Abstract
This is an overview of the current drug delivery systems (DDSs) starting with various routes of drug administration. Various drug formulations are then described as well as devices used for drug delivery and targeted drug delivery. There has been a considerable increase in the number of new biotechnology-based therapeutics. Most of these are proteins and peptides, and their delivery present special challenges. Cell and gene therapies are sophisticated methods of delivery of therapeutics. Nanoparticles are important for refining drug delivery. In addition to being vehicles for drug delivery, nanoparticles can be used as pharmaceuticals as well as diagnostics. Most of the advances in targeted drug delivery have occurred in therapy of cancer. Drug delivery to the brain across the blood–brain barrier presents many challenges. Refinements in drug delivery will facilitate the development of personalized medicine. The ideal DDS is defined. Commercial aspects, challenges, and future of DDSs are discussed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Jain KK (2019) Transdermal drug delivery: technologies, markets and companies. Jain PharmaBiotech Publications, Basel, pp 1–300
Donnelly RF, Garland MJ, Alkilani AZ (2014) Microneedle-iontophoresis combinations for enhanced transdermal drug delivery. Methods Mol Biol 1141:121–132
Jain KK (2019) Role of nanobiotechnology in drug delivery. In: Jain KK (ed) Drug delivery systems, 3rd edn. Humana Springer, New York, NY
Singh RM, Kumar A, Pathak K (2013) Mucoadhesive in situ nasal gelling drug delivery systems for modulated drug delivery. Expert Opin Drug Deliv 10:115–130
Abramson A, Caffarel-Salvador E, Khang M et al (2019) An ingestible self-orienting system for oral delivery of macromolecules. Science 363:611–615
Brayden DJ, Baird AW (2019) Stomaching drug delivery. N Engl J Med 380:1671–1673
Jain KK (2011) Applications of biotechnology in cardiovascular therapeutics. Springer Science, New York, NY
Jain KK (2019) Cardiovascular drug delivery: technologies, markets and companies. Jain PharmaBiotech Publications, Basel, pp 1–277
Jain KK (ed) (2010) Drug delivery to the central nervous system. Humana/Springer, New York, NY
Jain KK (2013) Applications of biotechnology in neurology. Springer, New York, NY
Jain KK (2019) Drug delivery in CNS disorders: technologies, markets and companies. Jain PharmaBiotech Publications, Basel, pp 1–384
De Andres J, Rubio-Haro R, De Andres-Serrano C et al (2019) Intrathecal drug delivery. In: Methods in molecular biology, 3rd edn. Springer, New York, NY
Majumder P (2018) Integrin-mediated delivery of drugs and nucleic acids for anti-angiogenic cancer therapy: current landscape and remaining challenges. Bioengineering (Basel) 5(4):E76
Cronin M, Akin AR, Collins SA et al (2012) High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting. PLoS One 7:e30940
Xiao H, Woods EC, Vukojicic P, Bertozzi CR (2016) Precision glycocalyx editing as a strategy for cancer immunotherapy. Proc Natl Acad Sci U S A 113:10304–10309
Jain KK (2019) Gene therapy: technologies, markets and companies. Jain PharmaBiotech Publications, Basel, pp 1–777
Farra R, Sheppard NF Jr, McCabe L et al (2012) First-in-human testing of a wirelessly controlled drug delivery microchip. Sci Transl Med 4(122):122ra21
Nguyen NT, Shaegh SA, Kashaninejad N, Phan DT (2013) Design, fabrication and characterization of drug delivery systems based on lab-on-a-chip technology. Adv Drug Deliv Rev 65:1403–1419
Castle J, Kotopoulis S, Forsberg F (2019) Microbubble drug delivery for pancreatic cancer. In: Methods in molecular biology, 3rd edn. Springer, New York, NY
Jain KK (2015) A textbook of personalized medicine, 2nd edn. Springer Science, New York, NY
Jain KK (2019) Drug delivery in cancer: technologies, markets and companies. Jain PharmaBiotech Publications, Basel, pp 1–726
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Science+Business Media, LLC, part of Springer Nature
About this protocol
Cite this protocol
Jain, K.K. (2020). An Overview of Drug Delivery Systems. In: Jain, K. (eds) Drug Delivery Systems. Methods in Molecular Biology, vol 2059. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9798-5_1
Download citation
DOI: https://doi.org/10.1007/978-1-4939-9798-5_1
Published:
Publisher Name: Humana, New York, NY
Print ISBN: 978-1-4939-9797-8
Online ISBN: 978-1-4939-9798-5
eBook Packages: Springer Protocols