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Langerhans Cell Histiocytosis

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Evidence-Based Imaging in Pediatrics

Part of the book series: Evidence-Based Imaging ((Evidence-Based Imag.))

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Abstract

Histiocytoses are rare disorders characterized by the pathological proliferation of monocyte and macrophage lineages, of which Langerhans’ cell histiocytosis (LCH) is the most common [1, 2]. Historically, the classification and naming of histiocytic disorders, including LCH, has been challenging due to the variety of clinical presentations which are a function of which organ system(s) have been invaded by the pathological cells. Presentation ranges from a self-limiting skin rash to fulminant multisystem disease with high mortality [3]. Previously described eponyms associated with particular presentations of LCH, such as eosinophilic granuloma, Hand-Schüller-Christian, and Letterer-Siwe disease, are of historical interest but should be disregarded in clinical practice [4]. In 1987, the Writing Group of the Histiocytosis Society proposed that Histiocytosis X be reclassified as LCH, the currently accepted term [5].

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Author information

Authors and Affiliations

  1. Division of Pediatric Radiology, Department of Radiology, NYU Grossman School of Medicine, New York, NY, USA

    Alexander El-Ali & Shailee Lala

  2. Division of Pediatric Hematology Oncology, Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA

    Gloria Contreras Yametti & Gabe Robbins

  3. Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    J. Christopher Davis

  4. Department of Radiology, Children’s Hospital of Pittsburgh, Pittsburgh, USA

    Andrew J. Degnan

Authors
  1. Alexander El-Ali
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  2. Gloria Contreras Yametti
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  3. Gabe Robbins
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  4. Shailee Lala
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  5. J. Christopher Davis
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  6. Andrew J. Degnan
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Editor information

Editors and Affiliations

  1. Department of Radiology, 3NW, Children's Hospital of Philadelphia, Philadelphia, PA, USA

    Summer L Kaplan

  2. Department of Radiology, 3NW, Children's Hospital of Philadelphia, Philadelphia, PA, USA

    Hansel Otero

  3. Dept Of Radiology, MCH Radiology, Miami Children's Hospital, Miami, FL, USA

    L Santiago Medina

  4. Dept of Radiology, Virginal Mason Medical Center, Seattle, WA, USA

    C. Craig Blackmore

  5. Zionsville, IN, USA

    Kimberly E Applegate

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El-Ali, A., Contreras Yametti, G., Robbins, G., Lala, S., Davis, J.C., Degnan, A.J. (2022). Langerhans Cell Histiocytosis. In: Kaplan, S.L., Otero, H., Medina, L.S., Blackmore, C.C., Applegate, K.E. (eds) Evidence-Based Imaging in Pediatrics. Evidence-Based Imaging. Springer, Cham. https://doi.org/10.1007/978-3-030-38095-3_67-1

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  • DOI: https://doi.org/10.1007/978-3-030-38095-3_67-1

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  • Print ISBN: 978-3-030-38095-3

  • Online ISBN: 978-3-030-38095-3

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