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Current Status and Future Prospects of Drug Delivery Systems

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Drug Delivery System

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1141))

Abstract

This is an overview of the current drug delivery systems (DDS) starting with various routes of drug administration. Various drug formulations are then described as well as devices used for drug delivery and targeted drug delivery. There has been a considerable increase in the number of new biotechnology-based therapeutics. Most of these are proteins and peptides, and their delivery presents special challenges. Cell and gene therapies are sophisticated methods of delivery of therapeutics. Nanoparticles are considered to be important in refining drug delivery; they can be pharmaceuticals as well as diagnostics. Refinements in drug delivery will facilitate the development of personalized medicine in which targeted drug delivery will play an important role. There is discussion about the ideal DDS, commercial aspects, challenges, and future prospects.

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References

  1. Jain KK (2014) Transdermal drug delivery: technologies, markets and companies. Jain PharmaBiotech Publications, Basel, pp 1–280

    Google Scholar 

  2. Donnelly RF, Garland MJ, Alkilani AZ (2014) Microneedle-iontophoresis combinations for enhanced transdermal drug delivery, Chapter 7. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  3. Singh RM, Kumar A, Pathak K (2013) Mucoadhesive in situ nasal gelling drug delivery systems for modulated drug delivery. Expert Opin Drug Deliv 10:115–130

    Article  CAS  Google Scholar 

  4. Gizurarson S (2012) Anatomical and histological factors affecting intranasal drug and vaccine delivery. Curr Drug Deliv 9:566–582

    Article  CAS  Google Scholar 

  5. Krishnaiah YS, Khan MA (2012) Strategies of targeting oral drug delivery systems to the colon and their potential use for the treatment of colorectal cancer. Pharm Dev Technol 17:521–540

    Article  CAS  Google Scholar 

  6. Salomon JJ, Ehrhardt C (2012) Organic cation transporters in the blood-air barrier: expression and implications for pulmonary drug delivery. Ther Deliv 3(6):735–747

    Article  CAS  Google Scholar 

  7. Li HY, Zhang F (2012) Preparation of nanoparticles by spray-drying and their use for efficient pulmonary drug delivery. Methods Mol Biol 906:295–301

    CAS  Google Scholar 

  8. Beck-Broichsitter M, Dalla-Bona AC, Kissel T, Seeger W, Schmehl T (2014) Polymer nanoparticle-based controlled pulmonary drug delivery, Chapter 8. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  9. Jain KK (2011) Applications of biotechnology in cardiovascular therapeutics. Springer Science, New York

    Book  Google Scholar 

  10. Jain KK (2014) Cardiovascular drug delivery: technologies, markets and companies. Jain PharmaBiotech Publications, Basel, pp 1–268

    Google Scholar 

  11. Jain KK (ed) (2010) Drug delivery to the central nervous system. Humana, New York

    Google Scholar 

  12. Jain KK (2013) Applications of biotechnology in neurology. Springer, New York

    Book  Google Scholar 

  13. Jain KK (2014) Drug delivery in CNS disorders: technologies, markets and companies. Jain PharmaBiotech Publications, Basel, pp 1–360

    Google Scholar 

  14. Jain KK (2012) Nanobiotechnology-based strategies for crossing the blood-brain barrier. Nanomedicine 7:1225–1233

    Article  CAS  Google Scholar 

  15. Guarnieri D, Muscetti O, Netti PA (2014) A method for evaluating nanoparticle transport through the blood brain barrier in vitro, Chapter 12. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  16. De Andres J et al (2014) Intrathecal delivery of analgesics, Chapter 16. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  17. Gupta S, Batra S, Jain M (2014) Antibody labeling with radioiodine and radiometals, Chapter 9. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  18. Jain KK (2014) Gene therapy: technologies, markets and companies. Jain PharmaBiotech Publications, Basel, pp 1–665

    Google Scholar 

  19. Cummins J, Cronin M, van Pijkeren JP, Gahan C, Tangney M (2014) Bacterial systems for gene delivery to systemic tumours, Chapter 13. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  20. Cullis PR, Ramsay E (2014) Microfluidic-based manufacture of siRNA-lipid nanoparticles for therapeutic applications, Chapter 6. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  21. Gao JQ, Hu UL (2014) Stem cells as carriers for cancer gene therapy, Chapter 5. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  22. Muzykantov VR (2010) Drug delivery by red blood cells: vascular carriers designed by mother nature. Expert Opin Drug Deliv 7:403–427

    Article  CAS  Google Scholar 

  23. Boopathy AV, Davis ME (2014) Self assembling peptide-based delivery of therapeutics for myocardial infarction, Chapter 10. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  24. Farra R, Sheppard NF Jr, McCabe L et al (2012) First-in-human testing of a wirelessly controlled drug delivery microchip. Sci Transl Med 4(122):122ra21

    Article  Google Scholar 

  25. Nguyen NT, Shaegh SA, Kashaninejad N, Phan DT (2013) Design, fabrication and characterization of drug delivery systems based on lab-on-a-chip technology. Adv Drug Deliv Rev 65(11–12):1403–1419, pii: S0169-409X(13)00127-0

    Article  CAS  Google Scholar 

  26. Castle J (2014) Ultrasound-directed site-specific gene delivery, Chapter 3. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  27. Jain KK (2014) Nanobiotechnology: applications, markets and companies. Jain PharmaBiotech Publications, Basel, pp 1–774

    Google Scholar 

  28. Yamada Y, Harashima H (2014) Methodology for screening mitochondrial fusogenic envelopes for use in mitochondrial drug delivery, Chapter 2. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  29. Mishra S, De A, Mozumdar S (2014) Synthesis of a thermoresponsive polymer for drug delivery, Chapter 4. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  30. Tajmir-Riahi HA, Nafisi S, Sanyakamdhorn S et al (2014) Applications of chitosan nanoparticles in drug delivery, Chapter 11. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  31. Malhotra M, Tomaro-Duchesneau C, Saha S, Prakash S (2014) Intranasal delivery of chitosan-siRNA nanoparticle formulation to the brain, Chapter 15. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  32. Torne S, Darandale S, Vavia P et al (2013) Cyclodextrin-based nanosponges: effective nanocarrier for Tamoxifen delivery. Pharm Dev Technol 18:619–625

    Article  CAS  Google Scholar 

  33. Lesch HP, Kaikkonen MU, Pikkarainen JT, Ylä-Herttuala S (2010) Avidin-biotin technology in targeted therapy. Expert Opin Drug Deliv 7:551–564

    Article  CAS  Google Scholar 

  34. De A, Mishra S, Garg S, Mozumdar S (2014) Synthesis of a smart nanovehicle for targeting liver, Chapter 14. In: Jain KK (ed) Drug delivery system, Methods Mol Biol. Springer, New York

    Google Scholar 

  35. Jain KK (2014) Personalized medicine: scientific and commercial aspects. Jain PharmaBiotech Publications, Basel, pp 1–860

    Google Scholar 

  36. Jain KK (2009) A textbook of personalized medicine. Springer Science, New York

    Book  Google Scholar 

  37. Zhang H, Wang G, Yang H (2011) Drug delivery systems for differential release in combination therapy. Expert Opin Drug Deliv 8:171–190

    Article  CAS  Google Scholar 

  38. Jain KK (2014) Drug delivery in cancer: technologies, markets and companies. Jain PharmaBiotech Publications, Basel, pp 1–668

    Google Scholar 

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Jain, K.K. (2014). Current Status and Future Prospects of Drug Delivery Systems. In: Jain, K. (eds) Drug Delivery System. Methods in Molecular Biology, vol 1141. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0363-4_1

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  • DOI: https://doi.org/10.1007/978-1-4939-0363-4_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-0362-7

  • Online ISBN: 978-1-4939-0363-4

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