Abstract
This chapter describes randomized controlled trials (RCTs) published on the effect of pelvic floor muscle training (PFMT) to treat anatomic pelvic organ prolapse (POP) and symptoms of prolapse. Eleven RCTs have been found and the results show a significant effect of PFMT on both stage of prolapse and symptoms. One research group used ultrasound to assess the position of the bladder and the rectal ampulla at rest, in addition to assessment of morphological changes of the pelvic floor muscles. There was a significant reduction in stage of prolapse, symptoms, bother, and increase in pelvic floor muscle strength. Significant hypertrophy of the pelvic floor muscles, shortening of muscle length, and narrowing of the levator hiatus were found in the treatment group only. The RCTs on PFMT for POP differ in training dosage such as intensity of the contractions, duration of the training period, and therapist contact. These factors are all known to affect outcome. Today there is 1A level of evidence that PFMT is effective in treating POP. Further studies are needed to understand differences between responders and nonresponders and especially the role of PFMT in primary prevention of POP.
Conclusion: There is 1A level evidence for PFMT in treatment of POP and there is no known side effects or complication. PFMT should therefore be first-line treatment.
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Keywords
FormalPara Learning ObjectivesReaders of this chapter should learn about
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Mechanisms of how pelvic floor muscle training can reduce symptoms and improve anatomic pelvic organ prolapse
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The evidence for the effect of pelvic floor muscle training on symptoms of POP and stage of POP
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How to conduct an effective pelvic floor muscle training program for POP
1 Introduction
The prevalence of symptomatic pelvic organ prolapse (POP) is reported to be 3–28% [1,2,3,4,5]. The feeling of vaginal bulge into or out of the vagina is the most common and specific symptom of POP with a prevalence ranging from 5 to 10%. The prevalence increases if pelvic pressure and heaviness are included as symptoms of POP [1, 6, 7], and these symptoms may greatly impair quality of life with restriction of participation in, for example, physical activity. POP may occur in the anterior, middle, and/or posterior compartment of the pelvic floor and it is defined as descent of the anterior vaginal wall (bladder, urethra), posterior vaginal wall (bowel), and/or apex of the vagina (cervix, uterus). Absence of prolapse is defined as stage 0 support; prolapse can be staged from stage I to stage IV (total eversion) [8, 9].
It is estimated that approximately 50% of all women lose some of the supportive mechanisms of the pelvic floor due to childbirth, leading to different degrees of pelvic organ prolapse (POP) [10]. In the UK, POP accounts for 20% of women on waiting lists for major gynecological surgery [11]. Based on databases including more than ten million women in the USA, the lifetime risk of any primary surgery for SUI or POP was 20.0% by the age of 80 years [12]. Prolapse recurs in up to 58% of women after surgery [13], and about one-third of operated women undergo at least one more surgical procedure for prolapse [14]. Stress urinary incontinence, dyspareunia, and mesh exposure are other risk factors associated with surgery [13]. The high prevalence and its increase with age light the need for prevention measures that could reduce the incidence and the impact of POP.
However, prolapse may be asymptomatic until the descending organ is through the introitus, and therefore POP may not be recognized until an advanced condition is present [6, 7]. In some women, the prolapse advances rapidly, while others remain stable for many years. Most clinicians have considered that POP does not seem to regress [10]. However, Handa et al. [15] found that spontaneous regression is common, especially for minor prolapse. This was also confirmed by Miedel et al. [16].
Treatment of POP can be conservative (lifestyle interventions and/or pelvic floor muscle training (PFMT)), mechanical (use of a pessary), or surgical [13, 17]. While systematic reviews and randomized controlled trials (RCTs) have shown convincing effect of PFMT for stress and mixed urinary incontinence [18, 19], the effect on POP is a relatively new area of research. A survey of UK women’s health physical therapists showed that several women attending physical therapy practice presented with a mixture of pelvic floor dysfunctions such as stress urinary incontinence and prolapse and that 92% of the physiotherapists assessed and treated women with POP [20]. The most commonly used treatment was PFMT with and without biofeedback. The aim of the present chapter is to give an up-to-date systematic review of RCTs on PFMT to prevent and treat POP.
2 Methods
The basis for this review is a search on the Cochrane database, PubMed, and the abstract books from the International Continence Society and International Urogynecology Annual Meetings from 2016, for RCTs on PFMT to prevent or treat POP.
3 Results
3.1 In the General Population
Till date, 11 RCTs have been found applying PFMT to treat POP [23,24,25,26,27,28,29,30,31,32,33,32]. Typically most RCTs compared PFMT plus lifestyle intervention, against lifestyle interventions alone. Lifestyle intervention included use of pre-contraction of the PFM before and during increase in intra-abdominal pressure, “the Knack” and advice to avoid pushing down during defecation [24, 25, 28], or general lifestyle advice [23, 28, 29]. None have compared the effect of these lifestyle interventions with untreated controls and there is no report of adherence to these protocols. Hence, the effect of lifestyle interventions on POP is still unknown. Brækken et al. [25] did not find any effect of advice to use the Knack on muscle morphology.
The RCTs are all in favor of PFMT to be effective in treating POP, demonstrating statistically significant improvement in symptoms [24,25,24, 28,29,30,29] and/or prolapse stage [21, 23, 24, 26, 27]. Frawley et al. (2012) and Due et al. (2016) did not find a significant change in stage of POP [28, 32]. Methodological score on PEDro ranged from 4 to 8 with most studies scoring 7–8.
3.1.1 Hypopressive Technique
The hypopressive technique was developed by Caufriez (1997) and involves a combination of a breathing and postural techniques and contraction of the abdominal muscles which has shown to pull the prolapse upward/inward [33]. It remains to be scientific proven whether the hypopressive exercises can reduce intra-abdominal pressure in a way that prevents the pelvic organs to be pushed down and thereby prevent aggravation of POP. However, based on current evidence hypopressive exercise will not increase the strength nor thickness of the PFM muscles. Resende et al. [34] assessed 36 nulliparous physical therapists with vaginal surface EMG during PFM contraction, hypopressive technique, and a combination of the two. They found that PFM contraction was more effective than the hypopressive technique to increase sEMG activation of the PFM and that there were no additional effects of adding the hypopressive technique. Not surprisingly, the hypopressive technique was significantly more effective than PFM contraction in activation of the transverse abdominal muscle. In an RCT, Stupp et al. (2011) found that both PFMT and PFMT + the hypopressive technique were significantly more effective than lifestyle advice in increasing muscle strength (Oxford grading) and muscle activation (sEMG), but there was no additional effect of adding the hypopressive technique to PFMT [26]. Ultrasound assessment of the cross-sectional area (CSA) of the levator ani muscle showed increased CSA in the PFMT and the PFMT + hypopressive technique compared to the lifestyle group, but there was no additional effect of the hypopressive technique on CSA [35].
3.2 FMT to Prevent and Treat POP in the Peripartum Period
We have only been able to find one RCT evaluating the effect of PFMT to prevent and treat POP after childbirth [36]. In a group of 175 first-time mothers stratified on major levator ani injury and randomized to either PFMT or control, no effect was shown either on prevention or treatment of POP. The intervention lasted 4 months and the participants had been taught correct PFM contraction by an experienced physical therapist. The training consisted of group training once a week and daily home training with three sets of 8–12 close to maximum contractions. It was concluded that individual and more intensive training may be necessary, especially if there are major injuries. Further studies are needed to address whether PFMT can restore injured muscles and treat POP in postpartum women.
3.3 Prevention
The most important goal would be to prevent POP from occurring in the first place. However, primary prevention studies are difficult, or almost impossible, to conduct. It is not feasible or ethical to randomize women to PFMT or control and follow them for 30–40 years, which would have been the optimal design to answer this research question. No RCTs or studies using other designs have been found in evaluating the effect of PFMT on POP in primary prevention (stop prolapse from developing). Only one prevention study has been found [37]. Four hundred and seven women, not seeking treatment, but still with POP symptoms, were followed for 2 years with a program of two sessions of week with Pilates training, including isolated PFM contractions. The results showed that there were significantly less report of POP symptoms in the PFMT group compared to the controls. Given that it is unlikely to have high-quality studies in this area, one could argue from theory and studies showing that women with POP have weaker PFM than healthy controls [37] and that PFMT has shown to lift the bladder neck and the rectal ampulla, narrowing the levator hiatus, reduce PFM length and increase PFM cross-sectional area [25] that it is plausible that PFMT can prevent POP in women. However, to date there is no evidence for this proposal. Based on an understanding of functional anatomy and exercise science, we recommend that general exercise programs for women should include PFMT.
3.4 PFMT in Combination with Surgery
PFMT has shown to be effective in reducing symptoms and improve stage of POP. Women should be offered PFMT as a first choice treatment for prolapse, before surgery [17]. Most surgeons would also recommend to continue to do PFMT after surgery to prevent relapse and to improve PFM function. To date there are only few RCTs assessing the effect of PFMT in combination with surgery [41,42,43,44,42]. Only one of these studies showed a positive additional effect [42].
However, this is a feasibility study with a small sample size, and the results must be interpreted with caution. Recent systematic reviews have concluded that there is insufficient evidence to conclude whether PFMT has any additional effect to surgical repair of POP [17, 42, 43]. One reason for the lack of effect may be that the follow-up period has been too short to show effect on relapse. And in addition, such expected long-term effects involve that the women continue to perform PFMT regularly for many years.
3.5 Long-Term Effect
To date, there is only one abstract reporting long-term effect of PFMT for POP. Hagen et al. [44] reported a 2-year follow-up after PFMT. Unfortunately, only 40% of the original 447 participants responded. There was no longer any difference between the training and control group in Pelvic Organ Prolapse Symptom Score, but fewer women in the PFMT group opted for further treatment and 6% in the PFMT group had surgery vs. 13% in the control group. Further and longer follow-up trials are needed in this area. However, long-term studies imply strict adherence to the training program to allow for meaningful interpretations of results.
4 Discussion
The conclusion from 11 RCTs and systematic reviews are consistent that there is strong evidence that PFMT is effective in reducing POP symptoms and improves stage of POP.
The published studies only reported short-term effects. To maintain the effect, similar to the recommendations for general strength training, it is expected that PFMT must be continued, although with a reduced frequency of training, to avoid relapse [45].
There are two main hypotheses for mechanisms as to how PFMT may be effective in prevention and treatment of stress urinary incontinence [46, 47], and the same theories may apply for a possible effect of PFMT to prevent and treat POP.
The two hypotheses are as follows: (1) women learn to consciously contract before and during increases in abdominal pressure (also termed “bracing” or “performing the Knack”) and continue to perform such contractions as a behavior modification to prevent descent of the pelvic organs and pelvic floor muscles; and (2) women are taught to perform regular strength training in order to build up “stiffness” and structural support of the pelvic floor over time [45].
4.1 Conscious Contraction (Bracing or “Performing the Knack”) to Prevent and Treat POP
Research on basic and functional anatomy supports conscious contraction of the PFM as an effective maneuver to stabilize the pelvic floor [48, 49]. However, to date, there are neither studies on how much strength or which neuromotor control strategies are necessary to prevent descent during cough and other physical exertions nor how to prevent gradual descent due to activities of daily living. Brækken et al. (2010) found that advice to do “the Knack” and not to strain on defecation improved stage of POP in 4% [24], but no morphological changes of the PFM were found after this training modality [25].
An interesting, but difficult, hypothesis to test is whether women at risk for POP can prevent development of prolapse by performing bracing or “the Knack” during a rise in intra-abdominal pressure. Since it is possible to learn to hold a hand over the mouth before and during coughing, one would expect that it is possible to learn to precontract the PFM before and during simple and single tasks such as coughing, lifting, and isolated exercises such as performing abdominal exercises. However, multiple task activities and repetitive movements such as running, playing tennis, aerobics, and dance activities cannot be conducted with intentional co-contractions of the PFM.
4.2 Strength Training
The theoretical rationale for intensive strength training of the PFM to treat POP is that strength training may build up the structural support of the pelvis by:
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Elevating the levator plate to a permanently higher location inside the pelvis
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Enhancing hypertrophy and increased stiffness of the PFM and connective tissue, reducing muscle length of the puborectalis, narrowing the levator hiatus
As described by DeLancey [50] in the “boat in dry dock” theory, the connective tissue support of the pelvic organs fails if the PFM relax or are damaged, and organ descent occurs. This underpins the concept of elevation of the PFM and closure of the levator hiatus as important elements in conservative management of POP. All the RCTs in this area have used strength training principles in the treatment protocols. However, Brækken et al. [24] measured PFM strength increase in both randomized arms. They found a significant and huge increase in strength in the PFMT group only. They also found statistically significant increases in muscle volume, shortening of the muscle length, narrowing of the levator hiatus, and lifting of the bladder neck and rectal ampulla [25], factors that may be essential in prevention and reversion of POP.
Readers may learn more about how to perform an effective PFMT program by watching www.Corewellness.
5 Conclusions
To date there is strong evidence that PFMT can significantly reduce symptoms and improve stage of POP. Further studies are needed to address which women respond to training and if POP can be prevented. A suggested primary prevention strategy for the general female population would be to avoid straining, to learn to contract the PFM during an increase in intra-abdominal pressure, and to conduct regular strength training of the PFM.
Take-Home Message
PFMT has 1A evidence to be effective in treating POP and there are no known side effects or complications. Women with POP stage I, II, and III should be offered PFMT as first-line treatment.
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Bø, K., Brækken, I.H. (2021). Pelvic Floor Muscle Training in Prevention and Treatment of Pelvic Organ Prolapse. In: Santoro, G.A., Wieczorek, A.P., Sultan, A.H. (eds) Pelvic Floor Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-40862-6_52
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