Abstract
Obesity is associated with chronic, low-grade systemic inflammation and leads to changes in the immune microenvironment of various tissues. As a result, obesity is associated with increased risk of cancer and a worse prognosis in patients. Given the prevalence of obesity worldwide, understanding the fundamental biology governing the relationship between obesity and cancer is critical. In this chapter, we describe preclinical models of obesity that can be combined with standard tumor models and techniques to study the tumor-immune microenvironment. We also discuss important considerations when planning experiments involving these models.
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S.P. and D.Q. designed the protocols and wrote the manuscript. S.P. optimized the protocols, performed the experiments, and generated the figures.
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Petrecca, S., Quail, D.F. (2023). Mouse Models of Obesity to Study the Tumor-Immune Microenvironment. In: Ursini-Siegel, J. (eds) The Tumor Microenvironment. Methods in Molecular Biology, vol 2614. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2914-7_9
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DOI: https://doi.org/10.1007/978-1-0716-2914-7_9
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