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Inflammasome-Independent Roles of NLR and ALR Family Members

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NLR Proteins

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2696))

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Abstract

Pattern recognition receptors, including members of the NLR and ALR families, are essential for recognition of both pathogen- and host-derived danger signals. Several members of these families, including NLRP1, NLRP3, NLRC4, and AIM2, are capable of forming multiprotein complexes, called inflammasomes, that result in the activation of pro-inflammatory caspase-1. However, in addition to the formation of inflammasomes, a number of these family members exert inflammasome-independent functions. Here, we will discuss inflammasome-independent functions of NLRC4, NLRP12, and AIM2 and examine their roles in regulating innate and adaptive immune processes.

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Acknowledgments

NIH grant R21 AI156919 (F.S.S.) supported this work.

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Authors and Affiliations

  1. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Suman Gupta, Suzanne L. Cassel & Fayyaz S. Sutterwala

  2. Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Suman Gupta, Suzanne L. Cassel & Fayyaz S. Sutterwala

Authors
  1. Suman Gupta
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  2. Suzanne L. Cassel
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  3. Fayyaz S. Sutterwala
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Corresponding author

Correspondence to Fayyaz S. Sutterwala .

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Editors and Affiliations

  1. Molecular Inflammation Group, Biomedical Research Institute of Murcia, El Palmar, Spain

    Pablo Pelegrín

  2. Department of Morphology, University of Ferrara, Ferrara, Ferrara, Italy

    Francesco Di Virgilio

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Gupta, S., Cassel, S.L., Sutterwala, F.S. (2023). Inflammasome-Independent Roles of NLR and ALR Family Members. In: Pelegrín, P., Di Virgilio, F. (eds) NLR Proteins. Methods in Molecular Biology, vol 2696. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3350-2_2

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  • DOI: https://doi.org/10.1007/978-1-0716-3350-2_2

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3349-6

  • Online ISBN: 978-1-0716-3350-2

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