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Extracellular Matrix Remodeling on Cancer Progression

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Handbook of the Extracellular Matrix

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Abstract

There are various macromolecules that make up the extracellular matrix (ECM). It is composed of proteoglycans, polysaccharides, glycoproteins, and fibrous proteins, which give the ECM its dynamic shape. In terms of tissue development and homeostasis, the ECM plays a major role. In addition, it serves as one of the major structural components of the tumor microenvironment. The ECM undergoes continuous remodeling processes due to the progression of tumors characterized by degradation, deposition, and modification of various ECM components. The purpose of this book chapter is to review the role of ECM remodeling in the development of cancer.

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Acknowledgments

The authors are grateful to the Chettinad Academy of Research and Education for providing the CARE SEED grant (004/Regr./AR-Research/2022-06) and providing PhD fellowship to Deepika B.

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Authors and Affiliations

  1. Medical Bionanotechnology, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kanchipuram, Tamil Nadu, India

    B. Deepika, Agnishwar Girigoswami & Koyeli Girigoswami

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  1. B. Deepika
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  2. Agnishwar Girigoswami
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  3. Koyeli Girigoswami
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Corresponding author

Correspondence to Koyeli Girigoswami .

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Editors and Affiliations

  1. 3B’s Research Group, University of Minho, Barco, Portugal

    Fatima Raquel Azevedo Maia

  2. 3B's Research Group, University of Minho, Guimarães, Portugal

    J. Miguel Oliveira

  3. Dept Polymer Engg, 3Bs Research Grp, University of Minho, Guimaraes, Portugal

    Rui L. Reis

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Deepika, B., Girigoswami, A., Girigoswami, K. (2023). Extracellular Matrix Remodeling on Cancer Progression. In: Maia, F.R.A., Oliveira, J.M., Reis, R.L. (eds) Handbook of the Extracellular Matrix . Springer, Cham. https://doi.org/10.1007/978-3-030-92090-6_10-1

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  • DOI: https://doi.org/10.1007/978-3-030-92090-6_10-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-92090-6

  • Online ISBN: 978-3-030-92090-6

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