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In Vitro Approaches to Predictive Biokinetics

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In Vitro Toxicology Systems

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

In the new paradigm of toxicology, risk assessment of chemicals needs to be based on a proper interpretation of the compound’s mechanism of action. When these assessments are based on in silico and in vitro prediction models, the quantification of the toxicodynamic as well as biokinetic parameters becomes essential. For this purpose, well-designed in vitro toxicity tests need to be used that are relevant for the risk situation to be evaluated. Furthermore, in vitro data may be applied in constructing physiologically based biokinetic models. Parameters that can be derived either from in vitro data or from in silico predictions include estimates of absorption, partitioning, metabolism, and excretion. The combination of in vitro toxicodynamics and biokinetic modelling in integrated testing strategies has proven to be a useful concept that can be applied in the process of human risk assessments.

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Authors and Affiliations

  1. Division of Toxicology, Institute for Risk Assessment Sciences, Utrecht University, 80177, 3508 TD, Utrecht, The Netherlands

    Bas J. Blaauboer

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  1. Bas J. Blaauboer
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Correspondence to Bas J. Blaauboer .

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Editors and Affiliations

  1. European Commission Joint Research Centre, Ispra, Varese, Italy

    Anna Bal-Price

  2. Innsbruck Medical University, Innsbruck, Austria

    Paul Jennings

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Blaauboer, B.J. (2014). In Vitro Approaches to Predictive Biokinetics. In: Bal-Price, A., Jennings, P. (eds) In Vitro Toxicology Systems. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0521-8_23

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  • DOI: https://doi.org/10.1007/978-1-4939-0521-8_23

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-0520-1

  • Online ISBN: 978-1-4939-0521-8

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