Abstract
The process of sulfation of galactomannan of herbaceous plants with complex of sulfamic acid and urea, was optimized. The influence of varying factors was established - the ratio of sulfamic acid: urea (SAA: U), the ratio of galactomannan: sulfating complex (GM: SC) and the duration of the process on the degree of substitution in the obtained galactomannan sulfate. The data of analysis of variance for the obtained mathematical models indicate good prognostic properties. The optimal conditions for galactomannan sulfation, which provide water-soluble sulfated galactomannan with a high (0.89) degree of substitution, have been established. The optimal conditions for the process of sulfation of galactomannan of herbaceous plants amount of urea (mol) per 1 mol of SAA – 2.26 mol, amount of SC (mol) per 1 mol of GM – 3.9 mol and process time – 118 min. Sulfated galactomannan of herbaceous plants can be used as a substitute for animal-derived anticoagulant heparin.
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The reported study was funded by RFBR, project number 20-33-70256.
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Kazachenko, A.S., Vasilyeva, N.Y., Malyar, Y.N. (2020). Numerical Optimization of the Galactomannan Sulfation Process with a Sulfamic Acid-Urea Complex. In: Silhavy, R., Silhavy, P., Prokopova, Z. (eds) Software Engineering Perspectives in Intelligent Systems. CoMeSySo 2020. Advances in Intelligent Systems and Computing, vol 1295. Springer, Cham. https://doi.org/10.1007/978-3-030-63319-6_52
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