Abstract
Neuronal intermediate filaments are the most prominent cytoskeleton component of adult neurons in both central and peripheral nervous system. They include neurofilament triplet proteins, peripherin, α-internexin, nestin, and synemin. Although it was initially thought that neuronal intermediate filaments serve a primarily structural function, it has since been demonstrated that they constitute a dynamic network involved in neuronal differentiation, axon outgrowth, and regeneration. Finally, they emerged as a primary cause of some neurodegenerative diseases. Here, we focus on the properties, function, and regulation of neuronal intermediate filaments as well as their relationship to different neurodegenerative diseases.
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Perrot, R., Eyer, J. (2013). Neurofilaments: Properties, Functions, and Regulation. In: Dermietzel, R. (eds) The Cytoskeleton. Neuromethods, vol 79. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-266-7_9
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