the challenges and perspectives of dECM materials concerning standardization and control of physicochemical properties for directing tissue repair and function.
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Magno, V., Werner, C. (2023). Tissue-Derived Decellularized Materials for Biomedical Applications. In: Maia, F.R.A., Oliveira, J.M., Reis, R.L. (eds) Handbook of the Extracellular Matrix . Springer, Cham. https://doi.org/10.1007/978-3-030-92090-6_42-1
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