Abstract
Phenolic compounds (PC) are a diverse class of phytochemicals that are thought to be among the major responsible for the association between high intake of fruits and vegetables and low risk of chronic diseases. Despite promising protective effects in vitro and in animal models, human studies associating PC intake to beneficial health effects have showed more variable results. The accurate assessment of dietary intake of the different classes of PC is a critical step in epidemiological or intervention studies and biomarkers of PC intake are an alternative to the traditional dietary assessment tools. This chapter focuses on the relation between PC intake and the concentration of PC and their metabolites in body fluids (plasma and urine). The biotransformation of PC during digestive process and their kinetics following exposure, as well as the methods used for estimating dietary intake of PC are also discussed.
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Abbreviations
- BBB:
-
Blood-brain barrier
- CBG:
-
Cytosolic β-glucosidase
- FFQ:
-
Food frequency questionaries
- GC:
-
Gas chromatography
- HepG2:
-
Hepatocellular carcinoma cell line
- HRMAS:
-
High-resolution magic angle spinning
- LC:
-
Liquid chromatography
- LPH:
-
Lactase-phlorizin hydrolase
- MCT:
-
Monocarboxylic acid transporter
- MS:
-
Mass spectrometry analyzer
- NMR:
-
Nuclear magnetic resonance spectroscopy
- ODMA:
-
O-desmethylangolensin
- PC:
-
Phenolic compounds
- SGLT1:
-
Sodium-glucose-linked transporter 1
- UDP:
-
Uridine diphosphate
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Augusti, P.R. et al. (2022). Biological Markers of Plant Phenolic Compounds Intake. In: Patel, V.B., Preedy, V.R. (eds) Biomarkers in Nutrition . Biomarkers in Disease: Methods, Discoveries and Applications. Springer, Cham. https://doi.org/10.1007/978-3-030-81304-8_60-1
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