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Mechanisms of Action of Different Bariatric Surgical Procedures

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Obesity, Bariatric and Metabolic Surgery

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Abstract

Bariatric and metabolic surgery can effectively induce durable weight loss and can reduce the risk of obesity-associated complications, including type 2 diabetes mellitus (T2DM). Bariatric procedures fundamentally alter physiology, and in those with diabetes, bariatric and metabolic surgery can often result in remission of diabetes by affecting insulin sensitivity and insulin secretion.

The action of each procedure differs, and the mechanisms by which each procedure produces weight loss and alters physiological systems, such as glucose homeostasis, are multiple and often integrated. The known mechanisms include gut-hormone-mediated changes affecting appetite, insulin dynamics, food preferences, and energy expenditure. In this chapter, we outline the current knowledge on the putative mechanisms of weight loss and glucose homeostasis after the most commonly performed bariatric and metabolic surgical procedures.

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Authors and Affiliations

  1. Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland

    Karl J. Neff

  2. Diabetes Complications Research Centre, Conway Institute, University College Dublin, Dublin, Ireland

    Carel W. le Roux

Authors
  1. Karl J. Neff
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  2. Carel W. le Roux
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Correspondence to Carel W. le Roux .

Editor information

Editors and Affiliations

  1. Homerton University Hospital, London, UK

    Sanjay Agrawal

Section Editor information

  1. Department of Bariatric and Upper GI Surgery, Southmead Hospital, Bristol, UK

    Dimitri J. Pournaras PhD, MRCS

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Neff, K.J., le Roux, C.W. (2023). Mechanisms of Action of Different Bariatric Surgical Procedures. In: Agrawal, S. (eds) Obesity, Bariatric and Metabolic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-60596-4_103

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  • DOI: https://doi.org/10.1007/978-3-030-60596-4_103

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  • Print ISBN: 978-3-030-60595-7

  • Online ISBN: 978-3-030-60596-4

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