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Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG® KO Mice

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Hepatocyte Transplantation

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1506))

Abstract

Mice with humanized chimeric liver are promising in vivo tools to evaluate the efficacy of novel compounds or vaccine induced antibodies directed against pathogens that infect the human liver. In addition they can be used to study the human-type metabolism of medicinal compounds and hepatotoxicity.

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Author information

Authors and Affiliations

  1. Departments of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, MRB2, De Pintelaan 185, Ghent, 9000, Belgium

    Lander Foquet, Lieven Verhoye, Geert Leroux-Roels & Philip Meuleman

  2. Yecuris Corp, Tualatin, OR, USA

    Elizabeth M. Wilson, Markus Grompe & John Bial

  3. Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR, USA

    Markus Grompe

Authors
  1. Lander Foquet
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  2. Elizabeth M. Wilson
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  3. Lieven Verhoye
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  4. Markus Grompe
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  5. Geert Leroux-Roels
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  6. John Bial
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  7. Philip Meuleman
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Corresponding author

Correspondence to Philip Meuleman .

Editor information

Editors and Affiliations

  1. Department of Surgery, University of Leipzig, Leipzig, Germany

    Peggy Stock

  2. Department of Surgery, University of Leipzig, Leipzig, Germany

    Bruno Christ

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Foquet, L. et al. (2017). Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG® KO Mice. In: Stock, P., Christ, B. (eds) Hepatocyte Transplantation. Methods in Molecular Biology, vol 1506. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6506-9_8

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  • DOI: https://doi.org/10.1007/978-1-4939-6506-9_8

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6504-5

  • Online ISBN: 978-1-4939-6506-9

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