Abstract
Atomic force microscopy (AFM) enables the measurements of the elastic properties of individual cells in liquids that mimic natural conditions. The single-cell deformability, quantitatively described through the Young’s (elastic) modulus, can be used as a marker of pathological alterations, particularly those observed in cancer progression. Here, the AFM-based measurements and data analysis of mechanical properties of single cancerous cells are presented.
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Acknowledgments
This work was supported by National Science Centre (Poland) project no UMO-2014/15/B/ST4/04737. The JPK purchase has been realized under the project co-funded by the Małopolska Regional Operational Program, Measure 5.1—Krakow Metropolitan Area as an important hub of the European Research Area for 2007–2013, project No. MRPO.05.01.00-12-013/15.
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Lekka, M., Pabijan, J. (2019). Measuring Elastic Properties of Single Cancer Cells by AFM. In: Santos, N., Carvalho, F. (eds) Atomic Force Microscopy. Methods in Molecular Biology, vol 1886. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8894-5_18
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DOI: https://doi.org/10.1007/978-1-4939-8894-5_18
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