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Perinatal Psychoneuroimmunology: Protocols for the Study of Prenatal Stress and Its Effects on Fetal and Postnatal Brain Development

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Psychoneuroimmunology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1781))

Abstract

Prenatal stress (PS) impacts early behavioral, neuroimmune, and cognitive development. Pregnant rat models have been very valuable in examining the mechanisms of such fetal programming. A newer pregnant sheep model of maternal stress offers the unique advantages of chronic in utero monitoring and manipulation. This chapter presents the techniques used to model single and multigenerational stress exposures and their pleiotropic effects on the offspring.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA

    Martin G. Frasch

  2. Departamento de Biología, Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Bioquímica y Farmacia (DBByF), Universidad Nacional del Sur (UNS), Bahía Blanca, Argentina

    Carlos J. Baier

  3. Facultad de Medicina, Instituto de Biología Celular y Neurociencia “Prof. Eduardo De Robertis”, Universidad de Buenos Aires, Buenos Aires, Argentina

    Marta C. Antonelli

  4. Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada

    Gerlinde A. S. Metz

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  1. Martin G. Frasch
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  2. Carlos J. Baier
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  3. Marta C. Antonelli
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  4. Gerlinde A. S. Metz
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Corresponding author

Correspondence to Martin G. Frasch .

Editor information

Editors and Affiliations

  1. University of Maryland University College, Adelphi, MD, PharmTao, Santa Clara, California, USA

    Qing Yan

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Frasch, M.G., Baier, C.J., Antonelli, M.C., Metz, G.A.S. (2018). Perinatal Psychoneuroimmunology: Protocols for the Study of Prenatal Stress and Its Effects on Fetal and Postnatal Brain Development. In: Yan, Q. (eds) Psychoneuroimmunology. Methods in Molecular Biology, vol 1781. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7828-1_19

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  • DOI: https://doi.org/10.1007/978-1-4939-7828-1_19

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7827-4

  • Online ISBN: 978-1-4939-7828-1

  • eBook Packages: Springer Protocols

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